Save your search and get notified when new inventory arrives.
Contact seller
Customize your budget
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
About your privacy: Cars.com is asking for your ZIP and credit rating because it helps us to make an educated guess at your sales tax and loan interest. These two factors can greatly change your monthly payment.
Used
2021 Mercedes-Benz S-Class
for sale
near
Lighthouse Point, FL
- Down Payment
- $0
- Net trade-in value
- $0
- Months
- 72
- APR
- 7.0%
- Sales tax
- 0.0%
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Milson was great to work with, he made sure I was 100%
Milson was great to work with, he made sure I was 100% satisfied and walked me through the process of buying and shipping the car.
An Absolute Dream
I have owned 6 S Class (SonderKlas) cars in my life and each and every single one has been problem free and a pure joy to own, drive, and admire. The 2021 S580 however.. Well this car is truly something special and not an incremental upgrade! This thing is crazy






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Excellent service from the salesman Hashen, very
Excellent service from the salesman Hashen, very knowledgeable, respectful and very helpful. Very good financial service provided by the expert team. Overall it was great experience!!!
Luxury
Luxury at its best, you can’t get better than that with this price range. S 580 is the way to go, the 8 cylinders are so smooth yet so sporty. This car can be Rolls Royce luxury and lamborghini urus if it wants






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
My service rep Evelyn precise, efficient, and pleasant to
My service rep Evelyn precise, efficient, and pleasant to work with. The car was returned washed and cleaned. Waiting for the car was enjoyable and did not take too long.






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
They were amazing.
They were amazing. They gave me hope again and finally got me a brand new ride which I lost hope for. But with much patience they worked hard to get the job done! I am so appreciative for them.






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
i have bought 14 mercedes for my family with sam e at
i have bought 14 mercedes for my family with sam e at mercedes of ft lauderdale he is professional and honest he made todays transaction feb 22 easy and rewarding ty sam






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Top top experience.
Top top experience. Check out Marcos. Held the car for me until I flew in. Personally picked me up from the airport and brought me to the dealership.






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Great company that helped me with all my questions.
Great company that helped me with all my questions. Would definitly use them again as they were very prompt to respond.






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
I look for long time and found great car for great
I look for long time and found great car for great price ! Will be back in future !






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Great cars! Awesome people!
I found these guys online and decided to pay them a visit. I was in the market for a Bentley GT and they had a handful. Long story short, Danny was a pleasure to work with, and they worked out a great deal. I ended up going home in my new car. If you're in the market for a clean luxury or exotic car, give these guys a shot.

Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Mi expediente fue excelente con el seller y el vendedor q
Mi expediente fue excelente con el seller y el vendedor q nos atendió es Rodolfo un buena atención
There are 20 matching cars close to your year range.






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Mercedes-Benz Certified
2023 Mercedes-Benz S-Class 4MATIC
Vehicle information
Features






Used
2023 Mercedes-Benz S-Class 4MATIC
Vehicle information
Features






Used
2023 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2019 Mercedes-Benz S-Class S 450 4MATIC
Vehicle information
Features






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2019 Mercedes-Benz S-Class S 560
Vehicle information
Features






Used
2019 Mercedes-Benz S-Class
Vehicle information
Features






Used
2022 Mercedes-Benz S-Class 4MATIC
Vehicle information
Features






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2020 Mercedes-Benz S-Class S 560
Vehicle information
Features






Used
2019 Mercedes-Benz S-Class 4MATIC
Vehicle information
Features






Used
2023 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Mercedes-Benz Certified
2022 Mercedes-Benz S-Class 4MATIC
Vehicle information
Features






Used
2023 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2023 Mercedes-Benz S-Class S 500 4MATIC
Vehicle information
Features
-
Prev - 1
-
Next
Mercedes-Benz S-Class prices by year
Model year | Prices from | Deals |
---|---|---|
2025 Mercedes-Benz S-Class | $120,977 | 1 Good deal |
2023 Mercedes-Benz S-Class | $51,999 | 5 Great deals |
2022 Mercedes-Benz S-Class | $48,888 | 7 Great deals |
2019 Mercedes-Benz S-Class | $29,917 | 4 Good deals |
About the 2021 Mercedes-Benz S-Class
S 500 4MATIC shown (base trim).
- Seating
- 5
- Door count
- 4
- Drivetrain
- All-wheel Drive
- Combined MPG
- 24
- Transmission
- 9-Speed A/T
- Engine
- 429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)

How much does the 2021 Mercedes-Benz S-Class cost?
The 2021 Mercedes-Benz S-Class price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 S-Class is $73,847, with pricing starting at $48,549.
What is the MPG of the 2021 Mercedes-Benz S-Class?
The 2021 Mercedes-Benz S-Class offers up to 20 MPG in city driving and 29 MPG on the highway for a combined rating of 24 MPG.
These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.
What are some similar vehicles and competitors of the 2021 Mercedes-Benz S-Class?
The 2021 Mercedes-Benz S-Class compares to and/or competes against the following vehicles:
Is the 2021 Mercedes-Benz S-Class reliable?
The 2021 Mercedes-Benz S-Class has an average reliability rating of 5 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 S-Class owners.
Is the 2021 Mercedes-Benz S-Class a good sedan?
Below are the Cars.com consumer ratings for the 2021 Mercedes-Benz S-Class.
- Comfort 5.0
- Interior 5.0
- Performance 5.0
- Value 4.7
- Exterior 5.0
- Reliability 5.0
100% of drivers recommend this car
- Comfort 5.0
- Interior 5.0
- Performance 5.0
- Value 4.7
- Exterior 5.0
- Reliability 5.0
S 500 (1 style)
Style |
---|
S 500 4MATIC Sedan |
Inventory price |
Starting at $109,800 |
Combined MPG |
24 |
Engine |
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) |
S 560 (2 styles)
Style | |
---|---|
S 560 Cabriolet | S 560 4MATIC Coupe |
Inventory price | |
Starting at $140,000 | Starting at $131,400 |
Combined MPG | |
20 | 20 |
Engine | |
463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel) | 463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel) |
S 580 (1 style)
Style |
---|
S 580 4MATIC Sedan |
Inventory price |
Starting at $116,300 |
Combined MPG |
20 |
Engine |
496.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline/Mild Electric Hybrid) |
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
Research the 2021 Mercedes-Benz S-Class
Compare the 2021 Mercedes-Benz S-Class
- ${price_badge()}
- ${ami_badge()}
- ${battery_badge()}${ev_report_link()}
- ${hot_car_badge()}
- ${award_badge()}
- ${cpo_badge()}
${price_badge_description}
${ami_badge_description}
The EV Battery Rating is based on this vehicle's current expected range relative to the vehicles expected range when new. ${battery_badge_text}
Certified cars are manufacturer warrantied and typically go through a rigorous multi-point inspection.
This car is likely to sell soon based on the price, features, and condition.
${award_blurb}
${award_two_blurb}