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*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
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Used
2022 Mercedes-Benz S-Class
for sale
near
Cleveland, OH
- Down Payment
- $0
- Net trade-in value
- $0
- Months
- 72
- APR
- 7.0%
- Sales tax
- 0.0%
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Thank you to Zach and the entire team at Perfect Auto
Thank you to Zach and the entire team at Perfect Auto Collection for making my car buying process smooth and simple. From the very start of my car search, Perfect Auto Collection has by far THE best pictures and website you will find anywhere in the automotive world. When I decided to purchase my vehicle, every question I had was answered prompt and professionally. From there, the team at Perfect Auto Collection scheduled the shipment of my car. When the car first rolled off the truck I was taken back just how nice it really was. I purchased the car sight unseen and have never been to the dealership in person; there is no need to because the team at Perfect Auto Collection takes care of all the details for you. I have purchased cars at similar high-end dealerships, but the overall experience at Perfect Auto Collection is unmatched. I will definitely be back in the future. Thank you!
MBZ S-class always 5 ***** vehicle.
MBZ S-class always 5 ***** vehicle. The most luxurious , comfortable, car I ever drove . I highly recommend it . My old Mercedes S-class has 200,000 miles and not a single problem.






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
A Wonderful Overall Experience
I just picked up my S580 Lux-Line in Emerald Green over Sienna Brown, and I am absolutely thrilled with the purchase. I have owned five S-Class models since 2010, including this new one, and I can say this is the best iteration yet from an overall perspective. While I still think the W222 was the best-looking (especially my 2019 S560 with the refreshed look and AMG pack), this new one does not disappoint at all. The Emerald Green is stunning in the sunlight, my favorite color yet. And the interior is on another level from a luxury and tech standpoint. I loved the interiors of all the S-Class models I've owned, but this current one is my favorite. The seats are super supportive, and the vast amount of tech is amazing. The new infotainment screen takes time to learn and get used to, but I feel the "Hey, Mercedes" function makes doing small things like putting in a Navigation request easier than going through the main screen. From a driving perspective, the ride is the best yet, just like gliding on a cloud. I've been lucky to have driven Bentley's and Rolls-Royce's in my lifetime, and this ride is as close as I've seen the S-Class come to being even with those vehicles on this front. And, the V8 is plenty punchy when needed, so it can be a fun vehicle to take on windy roads if you so desire. Overall, a wonderful vehicle and a bargain when you compare it to the other super-luxury vehicles on sale. I'm looking forward to the next few years of owning such an awesome car.






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Mike was my salesperson and Jared was my finance manager
Mike was my salesperson and Jared was my finance manager that were incredibly helpful. They had to deal with a challenging situation with their system upgrades, but navigated the situation perfectly and got me into my new car within 24 hours. I really liked working with them both and highly recommend the dealership!






Used
2022 Mercedes-Benz S-Class 4MATIC
Vehicle information
Features
Reviews
I had a wonderful car-buying experience at North Coast
I had a wonderful car-buying experience at North Coast Mitsubishi West Cleveland. Dominic, my salesman, was extremely helpful, patient, and professional throughout the whole process. He took the time to explain everything clearly, answered all of my questions, and made me feel confident in my purchase. Dominic went above and beyond to make sure I got the right car at the right price. I really appreciate his honesty and knowledge — he made the entire experience smooth and stress-free. Highly recommend asking for Dominic if you’re shopping here!






Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
I called the dealership as I was very interested in an
I called the dealership as I was very interested in an automobile that they had I spoke with Alan he was very nice I sent him photos and necessary information on my vehicle that I want to trade I reviewed their offer and it was very fair. After more consideration we decided to keep the car we have but when we do buy a high end car I will keep this dealership in mind.
Used
2022 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Barry was amazing from start to finish.
Barry was amazing from start to finish. Exceptional customer service. Thank you so much X
There are 4 matching cars close to your year range.






Used
2020 Mercedes-Benz S-Class S 560
Vehicle information
Features






Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features






Used
2023 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features

Used
2023 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
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About the 2022 Mercedes-Benz S-Class
S 500 4MATIC shown (base trim).
- Seating
- 5
- Door count
- 4
- Drivetrain
- All-wheel Drive
- Combined MPG
- 24
- Transmission
- 9-Speed A/T
- Engine
- 429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)

How much does the 2022 Mercedes-Benz S-Class cost?
The 2022 Mercedes-Benz S-Class price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 S-Class is $71,226, with pricing starting at $48,426.
What is the MPG of the 2022 Mercedes-Benz S-Class?
The 2022 Mercedes-Benz S-Class offers up to 21 MPG in city driving and 30 MPG on the highway for a combined rating of 24 MPG.
These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.
What are some similar vehicles and competitors of the 2022 Mercedes-Benz S-Class?
The 2022 Mercedes-Benz S-Class compares to and/or competes against the following vehicles:
Is the 2022 Mercedes-Benz S-Class reliable?
The 2022 Mercedes-Benz S-Class has an average reliability rating of 3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 S-Class owners.
Is the 2022 Mercedes-Benz S-Class a good sedan?
Below are the Cars.com consumer ratings for the 2022 Mercedes-Benz S-Class.
- Comfort 5.0
- Interior 4.0
- Performance 4.5
- Value 3.5
- Exterior 4.2
- Reliability 3.0
50% of drivers recommend this car
- Comfort 5.0
- Interior 4.0
- Performance 4.5
- Value 3.5
- Exterior 4.2
- Reliability 3.0
S 500 (1 style)
Style |
---|
S 500 4MATIC Sedan |
Inventory price |
Starting at $111,100 |
Combined MPG |
24 |
Engine |
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) |
S 580 (1 style)
Style |
---|
S 580 4MATIC Sedan |
Inventory price |
Starting at $117,700 |
Combined MPG |
19 |
Engine |
496.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline/Mild Electric Hybrid) |
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
Research the 2022 Mercedes-Benz S-Class
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This vehicle is certified pre-owned, backed by a manufacturer warranty, and typically undergoes a rigorous multi-point inspection to ensure quality and reliability.
This vehicle is currently in high demand given its competitive price, desirable features, and overall condition, and may have a higher chance of selling quickly.