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Used 2022 Lexus IS 350 sedans for sale near me

Filters 5 Year Model Price & payment Make Mileage Body style All filters
1 match 30 miles from 43272
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Est. $400 /mo*
Down Payment
$0
Net trade-in value
$0
Months
72
APR
7.0%
Sales tax
0.0%

*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.

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2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base View all 42 photos

Used

2022 Lexus IS 350 Base

42,451 mi.
$43,570
Est. $802/mo*
Twins Auto of Dublin
(92 reviews)
Dublin, OH (12 mi.)
Call Check availability Check availability

Vehicle information

Ext. color: Silver
Int. color: Red
Drivetrain: All-wheel Drive
MPG: 19-26
Fuel type: Gasoline
Transmission: Automatic
Engine: 3.5L V-6 port/direct injection, DOHC, VVT-i variable valve contr
Stock #: D4980L
VIN: JTHGZ1E21N5024238

Features

Convenience: Adaptive Cruise Control, Cooled Seats, Heated Seats, Heated Steering Wheel, Keyless Entry, Keyless Start, Navigation System, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, CD Player, HomeLink, USB Port, WiFi Hotspot
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Automatic Emergency Braking, Backup Camera, Blind Spot Monitor, Brake Assist, LED Headlights, Lane Departure Warning, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Leather Seats

Reviews

Twins Auto of Dublin review

My car sales person, Leena Help me find the perfect car

November 8, 2025
By Monte from Dublin Ohio

My car sales person, Leena Help me find the perfect car and I couldn’t be happier with the service that she provided to me will be coming back for more cars in the future!

2022 Lexus IS 350 Base review

Eddie V.

April 26, 2023
By Eddie V. from Los Angeles, CA
Owns this car

Fun to drive. Handles very well. The only draw back I have is the use of premium gas especially at these high gas prices. Overall good.

There are additional matching cars outside your search area.

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2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base View all 35 photos

Used

2022 Lexus IS 350 Base

27,564 mi.
$40,394 $405 price drop
Est. $744/mo*
Victory Toyota Charleston
Charleston, WV (132 mi.)

Vehicle information

Ext. color: Silver
Int. color: Black W/Black
Drivetrain: All-wheel Drive
MPG: 19-26
Fuel type: Gasoline
Transmission: Automatic
Engine: 3.5L V-6 port/direct injection, DOHC, VVT-i variable valve contr
Stock #: 89E12025
VIN: JTHGZ1E2XN5026277

Features

Convenience: Adaptive Cruise Control, Cooled Seats, Heated Seats, Heated Steering Wheel, Keyless Entry, Keyless Start, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, CD Player, HomeLink, USB Port, WiFi Hotspot
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Automatic Emergency Braking, Backup Camera, Blind Spot Monitor, Brake Assist, LED Headlights, Lane Departure Warning, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Leather Seats
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base View all 11 photos

Used

2022 Lexus IS 350 Base

39,048 mi.
$39,176
Est. $721/mo*
Alderman Automotive
Fishers, IN (159 mi.)

Vehicle information

Ext. color: Ultra White
Int. color: Circuit Red
Drivetrain: All-wheel Drive
MPG: 19-26
Fuel type: Gasoline
Transmission: Automatic
Engine: 3.5L V-6 port/direct injection, DOHC, VVT-i variable valve contr
Stock #: K1733A
VIN: JTHGZ1E26N5023831

Features

Convenience: Adaptive Cruise Control, Cooled Seats, Heated Seats, Heated Steering Wheel, Keyless Entry, Keyless Start, Navigation System, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, CD Player, HomeLink, Premium Sound System, USB Port, WiFi Hotspot
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Automatic Emergency Braking, Backup Camera, Blind Spot Monitor, Brake Assist, LED Headlights, Lane Departure Warning, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Leather Seats
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport View all 39 photos

Used

2022 Lexus IS 350 F Sport

22,571 mi.
$40,611 $262 price drop
Est. $748/mo*
Courtesy Cadillac
Louisville, KY (184 mi.)

Vehicle information

Ext. color: Ultra White
Int. color: Black
Drivetrain: All-wheel Drive
MPG: 19-26
Fuel type: Gasoline
Transmission: 6-Speed Automatic
Engine: 3.5L V6 24V PDI DOHC
Stock #: P023878
VIN: JTHGZ1E2XN5023878

Features

Convenience: Adaptive Cruise Control, Heated Seats, Heated Steering Wheel, Keyless Entry, Remote Start
Entertainment: Apple CarPlay®, Bluetooth®, CD Player, HomeLink, Premium Sound System, Satellite Radio
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Backup Camera, Brake Assist, Rain Sensing Wipers, Stability Control
Seating: Leather Seats
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport
2022 Lexus IS 350 F Sport View all 25 photos

Used

2022 Lexus IS 350 F Sport

22,610 mi.
$41,330
Est. $761/mo*
BMW of Cincinnati North
Cincinnati, OH (91 mi.)

Vehicle information

Ext. color: Ultra White
Int. color: Black
Drivetrain: All-wheel Drive
MPG: 19-26
Fuel type: Gasoline
Transmission: 6-Speed Automatic
Engine: 3.5L V6 24V PDI DOHC
Stock #: B77620
VIN: JTHGZ1E29N5026478

Features

Convenience: Adaptive Cruise Control, Heated Seats, Heated Steering Wheel, Keyless Entry, Keyless Start, Navigation System, Remote Start
Entertainment: Bluetooth®, CD Player, HomeLink, Premium Sound System, Satellite Radio, WiFi Hotspot
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Brake Assist, LED Headlights, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Leather Seats
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base
2022 Lexus IS 350 Base

Used

2022 Lexus IS 350 Base

21,474 mi.
$41,788
Est. $769/mo*
Don Franklin Lexington Buick GMC
Lexington, KY (157 mi.)

Vehicle information

Ext. color: Caviar
Int. color: Black w/Black
Drivetrain: All-wheel Drive
MPG: 19-26
Fuel type: Gasoline
Transmission: Automatic
Engine: 3.5L V-6 port/direct injection, DOHC, VVT-i variable valve contr
Stock #: N5027089
VIN: JTHGZ1E23N5027089

Features

Convenience: Adaptive Cruise Control, Cooled Seats, Heated Seats, Heated Steering Wheel, Keyless Entry, Keyless Start, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, CD Player, HomeLink, USB Port, WiFi Hotspot
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Automatic Emergency Braking, Backup Camera, Blind Spot Monitor, Brake Assist, LED Headlights, Lane Departure Warning, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Leather Seats, Memory Seat
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Lexus IS 350 prices by year

Model year Average price Deals
2025 Lexus IS 350 $50,881 20 Great deals
2024 Lexus IS 350 $43,448 9 Great deals
2023 Lexus IS 350 $41,700 105 Good deals
2021 Lexus IS 350 $36,345 9 Good deals
2020 Lexus IS 350 $30,626 12 Good deals

About the 2022 Lexus IS 350

Basics

F Sport shown (base trim).

Seating
5
Door count
4
Drivetrain
Rear-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
311.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus IS 350
FAQs

How much does the 2022 Lexus IS 350 cost?

The 2022 Lexus IS 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 IS 350 is $38,686, with pricing starting at $29,000.

What is the MPG of the 2022 Lexus IS 350?

The 2022 Lexus IS 350 offers up to 20 MPG in city driving and 28 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2022 Lexus IS 350 reliable?

The 2022 Lexus IS 350 has an average reliability rating of 5 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 IS 350 owners.

Is the 2022 Lexus IS 350 a good sedan?

Below are the Cars.com consumer ratings for the 2022 Lexus IS 350.

(1 review)
Rating breakdown (out of 5):
  • Comfort 4.0
  • Interior 4.0
  • Performance 4.0
  • Value 3.0
  • Exterior 4.0
  • Reliability 5.0
Ratings (1 review)

100% of drivers recommend this car

Rating breakdown (out of 5):
  • Comfort 4.0
  • Interior 4.0
  • Performance 4.0
  • Value 3.0
  • Exterior 4.0
  • Reliability 5.0
Trims

IS 350 F SPORT (2 styles)

Style
IS 350 F SPORT RWD IS 350 F SPORT AWD
Inventory price
Starting at $43,550 Starting at $45,550
Combined MPG
23 22
Engine
311.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 311.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.

**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.

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IS 350 trims
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‡Monthly budget search results are estimated based on a 72-month loan term with $0 down payment, $0 trade-in value, 0.0% sales tax and 7.0% APR. Inputs can be personalized using the calculator.
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