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Used 2021 Mercedes-Benz S-Class for sale near Saint Louis, MO

Filters 4 Year Model Price & payment Make Mileage All filters
1 match 30 miles from 63156
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Est. $400 /mo*
Down Payment
$0
Net trade-in value
$0
Months
72
APR
7.0%
Sales tax
0.0%

*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.

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2021 Mercedes-Benz S-Class S 580 4MATIC
2021 Mercedes-Benz S-Class S 580 4MATIC
2021 Mercedes-Benz S-Class S 580 4MATIC
2021 Mercedes-Benz S-Class S 580 4MATIC
2021 Mercedes-Benz S-Class S 580 4MATIC
2021 Mercedes-Benz S-Class S 580 4MATIC View all 21 photos

Used

2021 Mercedes-Benz S-Class S 580 4MATIC

30,690 mi.
$57,994 $500 price drop
Est. $1,084/mo*
Genesis of St. Charles
(89 reviews)
St. Peters, MO (23 mi.)
Call Check availability Check availability

Vehicle information

Ext. color: Obsidian Black Metallic
Int. color: Black
Drivetrain: All-wheel Drive
MPG: 17-25
Fuel type: Gasoline
Transmission: 9-Speed Automatic
Engine: 4.0L V8 32V GDI DOHC Twin Turbo
Stock #: G1528-1
VIN: W1K6G7GB6MA033161

Features

Convenience: Adaptive Cruise Control, Heated Seats, Keyless Entry, Navigation System, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, HomeLink, Premium Sound System, Satellite Radio
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Brake Assist, Rain Sensing Wipers, Stability Control
Seating: Leather Seats, Memory Seat

Reviews

Genesis of St. Charles review

Working with Milan Venezia at Genesis of Saint Charles

July 10, 2025
By Shaun Swearengen from St Charles Mo

Working with Milan Venezia at Genesis of Saint Charles was honestly one of the easiest car-buying experiences I’ve ever had. He made the whole process smooth and stress-free. It went so well that when my fiancé said she was thinking about getting a new car less than a week after I purchased mine I didn’t think twice—I called Milan right away. From start to finish, he was super helpful, honest, and even funny at times, which made the experience that much better. Even the finance guy was cool and easy to work with. And I thought it was pretty cool that a concierge walked me through all the car’s features before I pulled off the lot—great touch. If you’re looking for a dealership that’s honest, has great service, and a clean, welcoming vibe, definitely check out Genesis of Saint Charles and ask for Milan Venezia. You won’t regret it.

2021 Mercedes-Benz S-Class S 580 4MATIC review

Franklin is great.

November 13, 2025
By Curtis from Fayetteville
Owns this car

Franklin is great. Thank you for your support help and patience with me. Love the car. At rides great. The paperwork and process was fast

There are 2 matching cars close to your year range.

2023 Mercedes-Benz S-Class
2023 Mercedes-Benz S-Class
2023 Mercedes-Benz S-Class

Mercedes-Benz Certified

2023 Mercedes-Benz S-Class

35,252 mi.
$68,916
Est. $1,289/mo*
Mercedes-Benz of St Louis
St. Louis, MO (3 mi.)
Call

Vehicle information

Ext. color: MANUFAKTUR Diamond White
Int. color: Macchiato/ Magma Grey Exclusive Nappa Leather
Drivetrain: All-wheel Drive
Fuel type: Hybrid
Stock #: PC871
VIN: W1K6G6DB6PA188988
2023 Mercedes-Benz S-Class S 580 4MATIC
2023 Mercedes-Benz S-Class S 580 4MATIC
2023 Mercedes-Benz S-Class S 580 4MATIC
2023 Mercedes-Benz S-Class S 580 4MATIC
2023 Mercedes-Benz S-Class S 580 4MATIC
2023 Mercedes-Benz S-Class S 580 4MATIC View all 38 photos

Used

2023 Mercedes-Benz S-Class S 580 4MATIC

8,389 mi.
$90,995
Est. $1,702/mo*
Holman Motorcars St. Louis
Chesterfield, MO (20 mi.)
Call Check availability Check availability

Vehicle information

Ext. color: Cirrus Silver Metallic
Int. color: Macchiato Beige
Drivetrain: All-wheel Drive
MPG: 16-25
Fuel type: Gasoline
Transmission: 9-Speed Automatic
Engine: 4.0L V8 32V GDI DOHC Twin Turbo
Stock #: PA167962
VIN: W1K6G7GB2PA167962

Features

Convenience: Adaptive Cruise Control, Heated Seats, Keyless Entry, Navigation System, Remote Start
Entertainment: Apple CarPlay®, Bluetooth®, HomeLink, Premium Sound System, Satellite Radio
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Backup Camera, Brake Assist, Rain Sensing Wipers, Stability Control
Seating: Leather Seats, Memory Seat
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About the 2021 Mercedes-Benz S-Class

Basics

S 500 4MATIC shown (base trim).

Seating
5
Door count
4
Drivetrain
All-wheel Drive
Combined MPG
24
Transmission
9-Speed A/T
Engine
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2021 Mercedes-Benz S-Class
FAQs

How much does the 2021 Mercedes-Benz S-Class cost?

The 2021 Mercedes-Benz S-Class price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 S-Class is $59,704, with pricing starting at $45,995.

What is the MPG of the 2021 Mercedes-Benz S-Class?

The 2021 Mercedes-Benz S-Class offers up to 20 MPG in city driving and 29 MPG on the highway for a combined rating of 24 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz S-Class?

The 2021 Mercedes-Benz S-Class compares to and/or competes against the following vehicles:

Is the 2021 Mercedes-Benz S-Class reliable?

The 2021 Mercedes-Benz S-Class has an average reliability rating of 5 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 S-Class owners.

Is the 2021 Mercedes-Benz S-Class a good sedan?

Below are the Cars.com consumer ratings for the 2021 Mercedes-Benz S-Class.

(4 reviews)
Rating breakdown (out of 5):
  • Comfort 5.0
  • Interior 5.0
  • Performance 5.0
  • Value 4.8
  • Exterior 5.0
  • Reliability 5.0
Ratings (4 reviews)

100% of drivers recommend this car

Rating breakdown (out of 5):
  • Comfort 5.0
  • Interior 5.0
  • Performance 5.0
  • Value 4.8
  • Exterior 5.0
  • Reliability 5.0
Trims

S 500 (1 style)

Style
S 500 4MATIC Sedan
Inventory price
Starting at $109,800
Combined MPG
24
Engine
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)

S 560 (2 styles)

Style
S 560 Cabriolet S 560 4MATIC Coupe
Inventory price
Starting at $140,000 Starting at $131,400
Combined MPG
20 20
Engine
463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel) 463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel)

S 580 (1 style)

Style
S 580 4MATIC Sedan
Inventory price
Starting at $116,300
Combined MPG
20
Engine
496.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline/Mild Electric Hybrid)

*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.

**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.

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Basics
Mercedes-Benz models
S-Class trims
Price & payment Full Price Monthly
‡Monthly budget search results are estimated based on a 72-month loan term with $0 down payment, $0 trade-in value, 0.0% sales tax and 7.0% APR. Inputs can be personalized using the calculator.
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