The short answer to the question above, as our colleagues at Cars.com note, is likely no, mainly because there isn't a midsize, full-size or heavy-duty pickup truck owner's manual that says so. But that doesn’t mean there aren’t some good reasons to switch.
One of the easiest ways to be nice to your truck is to give it "the good stuff," meaning higher-quality synthetic engine oil. Synthetic oils offer better performance at both higher and lower engine temperatures than conventional oils, but using it will cost quite a bit more. For older engines, synthetics can reduce sludge buildup, and it may even result in better fuel economy. But make sure you do your research; don't simply rely on your neighbor's advice or any of the popular myths about oil.
So if you're planning on giving your truck a treat and the circumstances are right, using synthetic oil may be the right thing to do.