Save your search and get notified when new inventory arrives.
Contact seller
Customize your budget
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
About your privacy: Cars.com is asking for your ZIP and credit rating because it helps us to make an educated guess at your sales tax and loan interest. These two factors can greatly change your monthly payment.
Used
2022 Lexus RX 350
for sale
near
Midlothian, IL
- Down Payment
- $0
- Net trade-in value
- $0
- Months
- 72
- APR
- 7.0%
- Sales tax
- 0.0%
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
I had a great experience at Toyota.
I had a great experience at Toyota. Everyone was understanding and professional. I would recommend this location to anyone who's looking for car assistance.
Love this car.
Love this car. Sitting in the driver’s seat is so comfortable. Silky smooth engine. Rides so nice and quiet. We have looked for this color Grecian water for a long time. Wanted no newer than a 2022 because we didn’t want the 4 cylinder. The 3.5 V6 runs so smooth. Would definitely recommend the purchase of this SUV.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
I just love how my advisor Jacob Murrar inspects my car
I just love how my advisor Jacob Murrar inspects my car in the service drive and lifts it up to shows how everything works underneath it.
Great Car
This is my second Lexus. I originally had an ES 350 which was a wonderful car. I am very happy with the Lexus RX It drives nicely, is roomy, spacious, comfortable, and is an excellent car to own






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
That Julie is amazing.
That Julie is amazing. I was looking for a specific vehicle of LEXUS and she found the CAR. Love her and as long as she is there, I'll make her and the dealership my first choice on my next purchase.
Great vehicle!
It might be early for my review, since we have only owned the car a month; however, the Lexus has so far lived up to its reputation. I'm still getting used to all the electronics, but there are a number of safety features that enhance the driving experience.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Thank you very much Daniel Rico for the help of yours.
Thank you very much Daniel Rico for the help of yours. Making our purchase easy and quick
2022 RX 350 Premium…The last of the finest.
I bought my 2022 RX 350 Premium in February, it rides comfortably and the outward visibility is good, overall built in quality and safety features makes you feel at ease and confident on the road ahead, I’m 64 yrs old 6’2 230 lbs and both front ventilated seats are very comfortable. Don’t believe the hype of the Mark Levinson audio system which in itself an excellent addition adds up $$$ to the overall price and unless you have to drive a concert hall all day it is not needed, the built in quality HD system on the Premium suffices for most users, the added CD is a welcoming experience for an old gizzard like me and my classical CD’s. I do not care to start my vehicle using my smartphone, personally the Lexus app is not useful to me, as my choice is to start the vehicle the old fashion way key-fob in my pocket. Thus far I do not use the kick sensor for the power rear door it’s simply enough to touch the bottom on the rear tailgate. I find the touch pad user friendly, no convoluted problems using it on my 8’ inch screen, love the dials quality buttons on the 8 inch screen as well. This RX 350 2022 model is the last of the V6 smooth buttery engines with sufficient power and acceleration yet economical enough, it doesn’t require 91 octane gasoline as it is engineered to perform on 87 octane. Overall I’m very pleased with my 2022 RX 350 and plan to keep it until death keeps us apart. Thank you for reading my heartfelt review.






Used
2022 Lexus RX 350 F SPORT Appearance
Vehicle information
Features
Reviews
Mike was a pleasure to work with in the purchase of our
Mike was a pleasure to work with in the purchase of our new MDX. He answered all our questions and pointed out features and benefits of the car
Best Vehicle Ever!
I am on my 4th RX350. I love my current 350 but it is 10 years old so I’m looking to replace it. Would not consider another car. It is like new with only 79,500 miles. They are great vehicles.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Highly recommend.
Highly recommend. Greeted us with a big smile on his face. Thank you Daniel Rico for the Buick.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Absolutely the best dealership I’ve been to in years.
Absolutely the best dealership I’ve been to in years. Sebastian, my salesman found the perfect fit for me. So polite and welcoming and was so informative!! The finance manager explained everything so clearly to me! I definitely recommend this dealership to anyone in search of a great vehicle!






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Consistent and Personal
Appreciate that your service mgrs are personal in how they great and give attention to all that come. There was one service scenario I'm still processing in my head but I don't feel hesitant with sharing these thoughts right now






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Bill was very helpful and made my service appointment go
Bill was very helpful and made my service appointment go smoothly! He kept me updated on my vehicles progress. Having a loaner vehicle to get around made it stress free.






Used
2022 Lexus RX 350 F SPORT Handling
Vehicle information
Features
Reviews
My experience, was very pleasant, courteous, Derrick
My experience, was very pleasant, courteous, Derrick and Guy are the best, above board service.






Used
2022 Lexus RX 350 F SPORT Handling
Vehicle information
Features
Reviews
Sal was our salesman and I was so happy with him.
Sal was our salesman and I was so happy with him. He was patient and answered all my many questions. We were treated so well throughout the whole process, including the loan application. No stress and the car was prepped so that it looked new. Very happy.






Used
2022 Lexus RX 350 Base
Vehicle information
Features






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Go to Maria M. !
Maria M. Is a great sales woman. Answers any question honestly and is not pushy. She is knowledgeable and will go above and beyond to get the best deal for you. You feel very comfortable along the process. Left with a new car that I actually wanted.






Used
2022 Lexus RX 350 F SPORT Handling
Vehicle information
Features
Reviews
We are extremely happy with our 2024 Tesla.
We are extremely happy with our 2024 Tesla. Louis was very helpful and kind. Thank you all so much!!






Used
2022 Lexus RX 350 F SPORT Appearance
Vehicle information
Features
Reviews
Bought a 2025 Lexus TX from Dylan, easy process and quick
Bought a 2025 Lexus TX from Dylan, easy process and quick service for add-ons. I don’t even live in the area, but saw what I wanted on the internet. Drove it home next day.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Dylan was fantastic in helping me purchase my new
Dylan was fantastic in helping me purchase my new vehicle. It was a very positive experience.






Used
2022 Lexus RX 350 F SPORT Appearance
Vehicle information
Features
Reviews
I had the best car buying experience I have ever had!
I had the best car buying experience I have ever had! I cannot say enough good things about everyone that helped me. Everything went so smooth, from the paperwork, to the explanation of everything, to the time it took to get everything handled. Honestly, everything went perfectly. Every single person I interacted with at Lexus Naperville was so kind and helpful. They also really know their stuff. I asked a million questions about the car I wanted and the packages I was interested in and they were able to answer all my questions with ease. Everything was explained to me very well. I'm really glad I got them. I have with all my cars and trust me, they make the difference. Very worth it. I want to thank Kamil, Gabby, Ben and AP. If there is anyone I forgot I'm so sorry! I'm so grateful to each of them! Truly truly made the experience easy, completely stress free and I really did feel like I was in good hands. Oh also, the car I got was a used car. You wouldn't know it though. It is very clean, has no odor, and is GORGEOUS. I.LOVE.THIS.CAR. It's so fun to drive and I feel safe in it. Thank you so much!!






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Overall, very professional, progressed as a sale should,
Overall, very professional, progressed as a sale should, and they followed through on the details. Car arrived very clean, everything was included as expected. Transport service ran into some issues but they kept me in the loop and went out of their way to get the vehicle to us as quickly as they could (arrived at midnight and the driver still had 1 more stop to make, he was a nice as could be, and had no complaints - that is dedication). We are 180 miles away and Lexus of Naperville will be our new "go to" for Lexus vehicles. Closer dealers are not as transparent, and seem to be in the habit of wasting your time. It is hard to find a dealer that simply wants to sell a vehicle without playing any games. Lexus of Naperville is where you should go - ask for "Brendon" and "AP", they did a nice job. I didn't get a chance to work with her much, but Yvette was also very nice. Zach Paino from "Ship your car safely" was my contact for the transport.






Used
2022 Lexus RX 350 F SPORT Appearance
Vehicle information
Features
Reviews
Great service
Good customer service From day one I go over there to buy a car they was good with me they help me a lot even after one week from heaven the car I go back to them the car was shaking need break They help me and fix the brake for me and check the car from A-Z thank you for a good customer service






Used
2022 Lexus RX 350 Base
Vehicle information
Features
-
Prev - 1
- 2
-
Next
Lexus RX 350 prices by year
Model year | Prices from | Deals |
---|---|---|
2025 Lexus RX 350 | $55,049 | 3 Good deals |
2024 Lexus RX 350 | $51,480 | 17 Good deals |
2023 Lexus RX 350 | $45,372 | 10 Good deals |
2017 Lexus RX 350 | $17,949 | 10 Good deals |
2013 Lexus RX 350 | $10,997 | 6 Good deals |
About the 2022 Lexus RX 350
Base shown (base trim).
- Seating
- 5
- Door count
- 4
- Drivetrain
- Front-wheel drive
- Combined MPG
- 23
- Transmission
- 8-Speed A/T
- Engine
- 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

How much does the 2022 Lexus RX 350 cost?
The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $41,659, with pricing starting at $23,888.
What is the MPG of the 2022 Lexus RX 350?
The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.
These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.
What are some similar vehicles and competitors of the 2022 Lexus RX 350?
The 2022 Lexus RX 350 compares to and/or competes against the following vehicles:
Is the 2022 Lexus RX 350 reliable?
The 2022 Lexus RX 350 has an average reliability rating of 4 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.
Is the 2022 Lexus RX 350 a good SUV?
Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.
- Comfort 4.6
- Interior 4.5
- Performance 3.8
- Value 3.6
- Exterior 4.7
- Reliability 4.0
66% of drivers recommend this car
- Comfort 4.6
- Interior 4.5
- Performance 3.8
- Value 3.6
- Exterior 4.7
- Reliability 4.0
RX 350 (2 styles)
Style | |
---|---|
RX 350 FWD | RX 350 AWD |
Inventory price | |
Starting at $45,920 | Starting at $47,320 |
Combined MPG | |
23 | 22 |
Engine | |
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) | 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) |
RX 350 F SPORT Appearance (2 styles)
Style | |
---|---|
RX 350 F SPORT Appearance FWD | RX 350 F SPORT Appearance AWD |
Inventory price | |
Starting at $49,400 | Starting at $50,800 |
Combined MPG | |
23 | 22 |
Engine | |
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) | 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) |
RX 350 F SPORT Handling (2 styles)
Style | |
---|---|
RX 350 F SPORT Handling FWD | RX 350 F SPORT Handling AWD |
Inventory price | |
Starting at $51,800 | Starting at $53,200 |
Combined MPG | |
23 | 22 |
Engine | |
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) | 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) |
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
Similar Cars
-
Toyota Highlander for sale
2 Great Deals out of 38 listings starting at $25,990
Research the 2022 Lexus RX 350
Compare the 2022 Lexus RX 350
2022 Lexus RX 350 by city
-
2022 Lexus RX 350 in Robbins, IL
25 listings starting at $36,490
-
2022 Lexus RX 350 in Crestwood, IL
25 listings starting at $36,490
-
2022 Lexus RX 350 in Posen, IL
25 listings starting at $36,490
-
2022 Lexus RX 350 in Oak Forest, IL
24 listings starting at $36,490
-
2022 Lexus RX 350 in Markham, IL
24 listings starting at $36,490
-
2022 Lexus RX 350 in Dixmoor, IL
25 listings starting at $36,490
-
2022 Lexus RX 350 in Alsip, IL
26 listings starting at $36,490
-
2022 Lexus RX 350 in Blue Island, IL
25 listings starting at $36,490
-
2022 Lexus RX 350 in Hazel Crest, IL
21 listings starting at $36,490
-
2022 Lexus RX 350 in Merrionette Park, IL
26 listings starting at $36,490
-
2022 Lexus RX 350 in Country Club Hills, IL
21 listings starting at $36,490
-
2022 Lexus RX 350 in Calumet Park, IL
25 listings starting at $36,490
2022 Lexus RX 350 by body style
- ${price_badge()}
- ${ami_badge()}
- ${battery_badge()}${ev_report_link()}
- ${hot_car_badge()}
- ${award_badge()}
- ${cpo_badge()}
${price_badge_description}
${ami_badge_description}
The EV Battery Rating is based on this vehicle's current expected range relative to the vehicles expected range when new. ${battery_badge_text}
Certified cars are manufacturer warrantied and typically go through a rigorous multi-point inspection.
This car is likely to sell soon based on the price, features, and condition.
${award_blurb}
${award_two_blurb}