Save your search and get notified when new inventory arrives.
Contact seller
Customize your budget
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
About your privacy: Cars.com is asking for your ZIP and credit rating because it helps us to make an educated guess at your sales tax and loan interest. These two factors can greatly change your monthly payment.
Used
2022 Lexus RX 350
for sale
near
Rancho Santa Margarita, CA
- Down Payment
- $0
- Net trade-in value
- $0
- Months
- 72
- APR
- 7.0%
- Sales tax
- 0.0%
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Very professional and a breeze to deal with.
Very professional and a breeze to deal with...every employee was excellent...very Happy with the whole process
Love this car.
Love this car. Sitting in the driver’s seat is so comfortable. Silky smooth engine. Rides so nice and quiet. We have looked for this color Grecian water for a long time. Wanted no newer than a 2022 because we didn’t want the 4 cylinder. The 3.5 V6 runs so smooth. Would definitely recommend the purchase of this SUV.






Vehicle information
Features
Reviews
Super nice, very quick response.
The response time was really fast, I had received an email back within an hour. I was actually surprised how quick they had contacted me about my inquiry and I would recommend them to a friend
Great Car
This is my second Lexus. I originally had an ES 350 which was a wonderful car. I am very happy with the Lexus RX It drives nicely, is roomy, spacious, comfortable, and is an excellent car to own






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Frank V.
Frank V. was awesome it was smooth process. He keeps in touch so see how I?m liking my and to see if there?s anything I need with it. I can call h any time to coordinate service. Thank you Frank!
Great vehicle!
It might be early for my review, since we have only owned the car a month; however, the Lexus has so far lived up to its reputation. I'm still getting used to all the electronics, but there are a number of safety features that enhance the driving experience.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Friendly and helpful
Sale man Mohammed and the Financial Manager Dannie are very friendly and helpful. Thay were willing to help me out any problems I have, even cancel the contract without any fee and minutes. Very plased experiences.
2022 RX 350 Premium…The last of the finest.
I bought my 2022 RX 350 Premium in February, it rides comfortably and the outward visibility is good, overall built in quality and safety features makes you feel at ease and confident on the road ahead, I’m 64 yrs old 6’2 230 lbs and both front ventilated seats are very comfortable. Don’t believe the hype of the Mark Levinson audio system which in itself an excellent addition adds up $$$ to the overall price and unless you have to drive a concert hall all day it is not needed, the built in quality HD system on the Premium suffices for most users, the added CD is a welcoming experience for an old gizzard like me and my classical CD’s. I do not care to start my vehicle using my smartphone, personally the Lexus app is not useful to me, as my choice is to start the vehicle the old fashion way key-fob in my pocket. Thus far I do not use the kick sensor for the power rear door it’s simply enough to touch the bottom on the rear tailgate. I find the touch pad user friendly, no convoluted problems using it on my 8’ inch screen, love the dials quality buttons on the 8 inch screen as well. This RX 350 2022 model is the last of the V6 smooth buttery engines with sufficient power and acceleration yet economical enough, it doesn’t require 91 octane gasoline as it is engineered to perform on 87 octane. Overall I’m very pleased with my 2022 RX 350 and plan to keep it until death keeps us apart. Thank you for reading my heartfelt review.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
So. County Lexus and Enzo Impagliazzo are the best
A couple of weeks ago we acquired a 2023 Lexus RZ 450e at South County Lexus at Mission Viejo. We are so happy with the car. Our salesman, Enzo Impagliazzo did a super job selling us on the car and helping us through the whole process of acquiring it. Enzo put no pressure on us to make a decision re: purchasing the vehicle Rather, he let the vehicle sell itself, With his real title as Guest Experience Manager, he proved his worth to South County Lexus in a big way In the process of helping us in our purchase, Enzo became more than an employee of South County Lexus He became a friend A good man indeed. Bob & Glenda Vander Zaag
Best Vehicle Ever!
I am on my 4th RX350. I love my current 350 but it is 10 years old so I’m looking to replace it. Would not consider another car. It is like new with only 79,500 miles. They are great vehicles.






Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
I have been going to Wier Canyon Honda for >30 years.
I have been going to Wier Canyon Honda for >30 years. I buy my cars there and I get them serviced. Everyone is 101% professional and genuinely focused on seeing that there customers are taken care of as if they were family. I cannot recommend them more highly.






Used
2022 Lexus RX 350 Premium
Vehicle information
Features
Reviews
Great service from a courteous staff
I couldn't be happier to not find the car I was looking for but the service from the staff at this dealership. They were friendly, courteous, knowledgeable and professional. The buying process went so smooth.






Used
2022 Lexus RX 350 Base
Vehicle information
Features

Used
2022 Lexus RX 350 Base
Vehicle information
Features
Reviews
Al Khan Wad my dealer at south country lexus branch.
Al Khan Wad my dealer at south country lexus branch. just from talking to him on the phone I felt his honesty and dedicated care. I drove 2 hours to buy the car since he manage to give me a very good price and a great service. Al is one of the best , he drove my car to LA , walked me through all the steps to connect my phone to the car and more , he offered to be available for me with any future questions . He offered to drive back the next day on his day off from work to help me with paper work on selling my old car . Al fallowed up with me for 2 days to make sure I am all being taking care . I highly recommend Al one of a kind dealer at Lexus of south country branch . Thank you Al for great service and great experience. Best regards Edna B.
Vehicle information
Features
Used
2022 Lexus RX 350 F SPORT Handling
Vehicle information
Features
Reviews
Super easy sales process
Met up with salesman Ed Ringler and what a great buying experience! Thank you Ed! I’m recommending everyone I know to come see u! Thank you once again!!!






Vehicle information
Features
Reviews
Thanks to Kelvin for his professionalism service, he is
Thanks to Kelvin for his professionalism service, he is knowledgeable, patient, and attentive, taking the time to understand my needs and answer all my questions. The entire process was smooth, stress-free, and transparent.
There are 20 matching cars close to your year range.






Certified
2023 Lexus RX 350 Premium
Vehicle information
Features






Used
2023 Lexus RX 350 Premium
Vehicle information
Features






Used
2024 Lexus RX 350 Premium
Vehicle information
Features






Vehicle information
Features






Used
2023 Lexus RX 350 Premium Plus
Vehicle information
Features






Used
2021 Lexus RX 350 F SPORT Performance
Vehicle information
Features






Certified
2023 Lexus RX 350 Base
Vehicle information
Features






Certified
2023 Lexus RX 350 Premium
Vehicle information
Features






Used
2023 Lexus RX 350 Premium
Vehicle information
Features






Vehicle information
Features






Certified
2024 Lexus RX 350 Premium
Vehicle information
Features






Used
2020 Lexus RX 350 Base
Vehicle information
Features






Used
2023 Lexus RX 350 Premium Plus
Vehicle information
Features






Used
2020 Lexus RX 350 Base
Vehicle information
Features






Certified
2024 Lexus RX 350 Premium
Vehicle information
Features






Certified
2023 Lexus RX 350 Premium Plus
Vehicle information
Features






Certified
2024 Lexus RX 350 Premium Plus
Vehicle information
Features






Used
2023 Lexus RX 350 Premium
Vehicle information
Features






Certified
2024 Lexus RX 350 Premium
Vehicle information
Features






Used
2023 Lexus RX 350 Premium Plus
Vehicle information
Features
-
Prev - 1
-
Next
Lexus RX 350 prices by year
Model year | Prices from | Deals |
---|---|---|
2025 Lexus RX 350 | $47,829 | |
2024 Lexus RX 350 | $46,499 | 5 Good deals |
2023 Lexus RX 350 | $41,598 | 3 Good deals |
2015 Lexus RX 350 | $9,999 | 4 Good deals |
About the 2022 Lexus RX 350
Base shown (base trim).
- Seating
- 5
- Door count
- 4
- Drivetrain
- Front-wheel drive
- Combined MPG
- 23
- Transmission
- 8-Speed A/T
- Engine
- 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

How much does the 2022 Lexus RX 350 cost?
The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $41,110, with pricing starting at $28,699.
What is the MPG of the 2022 Lexus RX 350?
The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.
These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.
What are some similar vehicles and competitors of the 2022 Lexus RX 350?
The 2022 Lexus RX 350 compares to and/or competes against the following vehicles:
Is the 2022 Lexus RX 350 reliable?
The 2022 Lexus RX 350 has an average reliability rating of 4 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.
Is the 2022 Lexus RX 350 a good SUV?
Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.
- Comfort 4.6
- Interior 4.5
- Performance 3.8
- Value 3.6
- Exterior 4.7
- Reliability 4.0
66% of drivers recommend this car
- Comfort 4.6
- Interior 4.5
- Performance 3.8
- Value 3.6
- Exterior 4.7
- Reliability 4.0
RX 350 (2 styles)
Style | |
---|---|
RX 350 FWD | RX 350 AWD |
Inventory price | |
Starting at $45,920 | Starting at $47,320 |
Combined MPG | |
23 | 22 |
Engine | |
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) | 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) |
RX 350 F SPORT Appearance (2 styles)
Style | |
---|---|
RX 350 F SPORT Appearance FWD | RX 350 F SPORT Appearance AWD |
Inventory price | |
Starting at $49,400 | Starting at $50,800 |
Combined MPG | |
23 | 22 |
Engine | |
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) | 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) |
RX 350 F SPORT Handling (2 styles)
Style | |
---|---|
RX 350 F SPORT Handling FWD | RX 350 F SPORT Handling AWD |
Inventory price | |
Starting at $51,800 | Starting at $53,200 |
Combined MPG | |
23 | 22 |
Engine | |
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) | 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) |
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
Similar Cars
-
Mercedes-Benz GLE 350 for sale
3 Great Deals out of 45 listings starting at $30,799
-
Toyota Highlander for sale
4 Great Deals out of 28 listings starting at $25,957
Research the 2022 Lexus RX 350
Compare the 2022 Lexus RX 350
2022 Lexus RX 350 by city
-
2022 Lexus RX 350 in Lake Forest, CA
20 listings starting at $31,999
-
2022 Lexus RX 350 in Irvine, CA
20 listings starting at $31,999
-
2022 Lexus RX 350 in Tustin, CA
22 listings starting at $31,999
-
2022 Lexus RX 350 in North Tustin, CA
22 listings starting at $31,999
-
2022 Lexus RX 350 in Newport Beach, CA
20 listings starting at $32,951
-
2022 Lexus RX 350 in Coronita, CA
22 listings starting at $31,999
- ${price_badge()}
- ${ami_badge()}
- ${battery_badge()}${ev_report_link()}
- ${hot_car_badge()}
- ${award_badge()}
- ${cpo_badge()}
${price_badge_description}
${ami_badge_description}
The EV Battery Rating is based on this vehicle's current expected range relative to the vehicles expected range when new. ${battery_badge_text}
This vehicle is certified pre-owned, backed by a manufacturer warranty, and typically undergoes a rigorous multi-point inspection to ensure quality and reliability.
This vehicle is currently in high demand given its competitive price, desirable features, and overall condition, and may have a higher chance of selling quickly.