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*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
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Used
2021 Mercedes-Benz S-Class
for sale
near
North Potomac, MD
- Down Payment
- $0
- Net trade-in value
- $0
- Months
- 72
- APR
- 7.0%
- Sales tax
- 0.0%
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
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Reviews
Chip and the crew at Universal Auto were top notch.
Chip and the crew at Universal Auto were top notch. I was an out of state buyer and they made the process super easy. The car was immaculate and I could not be more pleased. Will recommend them to friends and family.
Franklin is great.
Franklin is great. Thank you for your support help and patience with me. Love the car. At rides great. The paperwork and process was fast
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
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Reviews
I came for an Oil change and safety inspection, Alfred
I came for an Oil change and safety inspection, Alfred helped me, he was very friendly, knowledgeable and got me out in no time! Always a good service at Koons. Thank you!
Love my Mercedes
I have been driving Mercedes Benz s class vehicles for over 10 years, traded every 3-4 years and have been very happy, always have them serviced at the dealer, always received a loaner, no complaints.
Mercedes-Benz Certified
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
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Reviews
Ted Shepherd at Germantown EuroMotors
Ted Shepherd is the kind of salesperson every car buyer hopes to find. He listens patiently and answers questions with honesty and integrity. It was a pleasure to work with Ted. He did not ask me to write this review. I was motivated by my appreciation for the experience.
An Absolute Dream
I have owned 6 S Class (SonderKlas) cars in my life and each and every single one has been problem free and a pure joy to own, drive, and admire. The 2021 S580 however.. Well this car is truly something special and not an incremental upgrade! This thing is crazy
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
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Reviews
My boyfriend had been looking for long time to find
My boyfriend had been looking for long time to find another beautiful, unique Mercedes with specific features, and we finally found it about 4 hrs driving from NYC. What a great experience we had purchasing a convertible Mercedes with Chip, professional, kind, knowledgeable Salesperson! It was a beautiful day of September, 2024, perfect time to drive a convertible car! Since then, we've been enjoying more the beauty of weekends , the symphony of autumn colors, traveling in many places under no sky limits... With the indoor showroom, every car is clean, all of them look impacable! Everything is no pressure, they paid attention to our questions. The finance lady is awesome, especially in our case as a cash buyer. She made my partner feel very comfortable about purchase process . We would definitely drive another 3.5 -4 hours to make another purchase with Chip, MD, when I'll decide to change my car. Chip and his Team do outstanding job! I highly recommend him to get your DREAM car, you won't regret making your decision. Thank you, Chip! You rock!
Luxury
Luxury at its best, you can’t get better than that with this price range. S 580 is the way to go, the 8 cylinders are so smooth yet so sporty. This car can be Rolls Royce luxury and lamborghini urus if it wants
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
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The way car buying should be..
The way car experience should be. Outstanding customer service provided by Sales Consultant named Hassan. Will definitely recommend Hassan at this dealership for friends, families and associates. Kudos!
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
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Reviews
Peter was Amazing at taking care of my car from the
Peter was Amazing at taking care of my car from the beginning to the end. Extremely professional and knowledge
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Awesome deal.
Excellent service from the first contact, they are the best, I will definitely buy from them again, It is simply a great purchasing experience 100% Satisfied.
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Didn’t buy from them but the sales rep was responsive and
Didn’t buy from them but the sales rep was responsive and knowledgeable. The price on the car seemed fair.
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
Features
Reviews
Refreshing !
Refreshing ! I brought a SL550 Benz , worked with Mason best experience from a car dealership I had to date, from the first day I called to last day out the door with the car . They waited on me and for me & I appreciate that highly recommended. Shot out to Haas & Chris! Sending all friend & fam. Mr & Mrs Mark F.
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
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Reviews
AWESOME DEALERSHIP AND STAFF❣️ GREAT SELECTIONS 2 CHOOSE
AWESOME DEALERSHIP AND STAFF❣️ GREAT SELECTIONS 2 CHOOSE FROM🚘🚙 THANK U 4 MY NEW SUV🚙🤍💃🏽🥳🎉
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
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I post a review on June 7 2025 and today July 26, 2025 we
I post a review on June 7 2025 and today July 26, 2025 we had meeting with the manager James and he settled the price issue we had with the purchase of Honda civic 2016. Thank you James
Used
2021 Mercedes-Benz S-Class S 580 4MATIC
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Reviews
Look no further.
We needed a car and had a budget to stick to. Joey and Abdur were great. We saw 6 different vehicles. They help us wade through the Carfax reports and choose a car with no "baggage" in its past. The two salesmen were very professional and patient as we chose our vehicle. Simply the best. Planning to go back when I need another vehicle in the future.
Used
2021 Mercedes-Benz S-Class S 500 4MATIC
Vehicle information
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Used
2021 Mercedes-Benz S-Class S 580 4MATIC
Vehicle information
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Reviews
I just bought a preowned Mercedes from Kingstowne
I just bought a preowned Mercedes from Kingstowne MotorCars. This was by far the best auto buying experience I’ve had. They specialize in preowned luxury cars. Every car on the lot was immaculate. The guys are very professional yet provided a comfortable, stress-free environment. There was absolutely no pressure at all. Ali is my new favorite salesman. And Patrick made the transaction flawless. When I took delivery of the car they had the state safety inspection and the emissions inspection complete. I asked what documents I needed to take to the DMV. Patrick said I didn’t need to go to the DMV. They took care of everything and my plates arrived at my house three days later. They had even attached the expiration stickers to the plate. I can hardly wait to buy my next car from them.
There are 20 matching cars close to your year range.
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2023 Mercedes-Benz S-Class S 580 4MATIC
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2022 Mercedes-Benz S-Class S 580 4MATIC
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2022 Mercedes-Benz S-Class 4MATIC
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Mercedes-Benz Certified
2022 Mercedes-Benz S-Class S 500 4MATIC
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Used
2022 Mercedes-Benz S-Class S 580 4MATIC
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Used
2022 Mercedes-Benz S-Class 4MATIC
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Used
2022 Mercedes-Benz S-Class S 580 4MATIC
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Mercedes-Benz S-Class prices by year
| Model year | Average price | Deals |
|---|---|---|
| 2026 Mercedes-Benz S-Class | $147,403 | |
| 2022 Mercedes-Benz S-Class | $67,860 | 6 Great deals |
| 2015 Mercedes-Benz S-Class | $29,247 | 6 Great deals |
About the 2021 Mercedes-Benz S-Class
S 500 4MATIC shown (base trim).
- Seating
- 5
- Door count
- 4
- Drivetrain
- All-wheel Drive
- Combined MPG
- 24
- Transmission
- 9-Speed A/T
- Engine
- 429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
How much does the 2021 Mercedes-Benz S-Class cost?
The 2021 Mercedes-Benz S-Class price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 S-Class is $61,754, with pricing starting at $45,444.
What is the MPG of the 2021 Mercedes-Benz S-Class?
The 2021 Mercedes-Benz S-Class offers up to 20 MPG in city driving and 29 MPG on the highway for a combined rating of 24 MPG.
These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.
What are some similar vehicles and competitors of the 2021 Mercedes-Benz S-Class?
The 2021 Mercedes-Benz S-Class compares to and/or competes against the following vehicles:
Is the 2021 Mercedes-Benz S-Class reliable?
The 2021 Mercedes-Benz S-Class has an average reliability rating of 5 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 S-Class owners.
Is the 2021 Mercedes-Benz S-Class a good sedan?
Below are the Cars.com consumer ratings for the 2021 Mercedes-Benz S-Class.
- Comfort 5.0
- Interior 5.0
- Performance 5.0
- Value 4.8
- Exterior 5.0
- Reliability 5.0
100% of drivers recommend this car
- Comfort 5.0
- Interior 5.0
- Performance 5.0
- Value 4.8
- Exterior 5.0
- Reliability 5.0
S 500 (1 style)
| Style |
|---|
| S 500 4MATIC Sedan |
| Inventory price |
| Starting at $109,800 |
| Combined MPG |
| 24 |
| Engine |
| 429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) |
S 560 (2 styles)
| Style | |
|---|---|
| S 560 Cabriolet | S 560 4MATIC Coupe |
| Inventory price | |
| Starting at $140,000 | Starting at $131,400 |
| Combined MPG | |
| 20 | 20 |
| Engine | |
| 463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel) | 463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel) |
S 580 (1 style)
| Style |
|---|
| S 580 4MATIC Sedan |
| Inventory price |
| Starting at $116,300 |
| Combined MPG |
| 20 |
| Engine |
| 496.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline/Mild Electric Hybrid) |
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
Research the 2021 Mercedes-Benz S-Class
Compare the 2021 Mercedes-Benz S-Class
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This vehicle is certified pre-owned, backed by a manufacturer warranty, and typically undergoes a rigorous multi-point inspection to ensure quality and reliability.
This vehicle is currently in high demand given its competitive price, desirable features, and overall condition, and may have a higher chance of selling quickly.
