Skip to main content
Best match Lowest price Highest price Lowest mileage Highest mileage Nearest location Best deal Newest year Oldest year Newest listed Oldest listed
Skip to Filters
  • Gy 2021 Lexus IS 350 BaseGy 2021 Lexus IS 350 BaseGy 2021 Lexus IS 350 BaseGy 2021 Lexus IS 350 BaseGy 2021 Lexus IS 350 BaseGy 2021 Lexus IS 350 Base

    $40,969

    15,746 mi.
    Est. $760/mo

    Toyota of Massapequa

    4.7
    Check Availability
    Seaford, NY (27 mi)
    Quick view
  • Ultra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 Base

    $29,995

    $1.4K
    77,810 mi.
    Est. $557/mo

    Convey Motors

    5.0
    Check Availability
    Hillside, NJ (15 mi)
    Quick view
  • Caviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 Base

    $34,995

    76,547 mi.
    Est. $650/mo

    MotorHub Inc.

    Check Availability
    Inwood, NY (18 mi)
    Quick view
  • Ultra White (083) 2021 Lexus IS 350 BaseUltra White (083) 2021 Lexus IS 350 BaseUltra White (083) 2021 Lexus IS 350 BaseUltra White (083) 2021 Lexus IS 350 BaseUltra White (083) 2021 Lexus IS 350 BaseUltra White (083) 2021 Lexus IS 350 Base

    $41,488

    25,034 mi.
    Est. $770/mo

    Auto Club of Edison

    2.9
    Check Availability
    Edison, NJ (30 mi)
    Quick view
  • White 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-Sport

    $34,998

    56,614 mi.
    Est. $650/mo

    CarMax Virginia Beach

    Check Availability
    $199 delivery to Wayne, NJ (19 mi)
    Quick view
  • Atomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 Base

    $34,735

    $400
    48,223 mi.
    Est. $645/mo

    Kernersville Chrysler Dodge Jeep RAM

    4.3
    Check Availability
    $2,216 delivery from Kernersville, NC (462 mi)
    Quick view
  • Ultra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 Base

    $32,889

    100,246 mi.
    Est. $610/mo

    Pohanka Lexus

    3.8
    Check Availability
    Chantilly, VA (226 mi)
    Quick view
  • Ultra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 BaseUltra White 2021 Lexus IS 350 Base

    $30,900

    58,093 mi.
    Est. $574/mo

    House Of Cars

    4.3
    Check Availability
    Edison, NJ (31 mi)
    Quick view
  • Silver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 Base

    $25,995

    182,460 mi.
    Est. $483/mo

    Car Connect

    Check Availability
    Stafford, VA (243 mi)
    Quick view
  • Atomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 BaseAtomic Silver 2021 Lexus IS 350 Base

    $40,566

    39,709 mi.
    Est. $753/mo

    Pohanka Lexus

    3.8
    Check Availability
    Chantilly, VA (226 mi)
    Quick view
  • $36,950

    49,413 mi.
    Est. $686/mo

    Bobby Rahal Lexus

    Check Availability
    Mechanicsburg, PA (167 mi)
    Quick view

Lexus IS 350 prices by year

Model year Average price Deals
2026 Lexus IS 350 $54,578
2025 Lexus IS 350 $50,948 1 Good deal
2023 Lexus IS 350 $40,176 7 Good deals

About the 2021 Lexus IS 350

Basics

F Sport shown (base trim).

Seating
5
Door count
4
Drivetrain
Rear-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
311.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Lexus IS 350
FAQs

How much does the 2021 Lexus IS 350 cost?

The 2021 Lexus IS 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 IS 350 is $36,060, with pricing starting at $25,995.

What is the MPG of the 2021 Lexus IS 350?

The 2021 Lexus IS 350 offers up to 20 MPG in city driving and 28 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Lexus IS 350?

The 2021 Lexus IS 350 compares to and/or competes against the following vehicles:


Is the 2021 Lexus IS 350 reliable?

The 2021 Lexus IS 350 has an average reliability rating of 5 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 IS 350 owners.

Is the 2021 Lexus IS 350 a good sedan?

Below are the Cars.com consumer ratings for the 2021 Lexus IS 350.

(2 reviews)
Rating breakdown (out of 5):
Comfort
5.0
Interior
4.5
Performance
5.0
Value
4.5
Exterior
5.0
Reliability
5.0
Ratings (2 reviews)

100% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
5.0
Interior
4.5
Performance
5.0
Value
4.5
Exterior
5.0
Reliability
5.0
Trims

IS 350 F SPORT (2 styles)

Style
IS 350 F SPORT RWD IS 350 F SPORT AWD
Inventory price
Starting at $42,950 Starting at $44,950
Combined MPG
23 22
Engine
311.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 311.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Skip to Listings
Best match Lowest price Highest price Lowest mileage Highest mileage Nearest location Best deal Newest year Oldest year Newest listed Oldest listed