Save your search and get notified when new inventory arrives.
Contact seller
Customize your budget
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
About your privacy: Cars.com is asking for your ZIP and credit rating because it helps us to make an educated guess at your sales tax and loan interest. These two factors can greatly change your monthly payment.
Used
2021 Lexus RX 350
for sale
near
Tustin, CA
- Down Payment
- $0
- Net trade-in value
- $0
- Months
- 72
- APR
- 7.0%
- Sales tax
- 0.0%
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.






Used
2021 Lexus RX 350 Base
Vehicle information
Features
Reviews
The Sales Person I dealt with in AutoNation Irvine was
The Sales Person I dealt with in AutoNation Irvine was excellent. He went above and beyond in making sure I had all my concerns covered. He even called me two days later to make sure I am happy with my purchase. The one thing that was disappointing is the car I purchased came with one key, I asked for the second but the sales manager and the finance lady didn't want to give me that. I don't understand why they don't make one and keep the customer happy. They make a big deal of creating a copy of the key although it is not really that big for a dealership like AutoNation
RX is the Best !
This 2021 RX is a great vehicle, everything about the RX is high quality, quiet, quick, smooth, well built. Only complaint is cabin is built so tight that I farted in car at airport parking lot. Came back two weeks later from a trip overseas and it still stunk inside.






Used
2021 Lexus RX 350 Base
Vehicle information
Features
Reviews
It was a great experience Jerry Gonzalez made everything
It was a great experience Jerry Gonzalez made everything about buying my car so easy and smooth that I will return just because of him
Love my New Lexus RX 350!
I love my new RX350! I love the Atomic silver and the styling. The technology is not real user friendly, but it can do a lot! It’s nice to drive, since it is so quiet and smooth riding. I paid cash but still hand to pay full retail price for the Certified 2021 with low miles. The dealership in Tulsa was great, though.






Used
2021 Lexus RX 350 Base
Vehicle information
Features
Reviews
Always professional and helpful to ensure that you get
Always professional and helpful to ensure that you get quality service and assistance. Have done business with them since purchasing our first Lexus in 1992. They never disappoint.
Lexus RX 350 great car!
This is the 2021 Lexus RX 350 and is my 4th Lexus and I love it! The 2018 was also really great and so was the 2015. I think the price is very good and the value is incredible because either way, either leasing rates are great due to the high residual values, and the buy rates are great because you could sell your car used because they are very much in demand and you get a lot for it. If you hold onto your Lexus, that's another great option, because the Lexus engine is incredible, built to protect the engine and last a very long time! I have not had any issues with any of my Lexus ((unlike other car brands -I have had issues with other cars warning lights, electrical, rotors, struts, sensor issues, and faulty parts, and check engine light and other quirks etc!!!)) I totally recommend Lexus -very reliable and no problems! Servicing is always reasonable too!






Used
2021 Lexus RX 350 Base
Vehicle information
Features
Reviews
It was a great experience from beginning to end.
It was a great experience from beginning to end. I got exactly what I wanted and it was delivered to me in perfect condition. I can’t thank them enough.
My choice in ultimate Luxury.
I compared the Lexus Luxury trim model feature for feature with 3 other top Luxury cars. The Lexus offered me much more. On top of that is it’s phenomenal reliability rating. I believe its the smoothest, quietest, driving car of the brands, too!






Vehicle information
Features
Reviews
Frank V.
Frank V. was awesome it was smooth process. He keeps in touch so see how I?m liking my and to see if there?s anything I need with it. I can call h any time to coordinate service. Thank you Frank!
Most Comfortable car I have owned
The car met all my needs. It has a good exterior style. It has very smooth running. The electronics are top class. It is user friendly without making it too complicated to operate.






Used
2021 Lexus RX 350 Base
Vehicle information
Features
Reviews
Bruce was absolutely wonderful.
Bruce was absolutely wonderful. From the discussion on the phone all the way to the finance office was great!! We bought used and certified. I was between two CRV (one at another dealer) and with the way Bruce was communicating and working for me, I chose correctly. I absolutely love my car and this was the easiest process purchasing a car in my life.
Vehicle information
Features
Reviews
Very professional and a breeze to deal with.
Very professional and a breeze to deal with...every employee was excellent...very Happy with the whole process

Used
2021 Lexus RX 350 F SPORT Handling
Vehicle information
Features
Reviews
Al Khan Wad my dealer at south country lexus branch.
Al Khan Wad my dealer at south country lexus branch. just from talking to him on the phone I felt his honesty and dedicated care. I drove 2 hours to buy the car since he manage to give me a very good price and a great service. Al is one of the best , he drove my car to LA , walked me through all the steps to connect my phone to the car and more , he offered to be available for me with any future questions . He offered to drive back the next day on his day off from work to help me with paper work on selling my old car . Al fallowed up with me for 2 days to make sure I am all being taking care . I highly recommend Al one of a kind dealer at Lexus of south country branch . Thank you Al for great service and great experience. Best regards Edna B.

Used
2021 Lexus RX 350 Base
Vehicle information
Features
Reviews
Smooth transaction and all the staff are very friendly.
Smooth transaction and all the staff are very friendly. My salesman that assisted me George was very helpful. Will do business again,
There are 20 matching cars close to your year range.






Used
2022 Lexus RX 350 Base
Vehicle information
Features






Used
2022 Lexus RX 350 Premium
Vehicle information
Features






Used
2023 Lexus RX 350 Premium
Vehicle information
Features






Used
2023 Lexus RX 350 Premium
Vehicle information
Features






Used
2019 Lexus RX 350 F Sport
Vehicle information
Features






Used
2019 Lexus RX 350 350
Vehicle information
Features






Used
2022 Lexus RX 350 Base
Vehicle information
Features






Vehicle information
Features






Used
2023 Lexus RX 350 Premium
Vehicle information
Features
Used
2022 Lexus RX 350 Base
Vehicle information
Features






Used
2022 Lexus RX 350 Base
Vehicle information
Features






Vehicle information
Features






Vehicle information
Features






Used
2023 Lexus RX 350 Premium Plus
Vehicle information
Features






Used
2019 Lexus RX 350 Base
Vehicle information
Features






Used
2023 Lexus RX 350 Premium
Vehicle information
Features






Vehicle information
Features






Used
2022 Lexus RX 350 Base
Vehicle information
Features






Vehicle information
Features






Vehicle information
Features
-
Prev - 1
-
Next
Lexus RX 350 prices by year
Model year | Prices from | Deals |
---|---|---|
2025 Lexus RX 350 | $48,495 | 2 Good deals |
2024 Lexus RX 350 | $41,506 | 10 Good deals |
2023 Lexus RX 350 | $41,991 | 6 Good deals |
2022 Lexus RX 350 | $32,995 | 8 Good deals |
2019 Lexus RX 350 | $25,888 | 8 Good deals |
2017 Lexus RX 350 | $19,998 | 8 Good deals |
About the 2021 Lexus RX 350
Base shown (base trim).
- Seating
- 5
- Door count
- 4
- Drivetrain
- Front-wheel drive
- Combined MPG
- 23
- Transmission
- 8-Speed A/T
- Engine
- 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

How much does the 2021 Lexus RX 350 cost?
The 2021 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 RX 350 is $36,959, with pricing starting at $25,995.
What is the MPG of the 2021 Lexus RX 350?
The 2021 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.
These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.
What are some similar vehicles and competitors of the 2021 Lexus RX 350?
The 2021 Lexus RX 350 compares to and/or competes against the following vehicles:
Is the 2021 Lexus RX 350 reliable?
The 2021 Lexus RX 350 has an average reliability rating of 4.8 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 RX 350 owners.
Is the 2021 Lexus RX 350 a good SUV?
Below are the Cars.com consumer ratings for the 2021 Lexus RX 350.
- Comfort 4.7
- Interior 4.7
- Performance 4.7
- Value 4.6
- Exterior 4.6
- Reliability 4.8
88% of drivers recommend this car
- Comfort 4.7
- Interior 4.7
- Performance 4.7
- Value 4.6
- Exterior 4.6
- Reliability 4.8
RX 350 (2 styles)
Style | |
---|---|
RX 350 AWD | RX 350 FWD |
Inventory price | |
Starting at $46,620 | Starting at $45,220 |
Combined MPG | |
22 | 23 |
Engine | |
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) | 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) |
RX 350 F SPORT Appearance (2 styles)
Style | |
---|---|
RX 350 F SPORT Appearance FWD | RX 350 F SPORT Appearance AWD |
Inventory price | |
Starting at $48,700 | Starting at $50,100 |
Combined MPG | |
23 | 22 |
Engine | |
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) | 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) |
RX 350 F SPORT Handling (2 styles)
Style | |
---|---|
RX 350 F SPORT Handling AWD | RX 350 F SPORT Handling FWD |
Inventory price | |
Starting at $52,500 | Starting at $51,100 |
Combined MPG | |
22 | 23 |
Engine | |
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) | 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) |
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
Similar Cars
-
Mercedes-Benz GLE 350 for sale
4 Great Deals out of 21 listings starting at $26,495
-
Toyota Highlander for sale
2 Great Deals out of 21 listings starting at $24,450
Research the 2021 Lexus RX 350
Compare the 2021 Lexus RX 350
- ${price_badge()}
- ${ami_badge()}
- ${battery_badge()}${ev_report_link()}
- ${hot_car_badge()}
- ${award_badge()}
- ${cpo_badge()}
${price_badge_description}
${ami_badge_description}
The EV Battery Rating is based on this vehicle's current expected range relative to the vehicles expected range when new. ${battery_badge_text}
This vehicle is certified pre-owned, backed by a manufacturer warranty, and typically undergoes a rigorous multi-point inspection to ensure quality and reliability.
This vehicle is currently in high demand given its competitive price, desirable features, and overall condition, and may have a higher chance of selling quickly.