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Used 2022 Lexus RX 350 Base for sale near Milwaukee, WI

Filters 5 Year Trim Model Price & payment Make Mileage All filters
1 match 30 miles from 53210
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Est. $400 /mo*
Down Payment
$0
Net trade-in value
$0
Months
72
APR
7.0%
Sales tax
0.0%

*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.

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2022 Lexus RX 350 Base
2022 Lexus RX 350 Base
2022 Lexus RX 350 Base
2022 Lexus RX 350 Base
2022 Lexus RX 350 Base
2022 Lexus RX 350 Base View all 35 photos

Used

2022 Lexus RX 350 Base

41,801 mi.
$40,797 $200 price drop
Est. $750/mo*
Wilde Honda
(1,272 reviews)
Waukesha, WI (12 mi.)
Call Check availability Check availability

Vehicle information

Ext. color: Eminent White Pearl
Int. color: Parchment
Drivetrain: Front-wheel Drive
MPG: 20-27
Fuel type: Gasoline
Transmission: Automatic
Engine: 3.5L V-6 port/direct injection, DOHC, VVT-iW variable valve cont
Stock #: NC244261A
VIN: 2T2HZMAA7NC244261

Features

Convenience: Adaptive Cruise Control, Cooled Seats, Heated Seats, Heated Steering Wheel, Keyless Entry, Keyless Start, Navigation System, Power Liftgate, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, CD Player, HomeLink, Premium Sound System, Satellite Radio, USB Port, WiFi Hotspot
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Automatic Emergency Braking, Backup Camera, Blind Spot Monitor, Brake Assist, LED Headlights, Lane Departure Warning, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Leather Seats, Memory Seat

Reviews

Wilde Honda review

We are from the Fox Valley and have purchased a few

September 1, 2025
By Kathy J from Neenah, WI

We are from the Fox Valley and have purchased a few vehicles from Wilde in the past and are willing to take the drive because of the excellent experience we receive and this time was no different. Paul Basile met us as soon as we got out of our vehicle (it was Labor day weekend so it was crazy busy) and we are glad he chose us. He was extremely knowledgable on the Ridgelines which was exactly what we came for. He didn’t waste our time, gave us options and got us test driving quickly. We found ‘the one’ that was right for us. Paul made sure we had everything we needed and was great to chat with while waiting for finance to do their thing. I highly recommend working with Paul!

2022 Lexus RX 350 Base review

Love this car.

July 23, 2025
By Tmck from GEORGIA
Owns this car

Love this car. Sitting in the driver’s seat is so comfortable. Silky smooth engine. Rides so nice and quiet. We have looked for this color Grecian water for a long time. Wanted no newer than a 2022 because we didn’t want the 4 cylinder. The 3.5 V6 runs so smooth. Would definitely recommend the purchase of this SUV.

There are 4 matching cars close to your year range.

2021 Lexus RX 350 Base
2021 Lexus RX 350 Base
2021 Lexus RX 350 Base
2021 Lexus RX 350 Base
2021 Lexus RX 350 Base
2021 Lexus RX 350 Base View all 36 photos

Used

2021 Lexus RX 350 Base

98,389 mi.
$26,999 $356 price drop
Est. $497/mo*
Wilde Honda
(1,272 reviews)
Waukesha, WI (12 mi.)
Call Check availability Check availability

Vehicle information

Ext. color: Nebula Gray Pearl
Int. color: Parchment
Drivetrain: All-wheel Drive
MPG: 19-26
Fuel type: Gasoline
Transmission: Automatic
Engine: 3.5L V-6 port/direct injection, DOHC, VVT-iW variable valve cont
Stock #: MC285437P
VIN: 2T2HZMDA0MC285437

Features

Convenience: Adaptive Cruise Control, Cooled Seats, Heated Seats, Heated Steering Wheel, Keyless Entry, Keyless Start, Power Liftgate, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, CD Player, HomeLink, Satellite Radio, USB Port, WiFi Hotspot
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Automatic Emergency Braking, Backup Camera, Blind Spot Monitor, Brake Assist, LED Headlights, Lane Departure Warning, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Leather Seats, Memory Seat
2024 Lexus RX 350 Base
2024 Lexus RX 350 Base
2024 Lexus RX 350 Base
2024 Lexus RX 350 Base
2024 Lexus RX 350 Base
2024 Lexus RX 350 Base View all 37 photos

Certified

2024 Lexus RX 350 Base

24,106 mi.
$48,698 $1,300 price drop
Est. $896/mo*
Lexus of Brookfield
Brookfield, WI (10 mi.)
Call Check availability Check availability

Vehicle information

Ext. color: Eminent White Pearl
Int. color: Black w/Black Cascade Trim
Drivetrain: All-wheel Drive
MPG: 21-28
Fuel type: Gasoline
Transmission: Automatic
Engine: 2.4L I-4 port/direct injection, DOHC, variable valve control, in
Stock #: PJP2929
VIN: 2T2BAMCA1RC079596

Features

Convenience: Adaptive Cruise Control, Heated Seats, Heated Steering Wheel, Keyless Entry, Keyless Start, Navigation System, Power Liftgate, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, HomeLink, USB Port
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Automatic Emergency Braking, Backup Camera, Blind Spot Monitor, Brake Assist, LED Headlights, Lane Departure Warning, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Leather Seats
2023 Lexus RX 350 Premium Plus
2023 Lexus RX 350 Premium Plus
2023 Lexus RX 350 Premium Plus
2023 Lexus RX 350 Premium Plus
2023 Lexus RX 350 Premium Plus
2023 Lexus RX 350 Premium Plus View all 36 photos

Certified

2023 Lexus RX 350 Premium Plus

67,345 mi.
$42,183 $179 price drop
Est. $776/mo*
Lexus of Milwaukee
Milwaukee, WI (5 mi.)
Call Check availability Check availability

Vehicle information

Ext. color: Iridium
Int. color: Black w/Black Open Pore
Drivetrain: All-wheel Drive
MPG: 37-34
Fuel type: Gasoline
Transmission: Automatic
Engine: 2.5L I-4 port/direct injection, DOHC, VVT-iE/VVT-i variable valv
Stock #: L21486A
VIN: 2T2BBMCA5PC003776

Features

Convenience: Adaptive Cruise Control, Cooled Seats, Heated Seats, Keyless Entry, Keyless Start, Navigation System, Power Liftgate, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, HomeLink, USB Port
Exterior: Alloy Wheels, Roof Rack, Sunroof/Moonroof
Safety: Automatic Emergency Braking, Backup Camera, Blind Spot Monitor, Brake Assist, LED Headlights, Lane Departure Warning, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Memory Seat
No photo available

Used

2020 Lexus RX 350 Base

109,934 mi.
$29,995
Est. $552/mo*
Wilde Toyota
West Allis, WI (7 mi.)
Call Check availability Check availability

Vehicle information

Ext. color: Black
Int. color: Black
Drivetrain: All-wheel Drive
MPG: 19-26
Fuel type: Gasoline
Transmission: 8-Speed Automatic
Engine: 3.5L V6 DOHC 24V
Stock #: 93756A
VIN: 2T2HZMDA4LC224364

Features

Convenience: Adaptive Cruise Control, Cooled Seats, Heated Seats, Heated Steering Wheel, Keyless Entry, Keyless Start, Navigation System, Power Liftgate, Remote Start
Entertainment: Android Auto®, Apple CarPlay®, Bluetooth®, CD Player, HomeLink, Premium Sound System, USB Port, WiFi Hotspot
Exterior: Alloy Wheels, Sunroof/Moonroof
Safety: Automatic Emergency Braking, Backup Camera, Blind Spot Monitor, Brake Assist, LED Headlights, Lane Departure Warning, Rain Sensing Wipers, Rear Cross Traffic Alert, Stability Control
Seating: Leather Seats, Memory Seat
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About the 2022 Lexus RX 350 Base

Basics

Base shown.

Seating
5
Door count
4
Drivetrain
Front Wheel Drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350 Base
FAQs

How much does the 2022 Lexus RX 350 Base cost?

The 2022 Lexus RX 350 Base price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 Base is $38,982, with pricing starting at $27,450.

What is the MPG of the 2022 Lexus RX 350 Base?

The 2022 Lexus RX 350 Base offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Lexus RX 350 Base?

The 2022 Lexus RX 350 Base compares to and/or competes against the following vehicles:

Is the 2022 Lexus RX 350 Base reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.

**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.

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Basics
Lexus models
RX 350 trims
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‡Monthly budget search results are estimated based on a 72-month loan term with $0 down payment, $0 trade-in value, 0.0% sales tax and 7.0% APR. Inputs can be personalized using the calculator.
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