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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $38,990

    50,563 mi.
    Est. $715/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (13 mi)

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  • White 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 Base

    $35,691

    46,566 mi.
    Est. $654/mo

    Chrysler Dodge Jeep Ram of Tampa Bay

    4.1
    Check Availability
    Tampa, FL (11 mi)

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  • Nebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT Handling

    $37,744

    $993
    54,215 mi.
    Est. $692/mo

    Brandon Hyundai

    4.4
    Check Availability
    Tampa, FL (4 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $40,727

    27,170 mi.
    Est. $746/mo

    Elder Ford of Tampa

    4.3
    Check Availability
    Tampa, FL (11 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $35,299

    $357
    49,554 mi.
    Est. $647/mo

    AutoLenders Palm Harbor

    4.8
    Check Availability
    Palm Harbor, FL (28 mi)
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  • Gray 2022 Lexus RX 350 BaseGray 2022 Lexus RX 350 BaseGray 2022 Lexus RX 350 BaseGray 2022 Lexus RX 350 BaseGray 2022 Lexus RX 350 BaseGray 2022 Lexus RX 350 Base

    $36,597

    $204
    42,215 mi.
    Est. $671/mo

    Brandon Honda

    4.6
    Check Availability
    Tampa, FL (4 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $34,536

    69,373 mi.
    Est. $633/mo

    Gettel Stadium Toyota

    4.4
    Check Availability
    Tampa, FL (13 mi)
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  • $31,998

    116,884 mi.
    Est. $586/mo

    Courtesy Nissan of Tampa

    4.5
    Check Availability
    Tampa, FL (13 mi)
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  • Caviar 2022 Lexus RX 350 Base

    $45,920

    $9.8K
    29,513 mi.
    Est. $842/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (13 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 Premium

    $38,999

    58,852 mi.
    Est. $715/mo

    Lexus of Wesley Chapel

    4.9
    Check Availability
    Wesley Chapel, FL (18 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 Base

    $42,998

    26,903 mi.
    Est. $788/mo

    Lexus of Clearwater

    4.8
    Check Availability
    Clearwater, FL (27 mi)
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  • White 2022 Lexus RX 350 L LuxuryWhite 2022 Lexus RX 350 L LuxuryWhite 2022 Lexus RX 350 L LuxuryWhite 2022 Lexus RX 350 L LuxuryWhite 2022 Lexus RX 350 L LuxuryWhite 2022 Lexus RX 350 L Luxury

    $44,998

    43,944 mi.
    Est. $825/mo

    CarMax Gainesville

    Check Availability
    Free delivery to Tampa, FL (12 mi)
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  • Caviar 2022 Lexus RX 350 F SPORT AppearanceCaviar 2022 Lexus RX 350 F SPORT AppearanceCaviar 2022 Lexus RX 350 F SPORT AppearanceCaviar 2022 Lexus RX 350 F SPORT AppearanceCaviar 2022 Lexus RX 350 F SPORT AppearanceCaviar 2022 Lexus RX 350 F SPORT Appearance

    $31,699

    96,641 mi.
    Est. $581/mo

    Florida Fine Cars WPB

    4.8
    Check Availability
    $250 delivery from West Palm Beach, FL (162 mi)
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  • Grecian Water 2022 Lexus RX 350 BaseGrecian Water 2022 Lexus RX 350 BaseGrecian Water 2022 Lexus RX 350 BaseGrecian Water 2022 Lexus RX 350 BaseGrecian Water 2022 Lexus RX 350 BaseGrecian Water 2022 Lexus RX 350 Base

    $38,420

    35,426 mi.
    Est. $704/mo

    Cox Mazda

    4.7
    Check Availability
    Bradenton, FL (40 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $37,998

    $503
    48,725 mi.
    Est. $696/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (50 mi)
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  • Silver 2022 Lexus RX 350 BaseSilver 2022 Lexus RX 350 BaseSilver 2022 Lexus RX 350 BaseSilver 2022 Lexus RX 350 BaseSilver 2022 Lexus RX 350 BaseSilver 2022 Lexus RX 350 Base

    $38,990

    45,936 mi.
    Est. $715/mo

    Jenkins Hyundai of Leesburg

    4.6
    Check Availability
    Leesburg, FL (67 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $36,596

    54,256 mi.
    Est. $671/mo

    Coast Mazda Port Richey

    4.6
    Check Availability
    Port Richey, FL (34 mi)
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  • Red 2022 Lexus RX 350 F SPORT HandlingRed 2022 Lexus RX 350 F SPORT HandlingRed 2022 Lexus RX 350 F SPORT HandlingRed 2022 Lexus RX 350 F SPORT HandlingRed 2022 Lexus RX 350 F SPORT HandlingRed 2022 Lexus RX 350 F SPORT Handling

    $39,500

    $499
    56,705 mi.
    Est. $724/mo

    Hyundai of Central Florida

    4.8
    Check Availability
    Clermont, FL (56 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $35,003

    33,786 mi.
    Est. $642/mo

    Venice Toyota

    4.3
    Check Availability
    Venice, FL (62 mi)
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  • Gold 2022 Lexus RX 350Gold 2022 Lexus RX 350Gold 2022 Lexus RX 350Gold 2022 Lexus RX 350Gold 2022 Lexus RX 350Gold 2022 Lexus RX 350

    $38,998

    27,646 mi.
    Est. $715/mo

    CarMax Orlando

    Check Availability
    Orlando, FL (70 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $33,983

    $969
    58,424 mi.
    Est. $623/mo

    BMW of Sarasota

    4.7
    Check Availability
    Sarasota, FL (50 mi)
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  • Matador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT Handling

    $40,985

    28,712 mi.
    Est. $751/mo

    Jarrett Ford of Charlotte County

    4.6
    Check Availability
    Port Charlotte, FL (70 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $39,999

    $1.3K
    35,638 mi.
    Est. $733/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (50 mi)
    Quick view
  • White 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 BaseWhite 2022 Lexus RX 350 Base

    $47,000

    24,515 mi.
    Est. $861/mo

    Private seller: John

    Contact Seller
    Okahumpka, FL (59 mi)
    Quick view
  • Atomic Silver 2022 Lexus RX 350 Base

    $34,884

    60,053 mi.
    Est. $639/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (50 mi)
    Quick view

Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $62,401
2025 Lexus RX 350 $52,965 4 Good deals
2024 Lexus RX 350 $48,507 10 Good deals
2023 Lexus RX 350 $46,612 5 Good deals
2020 Lexus RX 350 $31,386 6 Good deals

About the 2022 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350
FAQs

How much does the 2022 Lexus RX 350 cost?

The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $39,956, with pricing starting at $27,450.

What is the MPG of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 compares to and/or competes against the following vehicles:


Is the 2022 Lexus RX 350 reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Is the 2022 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.

(13 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $49,400 Starting at $50,800
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling FWD RX 350 F SPORT Handling AWD
Inventory price
Starting at $51,800 Starting at $53,200
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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