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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $37,112

    $599
    40,732 mi.
    Est. $674/mo

    Honda of Fort Myers

    4.2
    Check Availability
    Fort Myers, FL (12 mi)

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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $37,112

    $599
    40,732 mi.
    Est. $674/mo

    Honda of Fort Myers

    4.2
    Check Availability
    Fort Myers, FL (12 mi)

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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $44,378

    $620
    16,555 mi.
    Est. $806/mo

    Germain Lexus of Naples

    4.9
    Check Availability
    Naples, FL (27 mi)
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  • Matador Red Mica 2022 Lexus RX 350 BaseMatador Red Mica 2022 Lexus RX 350 BaseMatador Red Mica 2022 Lexus RX 350 BaseMatador Red Mica 2022 Lexus RX 350 BaseMatador Red Mica 2022 Lexus RX 350 BaseMatador Red Mica 2022 Lexus RX 350 Base

    $46,494

    18,701 mi.
    Est. $844/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (12 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $37,882

    $750
    33,039 mi.
    Est. $688/mo

    Mercedes-Benz of Bonita Springs

    4.9
    Check Availability
    Bonita Springs, FL (26 mi)
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  • Atomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT Handling

    $44,994

    $600
    63,268 mi.
    Est. $817/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (12 mi)
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  • Matador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT Handling

    $41,245

    28,712 mi.
    Est. $749/mo

    Jarrett Ford of Charlotte County

    4.6
    Check Availability
    Port Charlotte, FL (26 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $36,994

    $1.5K
    50,028 mi.
    Est. $672/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (12 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $44,994

    $1K
    17,714 mi.
    Est. $817/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (12 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $42,888

    17,657 mi.
    Est. $779/mo

    Germain Lexus of Naples

    4.9
    Check Availability
    Naples, FL (27 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 Base

    $46,994

    24,400 mi.
    Est. $853/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (12 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 Base

    $44,994

    18,806 mi.
    Est. $817/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (12 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $44,995

    29,438 mi.
    Est. $817/mo

    Lexus of Palm Beach

    4.8
    Check Availability
    Free delivery from West Palm Beach, FL (117 mi)
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  • Blue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 L

    $40,998

    36,761 mi.
    Est. $744/mo

    CarMax Miami (International Mall)

    Check Availability
    Free delivery to Fort Myers, FL (11 mi)
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  • Mica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 Base

    $31,072

    $479
    116,884 mi.
    Est. $564/mo

    Courtesy Nissan of Tampa

    4.6
    Check Availability
    Tampa, FL (100 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $42,996

    $2.9K
    29,513 mi.
    Est. $781/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (100 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $37,811

    33,916 mi.
    Est. $687/mo

    Naples Chrysler Dodge Jeep Ram

    4.5
    Check Availability
    Naples, FL (32 mi)
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  • Atomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT Handling

    $40,999

    45,743 mi.
    Est. $744/mo

    Dyer Chevrolet

    2.9
    Check Availability
    Lake Wales, FL (94 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $33,799

    $556
    69,373 mi.
    Est. $614/mo

    Gettel Stadium Toyota

    4.4
    Check Availability
    Tampa, FL (100 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT Handling

    $37,054

    $599
    54,215 mi.
    Est. $673/mo

    Brandon Hyundai

    4.4
    Check Availability
    Tampa, FL (94 mi)
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  • Not Priced

    50,179 mi.

    Porsche Naples

    4.9
    Check Availability
    Naples, FL (38 mi)
    Quick view

Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $60,415 1 Good deal
2025 Lexus RX 350 $55,660 5 Great deals
2023 Lexus RX 350 $48,468 10 Good deals

About the 2022 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350
FAQs

How much does the 2022 Lexus RX 350 cost?

The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $40,584, with pricing starting at $27,450.

What is the MPG of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 compares to and/or competes against the following vehicles:


Is the 2022 Lexus RX 350 reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Is the 2022 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.

(13 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $49,400 Starting at $50,800
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling FWD RX 350 F SPORT Handling AWD
Inventory price
Starting at $51,800 Starting at $53,200
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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