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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $43,872

    42,904 mi.
    Est. $806/mo

    Lexus Of Orland

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    Orland Park, IL (21 mi)

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  • Atomic 2022 Lexus RX 350 BaseAtomic 2022 Lexus RX 350 BaseAtomic 2022 Lexus RX 350 BaseAtomic 2022 Lexus RX 350 BaseAtomic 2022 Lexus RX 350 BaseAtomic 2022 Lexus RX 350 Base

    $45,995

    58,043 mi.
    Est. $845/mo

    Woodfield Lexus

    4.8
    Check Availability
    Schaumburg, IL (21 mi)
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  • Nightfall Mica 2022 Lexus RX 350 F SPORT HandlingNightfall Mica 2022 Lexus RX 350 F SPORT HandlingNightfall Mica 2022 Lexus RX 350 F SPORT HandlingNightfall Mica 2022 Lexus RX 350 F SPORT HandlingNightfall Mica 2022 Lexus RX 350 F SPORT HandlingNightfall Mica 2022 Lexus RX 350 F SPORT Handling

    $41,799

    $200
    54,271 mi.
    Est. $768/mo

    McGrath Acura of Morton Grove

    4.4
    Check Availability
    Morton Grove, IL (27 mi)
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  • White 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT Appearance

    $34,950

    72,290 mi.
    Est. $642/mo

    Carbox

    5.0
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    Oakbrook Terrace, IL (12 mi)
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  • Atomic Silver 2022 Lexus RX 350 F SPORT AppearanceAtomic Silver 2022 Lexus RX 350 F SPORT AppearanceAtomic Silver 2022 Lexus RX 350 F SPORT AppearanceAtomic Silver 2022 Lexus RX 350 F SPORT AppearanceAtomic Silver 2022 Lexus RX 350 F SPORT AppearanceAtomic Silver 2022 Lexus RX 350 F SPORT Appearance

    $42,500

    41,789 mi.
    Est. $781/mo

    Motor Werks Cadillac

    4.8
    Check Availability
    Barrington, IL (28 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT Handling

    $44,500

    22,489 mi.
    Est. $817/mo

    Heritage Cadillac

    3.8
    Check Availability
    Lombard, IL (10 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $42,992

    45,499 mi.
    Est. $790/mo

    Rod Baker Ford

    4.6
    Check Availability
    Plainfield, IL (13 mi)
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  • $43,573

    40,949 mi.
    Est. $800/mo

    Lexus Of Orland

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    Orland Park, IL (21 mi)
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  • Black 2022 Lexus RX 350 F-SportBlack 2022 Lexus RX 350 F-SportBlack 2022 Lexus RX 350 F-SportBlack 2022 Lexus RX 350 F-SportBlack 2022 Lexus RX 350 F-SportBlack 2022 Lexus RX 350 F-Sport

    $42,998

    49,494 mi.
    Est. $790/mo

    CarMax Omaha

    4.6
    Check Availability
    $149 delivery to Naperville, IL (5 mi)
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  • Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350

    $33,998

    77,632 mi.
    Est. $625/mo

    CarMax Germantown

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    $199 delivery to Naperville, IL (5 mi)
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  • Cloudburst Gray 2022 Lexus RX 350 BaseCloudburst Gray 2022 Lexus RX 350 BaseCloudburst Gray 2022 Lexus RX 350 BaseCloudburst Gray 2022 Lexus RX 350 BaseCloudburst Gray 2022 Lexus RX 350 BaseCloudburst Gray 2022 Lexus RX 350 Base

    $39,990

    46,143 mi.
    Est. $735/mo

    McGrath Acura of Libertyville

    4.4
    Check Availability
    Libertyville, IL (36 mi)
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  • Blue 2022 Lexus RX 350 F SPORT HandlingBlue 2022 Lexus RX 350 F SPORT HandlingBlue 2022 Lexus RX 350 F SPORT HandlingBlue 2022 Lexus RX 350 F SPORT HandlingBlue 2022 Lexus RX 350 F SPORT HandlingBlue 2022 Lexus RX 350 F SPORT Handling

    $41,977

    29,157 mi.
    Est. $771/mo

    Kunes Lakes Chevrolet‎

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    Lake Bluff, IL (38 mi)
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  • Nightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 Base

    $43,687

    18,155 mi.
    Est. $803/mo

    The Audi Exchange Highland Park

    4.9
    Check Availability
    Highland Park, IL (35 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $38,300

    41,325 mi.
    Est. $704/mo

    Team Toyota

    4.8
    Check Availability
    Schererville, IN (39 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $63,262 1 Good deal
2025 Lexus RX 350 $58,479 12 Good deals
2024 Lexus RX 350 $53,289 22 Good deals
2023 Lexus RX 350 $48,658 20 Good deals
2017 Lexus RX 350 $23,935 10 Good deals
2016 Lexus RX 350 $23,921 3 Good deals

About the 2022 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350
FAQs

How much does the 2022 Lexus RX 350 cost?

The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $39,622, with pricing starting at $5,501.

What is the MPG of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 compares to and/or competes against the following vehicles:


Is the 2022 Lexus RX 350 reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Is the 2022 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.

(13 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $49,400 Starting at $50,800
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling FWD RX 350 F SPORT Handling AWD
Inventory price
Starting at $51,800 Starting at $53,200
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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