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  • Black 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATIC

    $60,993

    $402
    34,350 mi.
    Est. $1,141/mo

    McGrath Acura of Westmont

    4.8
    Check Availability
    Westmont, IL (12 mi)

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  • Black 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATIC

    $61,999

    50,022 mi.
    Est. $1,160/mo

    Mercedes-Benz of Hoffman Estates

    4.7
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    Hoffman Estates, IL (28 mi)
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  • Obsidian Black Metallic 2021 Mercedes-Benz S-Class S 580 4MATICObsidian Black Metallic 2021 Mercedes-Benz S-Class S 580 4MATICObsidian Black Metallic 2021 Mercedes-Benz S-Class S 580 4MATICObsidian Black Metallic 2021 Mercedes-Benz S-Class S 580 4MATICObsidian Black Metallic 2021 Mercedes-Benz S-Class S 580 4MATICObsidian Black Metallic 2021 Mercedes-Benz S-Class S 580 4MATIC

    $61,981

    40,333 mi.
    Est. $1,160/mo

    Star Motor Sales

    4.8
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    Downers Grove, IL (15 mi)
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  • designo Diamond White Metallic 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz S-Class S 580 4MATIC

    $54,995

    60,682 mi.
    Est. $1,029/mo

    Motor Cars Mitsubishi

    4.3
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    Aurora, IL (24 mi)
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  • Graphite Grey Metallic 2021 Mercedes-Benz S-ClassGraphite Grey Metallic 2021 Mercedes-Benz S-ClassGraphite Grey Metallic 2021 Mercedes-Benz S-Class

    $60,948

    $840
    43,875 mi.
    Est. $1,140/mo

    Loeber Motors Mercedes-Benz

    Lincolnwood, IL (19 mi)
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  • Black 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATIC

    $53,995

    $1K
    55,273 mi.
    Est. $1,010/mo

    Baha Auto Sales

    2.8
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    Chicago, IL (12 mi)
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  • Graphite Gray 2021 Mercedes-Benz S-Class S 580 4MATIC

    $59,971

    $410
    38,910 mi.
    Est. $1,122/mo

    Advantage Cadillac

    4.9
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    Hodgkins, IL (6 mi)
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  • designo Diamond White 2021 Mercedes-Benz S-Class S 580 4MATIC

    Not Priced

    0 mi.
    Est. $0/mo

    EMH Motors

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    Arlington Heights, IL (30 mi)
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  • Black 2021 Mercedes-Benz S-ClassBlack 2021 Mercedes-Benz S-ClassBlack 2021 Mercedes-Benz S-ClassBlack 2021 Mercedes-Benz S-ClassBlack 2021 Mercedes-Benz S-ClassBlack 2021 Mercedes-Benz S-Class

    $65,998

    34,425 mi.
    Est. $1,235/mo

    CarMax South Boulevard

    Check Availability
    $249 delivery to Oak Lawn, IL (2 mi)
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  • Silver 2021 Mercedes-Benz S-ClassSilver 2021 Mercedes-Benz S-ClassSilver 2021 Mercedes-Benz S-ClassSilver 2021 Mercedes-Benz S-ClassSilver 2021 Mercedes-Benz S-ClassSilver 2021 Mercedes-Benz S-Class

    $67,998

    28,312 mi.
    Est. $1,272/mo

    CarMax Southlake

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    $399 delivery to Oak Lawn, IL (2 mi)
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  • Rubellite Red 2021 Mercedes-Benz S-Class S 580 4MATICRubellite Red 2021 Mercedes-Benz S-Class S 580 4MATICRubellite Red 2021 Mercedes-Benz S-Class S 580 4MATICRubellite Red 2021 Mercedes-Benz S-Class S 580 4MATICRubellite Red 2021 Mercedes-Benz S-Class S 580 4MATICRubellite Red 2021 Mercedes-Benz S-Class S 580 4MATIC

    $64,200

    26,762 mi.
    Est. $1,201/mo

    Performance Lexus

    4.8
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    Cincinnati, OH (249 mi)
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  • designo Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATIC

    $56,500

    17,509 mi.
    Est. $1,057/mo

    Price Pro

    3.5
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    Maumee, OH (212 mi)
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  • Black 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATICBlack 2021 Mercedes-Benz S-Class S 580 4MATIC

    $59,995

    42,364 mi.
    Est. $1,123/mo

    DM Motors LLC

    2.4
    Check Availability
    Walled Lake, MI (228 mi)
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  • Pearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATIC

    $54,999

    24,228 mi.
    Est. $1,029/mo

    L.A. Trading Co

    Check Availability
    Woodhaven, MI (236 mi)
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  • 2021 Mercedes-Benz S-Class S 580 4MATIC

    $59,995

    43,886 mi.
    Est. $1,123/mo

    Cadillac of Novi

    3.9
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    Novi, MI (227 mi)
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Mercedes-Benz S-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz S-Class $143,973 1 Good deal
2024 Mercedes-Benz S-Class $94,735 7 Good deals
2023 Mercedes-Benz S-Class $83,246 9 Great deals
2022 Mercedes-Benz S-Class $66,680 9 Good deals
2018 Mercedes-Benz S-Class $33,433 7 Good deals

About the 2021 Mercedes-Benz S-Class

Basics

S 500 4MATIC shown (base trim).

Seating
5
Door count
4
Drivetrain
All-wheel Drive
Combined MPG
24
Transmission
9-Speed A/T
Engine
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2021 Mercedes-Benz S-Class
FAQs

How much does the 2021 Mercedes-Benz S-Class cost?

The 2021 Mercedes-Benz S-Class price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 S-Class is $60,054, with pricing starting at $45,595.

What is the MPG of the 2021 Mercedes-Benz S-Class?

The 2021 Mercedes-Benz S-Class offers up to 20 MPG in city driving and 29 MPG on the highway for a combined rating of 24 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz S-Class?

The 2021 Mercedes-Benz S-Class compares to and/or competes against the following vehicles:


Is the 2021 Mercedes-Benz S-Class reliable?

The 2021 Mercedes-Benz S-Class has an average reliability rating of 5 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 S-Class owners.

Is the 2021 Mercedes-Benz S-Class a good sedan?

Below are the Cars.com consumer ratings for the 2021 Mercedes-Benz S-Class.

(4 reviews)
Rating breakdown (out of 5):
Comfort
5.0
Interior
5.0
Performance
5.0
Value
4.8
Exterior
5.0
Reliability
5.0
Ratings (4 reviews)

100% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
5.0
Interior
5.0
Performance
5.0
Value
4.8
Exterior
5.0
Reliability
5.0
Trims

S 500 (1 style)

Style
S 500 4MATIC Sedan
Inventory price
Starting at $109,800
Combined MPG
24
Engine
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)

S 560 (2 styles)

Style
S 560 Cabriolet S 560 4MATIC Coupe
Inventory price
Starting at $140,000 Starting at $131,400
Combined MPG
20 20
Engine
463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel) 463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel)

S 580 (1 style)

Style
S 580 4MATIC Sedan
Inventory price
Starting at $116,300
Combined MPG
20
Engine
496.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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