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  • designo Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATIC

    $62,495

    11,148 mi.
    Est. $1,129/mo

    Road Runner Auto Sales

    3.2
    Check Availability
    Wayne, MI (30 mi)
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  • designo Diamond Whit 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond Whit 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond Whit 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond Whit 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond Whit 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond Whit 2021 Mercedes-Benz S-Class S 580 4MATIC

    $53,988

    70,300 mi.
    Est. $976/mo

    Kian Motors

    3.7
    Check Availability
    $1,247 delivery from Plano, TX (998 mi)
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  • Black 2021 Mercedes-Benz S-Class S 580 4MATIC

    $56,488

    $1.5K
    43,192 mi.
    Est. $1,021/mo

    Kian Motors

    3.7
    Check Availability
    $1,247 delivery from Plano, TX (998 mi)
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  • designo Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATICdesigno Diamond White 2021 Mercedes-Benz S-Class S 580 4MATIC

    $56,500

    17,509 mi.
    Est. $1,021/mo

    Price Pro

    3.5
    Check Availability
    Maumee, OH (81 mi)
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  • Mojave Silver Metallic 2021 Mercedes-Benz S-Class S 580Mojave Silver Metallic 2021 Mercedes-Benz S-Class S 580Mojave Silver Metallic 2021 Mercedes-Benz S-Class S 580Mojave Silver Metallic 2021 Mercedes-Benz S-Class S 580Mojave Silver Metallic 2021 Mercedes-Benz S-Class S 580Mojave Silver Metallic 2021 Mercedes-Benz S-Class S 580

    $58,749

    $151
    33,799 mi.
    Est. $1,062/mo

    BMW of Westlake

    4.8
    Check Availability
    Westlake, OH (105 mi)
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  • Pearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATICPearl White 2021 Mercedes-Benz S-Class S 580 4MATIC

    $54,999

    24,228 mi.
    Est. $994/mo

    L.A. Trading Co

    Check Availability
    Woodhaven, MI (37 mi)
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About the 2021 Mercedes-Benz S-Class

Basics

S 500 4MATIC shown (base trim).

Seating
5
Door count
4
Drivetrain
All-wheel Drive
Combined MPG
24
Transmission
9-Speed A/T
Engine
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2021 Mercedes-Benz S-Class
FAQs

How much does the 2021 Mercedes-Benz S-Class cost?

The 2021 Mercedes-Benz S-Class price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 S-Class is $59,356, with pricing starting at $45,795.

What is the MPG of the 2021 Mercedes-Benz S-Class?

The 2021 Mercedes-Benz S-Class offers up to 20 MPG in city driving and 29 MPG on the highway for a combined rating of 24 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz S-Class?

The 2021 Mercedes-Benz S-Class compares to and/or competes against the following vehicles:


Is the 2021 Mercedes-Benz S-Class reliable?

The 2021 Mercedes-Benz S-Class has an average reliability rating of 5 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 S-Class owners.

Is the 2021 Mercedes-Benz S-Class a good sedan?

Below are the Cars.com consumer ratings for the 2021 Mercedes-Benz S-Class.

(4 reviews)
Rating breakdown (out of 5):
Comfort
5.0
Interior
5.0
Performance
5.0
Value
4.8
Exterior
5.0
Reliability
5.0
Ratings (4 reviews)

100% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
5.0
Interior
5.0
Performance
5.0
Value
4.8
Exterior
5.0
Reliability
5.0
Trims

S 500 (1 style)

Style
S 500 4MATIC Sedan
Inventory price
Starting at $109,800
Combined MPG
24
Engine
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)

S 560 (2 styles)

Style
S 560 Cabriolet S 560 4MATIC Coupe
Inventory price
Starting at $140,000 Starting at $131,400
Combined MPG
20 20
Engine
463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel) 463.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline Fuel)

S 580 (1 style)

Style
S 580 4MATIC Sedan
Inventory price
Starting at $116,300
Combined MPG
20
Engine
496.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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