2021
GMC Sierra 2500

Starts at:
$45,600
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New 2021 GMC Sierra 2500
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Available trims

See the differences side-by-side to compare trims.
  • 2WD Reg Cab 142"
    Starts at
    $36,200
    3
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,976 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 2WD Double Cab 149"
    Starts at
    $38,800
    6
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,811 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Reg Cab 142"
    Starts at
    $39,000
    3
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    4,013 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 2WD Double Cab 162"
    Starts at
    $39,000
    6
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,840 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 2WD Crew Cab 159"
    Starts at
    $40,600
    6
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,798 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 2WD Crew Cab 172"
    Starts at
    $40,800
    6
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,848 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 2WD Reg Cab 142" SLE
    Starts at
    $41,600
    3
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,976 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Double Cab 149"
    Starts at
    $41,600
    6
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    3,795 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Double Cab 162"
    Starts at
    $41,800
    6
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    3,851 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 159"
    Starts at
    $43,400
    6
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    3,808 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 2WD Double Cab 149" SLE
    Starts at
    $43,600
    5
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,811 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 172"
    Starts at
    $43,600
    6
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    3,909 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 2WD Double Cab 162" SLE
    Starts at
    $43,800
    5
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,840 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Reg Cab 142" SLE
    Starts at
    $44,400
    3
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    4,013 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 2WD Crew Cab 159" SLE
    Starts at
    $45,400
    5
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,798 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 2WD Crew Cab 172" SLE
    Starts at
    $45,600
    5
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,848 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 4WD Double Cab 149" SLE
    Starts at
    $46,400
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    3,795 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Double Cab 162" SLE
    Starts at
    $46,600
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    3,851 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 159" SLE
    Starts at
    $48,200
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    3,808 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 172" SLE
    Starts at
    $48,400
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    3,909 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 2WD Double Cab 149" SLT
    Starts at
    $51,600
    5
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    4,011 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 2WD Double Cab 162" SLT
    Starts at
    $51,800
    5
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    4,040 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 2WD Crew Cab 159" SLT
    Starts at
    $53,400
    5
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    3,998 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 2WD Crew Cab 172" SLT
    Starts at
    $53,600
    5
    Seat capacity
    Gas V8
    Engine
    Rear Wheel Drive
    Drivetrain
    4,048 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 4WD Double Cab 149" SLT
    Starts at
    $54,400
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    3,995 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Double Cab 162" SLT
    Starts at
    $54,600
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    4,101 lbs
    Payload Capacity
    14,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 159" SLT
    Starts at
    $56,200
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    4,008 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 172" SLT
    Starts at
    $56,400
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    4,109 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 159" AT4
    Starts at
    $59,100
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    4,008 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 172" AT4
    Starts at
    $59,300
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    4,109 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 159" Denali
    Starts at
    $65,500
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    4,008 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs
  • 4WD Crew Cab 172" Denali
    Starts at
    $65,700
    5
    Seat capacity
    Gas V8
    Engine
    Four Wheel Drive
    Drivetrain
    4,109 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    See all specs

Photo & video gallery

2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500 2021 GMC Sierra 2500

The good & the bad

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Available cars near you

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Factory warranties

New car program benefits

Basic
3 years / 36,000 miles
Corrosion
3 years / 36,000 miles
Powertrain
5 years / 60,000 miles
Roadside Assistance
5 years / 60,000 miles

Certified Pre-Owned program benefits

Age / mileage
5 model years or newer / up to 75,000 miles
Basic
12 months / 12,000 miles bumper-to-bumper original warranty, then may continue to 6 years / 100,000 miles limited (depending on variables)
Dealer certification
172-point inspection
See all CPO program details

Compare similar vehicles

Select cars to compare for more detailed info.
  • 2021
    4.3
    GMC Sierra 2500
    Starts at
    $36,200
    2021 GMC Sierra 2500
    3
    Seat capacity
    Gas V8
    Engine
    Rear-wheel drive
    Drivetrain
    3,848 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
    Compare
  • 2023
    GMC Sierra 2500
    Starts at
    $42,200
    2023 GMC Sierra 2500
    3
    Seat capacity
    Gas V8
    Engine
    Rear-wheel drive
    Drivetrain
    3,993 lbs
    Payload Capacity
    18,500 lbs
    Towing Capacity
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  • 2020
    4.9
    GMC Sierra 3500
    Starts at
    $37,000
    2020 GMC Sierra 3500
    2
    Seat capacity
    Gas V8
    Engine
    Rear-wheel drive
    Drivetrain
    4,328 lbs
    Payload Capacity
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  • 2024
    4.5
    Chevrolet Silverado 2500
    Starts at
    $44,400
    2024 Chevrolet Silverado 2500
    3
    Seat capacity
    Gas V8
    Engine
    Rear-wheel drive
    Drivetrain
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Consumer reviews

78% of drivers recommend this car
4.3 / 5
Based on 28 reviews
Write a review
Comfort 4.8
Interior 4.6
Performance 4.4
Value 4.0
Exterior 4.6
Reliability 4.1

Most recent

  • By Kendall from Searcy, AR
    Owns this car
    February 22, 2025

    This thing has been a nightmare since we bought it.

    This thing has been a nightmare since we bought it. We purchased it used in 24 with 100k miles. A few months later it blew a head gasket and had to have a new engine put in. Since then it's been chasing down intermittent, random check engine codes and losing coolant to which we can't find the source of. The multipro tailgate is a pain and only works half the time. Sometimes the radio freezes. "Service steering column lock" message intermittently. Clunking shifting and hesitation around 55mph. It goes on and on. Between our own pocket book and the extended warranty, over $30,000 has been spent in repairs. Yes, you read that right, 30k. Biggest piece of garbage ever.
    • Purchased a Used car
    • Used for Transporting family
    • Does not recommend this car
    Comfort 5.0
    Interior 5.0
    Performance 3.0
    Value 1.0
    Exterior 5.0
    Reliability 1.0
    1 person out of 2 found this review helpful. Did you?
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  • By T Jones from Oakland Ca
    Owns this car
    October 24, 2023

    Beautiful truck

    I love my 2021 GMC Denali 2500HD. I have gotten more complements on this truck than any other vehicle that I have owned. I get great highway fuel milage average 19-26mpg,which is great for a heavy duty truck!
    • Purchased a New car
    • Used for Having fun
    • Does recommend this car
    Comfort 4.0
    Interior 4.0
    Performance 5.0
    Value 5.0
    Exterior 5.0
    Reliability 5.0
    2 people out of 3 found this review helpful. Did you?
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  • By David Cunningham from Virgina Beach Virginia
    Owns this car
    September 17, 2023

    Best truck I ever owned

    Love my GMC. Owned a Chevy and this absolutely beats it hands down. Never had any issues. Inside is very comfortable and can't imagine driving anything else
    • Purchased a Used car
    • Used for Commuting
    • Does recommend this car
    Comfort 5.0
    Interior 5.0
    Performance 5.0
    Value 5.0
    Exterior 5.0
    Reliability 5.0
    0 people out of 0 found this review helpful. Did you?
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  • By Travel gal from Phoenix, AZ
    Owns this car
    August 12, 2023

    Unreliable mechanical and technical nightmare!

    First GMC, last GMC. Buyers, run in the other direction from the 2021 GMC Sierra 2500HD Denali, or live with daily, expensive regret! This is the worst and most unreliable vehicle I have ever purchased (new), and I have had many new and used. Steer clear of this year, make, and model! Expect mechanical failures, issues and annoyances you will never get resolved despite numerous trips for diagnostics and repairs, even if the issues are known and popularized. And expect to have your vehicle in the shop for weeks-months annually for unsuccessful diagnoses. And good luck with getting quality dealership service, even if taken out of state to give other locations a chance. This truck has persistent ac and defrost issues over 1500 rpm from day 1 with no resolution, makes desert summers and any winter driving miserable. Your only saving graces are keeping towels on hand to “defrost”, and cooled front seats for hot days - when they work! So expect to drive under the speed limit or without pushing the truck too much on inclines if you want to have ac/defrost conveniences. Multiple sensor failures/errors - too many to mention. Recurring blown fuses and issues with trailering system - as in several times per month - dealerships “see the messages but can’t find a problem. Recommendations made - keep boxes of fuses on hand at all times. Repeat issues with braking system, even after service bulletin repair - brakes are slow to respond and most embarrassing squeaking ever heard. Also receive constant messages that “new brake pads are found”, with info screen saying there is 0 front brake pad life. One of my other least faves is that the camera system that is played up with the extensive angles is useless for the views you need the most - Misaligned reverse camera - off center, negating use of the camera for hitching. “Split” in camera view that appeared after first service appt to resolve the recurring screen blackout makes using the camera for centering vehicle between parking lines impossible - as you never know if the top part of the screen is accurate or the bottom. Dealership response - “we compared to others, and most have these same issues”. What?! Advisors feel this acceptable, “within spec”?! Zoom in on the photos of this make/model for sale - you will see this in most of them. Shaky steering column during ENTIRETY of every drive and loud rubbing when reversing and turning wheel to back out of spot or do 3 point turn - acknowledged by techs yet they “can’t find the issue”. Ongoing shutter error codes and check engine light - even with a service bulletin, if the light turns off before your appt (which occurs consistently), you are out of luck for repair. Truck chirps when going over bumps which is also embarrassing in parking lots, and it squeaks when you exit the vehicle - yet more anomalies acknowledged by the technicians but root cause/s unable to be identified. And then there is the occasional loud gear grinding when moving to 1st gear, the more often struggle of the transmission into 2nd and 3rd, and the vehicle lurching when trying to maintain slow speed in these gears while towing. The DEF and even fuel level gauges - completely unreliable; have had multiple mishaps at night in the boonies due to this (must keep DEF on hand at all times!). I have 5 roadside assistance packages that I subscribe to; yet none of them will help get this vehicle to a shop when you are stranded more than 10-20 mi away from a GMC dealership. So expect to pay much and often for your per mile towing rate for truck breakdowns. I could literally go on and on about the MOST stressful purchase I have ever made. You will find 95%+ of your issues either “cannot be reproduced” during your service appointments, are “within spec”, “can’t be figured out”, or “due to something different than your last visit” - in other words, this is how the game is played to disqualify the vehicle as an official lemon for lemon law purposes.
    • Purchased a New car
    • Used for Commuting
    • Does not recommend this car
    Comfort 5.0
    Interior 5.0
    Performance 2.0
    Value 1.0
    Exterior 5.0
    Reliability 1.0
    12 people out of 16 found this review helpful. Did you?
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  • By Brad S. from Troup TX
    Owns this car
    March 28, 2022

    Consider with caution

    I have had my 2021 Sierra 2500HD Diesel Denali for less than a year now. I bought it because we are fulltime RV'ers hauling a 35' 5th wheel. The power is fantastic and feels like we're hauling nothing, even in the NC mountains. The looks inside and out are great as well. I love this truck...WHEN IT WORKS. I have had to have this truck serviced quite a few times already. The issues I have experienced so far are the camera system keeps going out randomly. Dealership says a software update was needed to fix it and completed. However the issue continues to occur. The stereo will go out randomly as well. Last occurrence I could not change the station or adjust the volume. Same suggested fix; Software update.(In the shop now...again). The DEF fluid gauge is completely unreliable. On multiple occasions the truck will say 200 miles till empty and will decrease power. Problem is that I just pulled away from filling up the DEF. Dealership fix is to use a manufacturer DEF fluid only. Lastly, I used the 4WD high for the very first time last week just to pull out of the muddy yard and get on the driveway. When I attempted to shift back into 2WD I got the dreaded "service 4WD". In the shop now. I can't see a scenario where I would buy this vehicle again with all of the repetitive issues. If you're shopping and considering this vehicle, consider it with extreme caution. This thing is an 80k turd bird.
    • Purchased a New car
    • Used for Commuting
    • Does not recommend this car
    Comfort 4.0
    Interior 4.0
    Performance 3.0
    Value 1.0
    Exterior 5.0
    Reliability 1.0
    29 people out of 30 found this review helpful. Did you?
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  • By AT4Me from Lake Arrowhead, CA
    Owns this car
    May 26, 2021

    GMC 2500 HD AT4

    This is the first diesel I have owned. The power is amazing and I really like the room inside the cab. This truck is a beast... Love it!
    • Purchased a New car
    • Used for Towing
    • Does recommend this car
    Comfort 5.0
    Interior 5.0
    Performance 5.0
    Value 5.0
    Exterior 5.0
    Reliability 5.0
    4 people out of 4 found this review helpful. Did you?
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  • By Susan L from Hopkinsville
    Test drove this car
    May 19, 2021

    Never had one. Always wanted one and love it.

    I love my Denali. Beautiful truck inside out. When I drive down the road all heads turn. I couldn't have made a better choice. That's Cortez for you good service.
    • Purchased a Used car
    • Used for Commuting
    • Does recommend this car
    Comfort 5.0
    Interior 5.0
    Performance 5.0
    Value 5.0
    Exterior 5.0
    1 person out of 1 found this review helpful. Did you?
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  • By TARD from Warwick NY
    Owns this car
    May 18, 2021

    Early to tell truck has less than 100 miles

    Truck was bought specifically to our travel trailer. We have to wait for 1000 break in before we can tow the trailer. So far the truck is very quiet, smooth running, & comfortable to drive. We were pleasantly surprised at how much interior storage space is available. Having the bed steps before rear tires and in the bumper sides is very nice. Bed rails are even with my shoulders so the steps get used a lot.
    • Purchased a New car
    • Used for Towing
    • Does recommend this car
    Comfort 5.0
    Interior 5.0
    Performance 4.0
    Value 5.0
    Exterior 5.0
    Reliability 4.0
    0 people out of 1 found this review helpful. Did you?
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  • By MJR from Jacksonville, FL
    Owns this car
    May 6, 2021

    Great Truck

    First diesel, excellent fuel mileage, much more comfortable and roomy compared to my previous 2016 GMC 2500 New mirror location does pose issue with seeing people or cars (blind spot) Overall extremely pleased
    • Purchased a New car
    • Used for Towing
    • Does recommend this car
    Comfort 5.0
    Interior 5.0
    Performance 5.0
    Value 4.0
    Exterior 5.0
    Reliability 5.0
    0 people out of 0 found this review helpful. Did you?
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  • By Kstmbuild from Bedford
    Owns this car
    April 26, 2021

    MY second GMC 2500 HD and it won't be my last.

    I just upgraded from my 2016 GMC 2500 to a new 2021 GMC 2500. I really liked my 2016 and had decided it was the best truck I had owned in 40 plus years of owning and driving pickup trucks. I just picked up the 2021 and it is a vast improvement in almost everyway over the 2016. The technology, design and ride of the truck are spot on. The new truck is ultra quiet especially for a diesel. I really liked the slightly smaller overall size of my previous truck but I find myself quickly adjusting to this updated version. I have read reviews by others who alledge that the interior is not up to par against Ford and Ram but I honestly don't feel that way at all. Its hard for me to imagine a better package in a heavy duty pickup. I know from experience that this truck rides better than the other two manufacturers as they still emplay solid front axles as opposted to the GMC independent front suspension.
    • Purchased a New car
    • Used for Towing
    • Does recommend this car
    Comfort 5.0
    Interior 5.0
    Performance 5.0
    Value 5.0
    Exterior 5.0
    Reliability 5.0
    0 people out of 0 found this review helpful. Did you?
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  • By Dooon from Pueblo Colorado
    Owns this car
    April 23, 2021

    Incredible beast of a truck!!!

    2021 GMC 2500 Denali is an exceptional truck. It’s ride is beyond any truck expectations. The auto operating running boards have turned out to be great for getting in and out of this beast of a truck. I got this truck to haul my 5th wheel trailer and it pulls the trailer like it’s not even there. Styling in and out is beautiful but sturdy and unique over its competitors. The info/ 15 camera system is unbelievably helpful especially pulling the trailer. This truck drives and rides better than most luxury sedans but is a beefy do it all truck.
    • Purchased a New car
    • Used for Towing
    • Does recommend this car
    Comfort 5.0
    Interior 5.0
    Performance 5.0
    Value 5.0
    Exterior 5.0
    Reliability 5.0
    1 person out of 1 found this review helpful. Did you?
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  • By Gnitro from LaBelle L
    Owns this car
    April 3, 2021

    No visibility

    Drivers seat is too low. I cannot see over the dash without sitting on pillows. I have never owned a vehicle this bad. So dangerous. We were told that power seats were not available for this model
    • Purchased a New car
    • Used for Commuting
    • Does not recommend this car
    Comfort 4.0
    Interior 4.0
    Performance 4.0
    Value 5.0
    Exterior 4.0
    Reliability 4.0
    1 person out of 4 found this review helpful. Did you?
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GMC dealers near you

See all GMC dealers near you

FAQ

What trim levels are available for the 2021 GMC Sierra 2500?

The 2021 GMC Sierra 2500 is available in 5 trim levels:

  • (10 styles)
  • AT4 (2 styles)
  • Denali (2 styles)
  • SLE (10 styles)
  • SLT (8 styles)

What are some similar vehicles and competitors of the 2021 GMC Sierra 2500?

The 2021 GMC Sierra 2500 compares to and/or competes against the following vehicles:

Is the 2021 GMC Sierra 2500 reliable?

The 2021 GMC Sierra 2500 has an average reliability rating of 4.1 out of 5 according to cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 GMC Sierra 2500 owners.

Is the 2021 GMC Sierra 2500 a good Truck?

Below are the cars.com consumers ratings for the 2021 GMC Sierra 2500. 78.6% of drivers recommend this vehicle.

4.3 / 5
Based on 28 reviews
  • Comfort: 4.8
  • Interior: 4.6
  • Performance: 4.4
  • Value: 4.0
  • Exterior: 4.6
  • Reliability: 4.1

GMC Sierra 2500 history

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