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*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
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Used
2021 Mercedes-Benz E-Class E 450 4MATIC
for sale
near me
- Down Payment
- $0
- Net trade-in value
- $0
- Months
- 72
- APR
- 7.0%
- Sales tax
- 0.0%
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
Mercedes-Benz Certified
2021 Mercedes-Benz E-Class E 450 4MATIC
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I had an incredibly smooth and painless new car leasing
I had an incredibly smooth and painless new car leasing experience yesterday with Trentino Manco and his colleagues at Rallye Motors in Roslyn. I was not surprised – I have purchased and leased my last four cars with Trent’s assistance. He is always professional, helpful, honest, and trustworthy. Trent has made the previously unpleasant car buying/leasing experience a thoroughly enjoyable one. I wholeheartedly and highly recommend contacting Trentino Manco and his team if you are looking for a new Mercedes. You will be in good hands.
Most beautiful car I have ever had
I love my car All the technology on it it’s like a dream Interiores are so beautifully design and comfortable Runs so smooth, I feel like a millionaire driving it🥰
Used
2021 Mercedes-Benz E-Class E 450 4MATIC
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I BOUGHT A MERCEDIES E CLASS USED GOT A GREAT PRICE STAFF
I BOUGHT A MERCEDIES E CLASS USED GOT A GREAT PRICE STAFF WAS GREAT IT HAD 4X4 AND WITHALL THE SNOW THANKS GEORGE
Very nice car so far
Owned for a month so far. Aside from a slight rattle occasionally in the passenger door everything is great. Still on the 1000 mile engine break-in but it is very quick. Gas mileage is running about 20 MPG in town and 29 on the highway. Very comfortable and feels very much like a luxury car. Traded in a 2016 Audi A6 which was also a very good car. The E450 just feels more luxurious and quicker. Slightly better steering feel as well.
Used
2021 Mercedes-Benz E-Class 4MATIC
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Super Satisfied
I recently purchased a truck from SAG Denver, I have had a very positive and professional experience with the sales and service departments. I normally avoid dealerships at all costs, however I came across a beautiful truck that I was having difficulty finding on the private market. I enquired online and was replied to very expediently. I received a no pressure call from a sales person who scheduled an appointment with me. When I arrived, I was greeted and assisted immediately. I test drove the truck with Tracey, who by the way, I highly recommend working with. After driving and inspecting the truck for a bit, I detected what is a common mechanical problem with that type of truck. I brought it up to Tracey and the sales manager Dan and my concerns were immediately acknowledged and validated. Dan did not try to gloss over my concern or argue that there was an issue, instead, he gracefully offered to have the repairs made along with any other contributing or resulting damage as needed. I left the truck with them to begin the repairs, unfortunately it was a bit more involved than originally thought. There ended up being a significant amount of engine work needed, nothing that could have possibly been detectable without opening up the motor. I think most dealerships would have somehow tried to find a way to charge me or unwind the deal rather than proceed with completing all necessary repairs and making the truck run properly. I have several other vehicles so I wasn't by any means inconvenienced, however I did purchase the truck because I had to haul some things for family. After the repairs ran into an extended period of time I did email to express my concerns, I received a call from Dan offering me another truck from their inventory until the repairs were completed on mine. I can't express enough how impressed and pleased I am with the entire experience with Springs Automotive in Denver, I would definitely recommend them and would buy from them again.
One of the best cars I’ve ever owned
The car rides great and looks good. I like the lines and response of the car. Nice color and the features are excellent. I recommend this dealership and car to everyone.
Used
2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain
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After searching for over two weeks, I finally purchased a
After searching for over two weeks, I finally purchased a 2023 Toyota Camry as my first car—and C&K made the process smoother than I ever could have imagined! The team was knowledgeable, transparent, and answered all of my questions without any pressure. Best of all, there were no outrageous or hidden fees. I couldn’t be happier with my experience and would absolutely recommend C&K to anyone looking for a car!
This car is why you buy a Mercedes-Benz.
I'm replacing a 17 y/o E-320 that I loved. I am now infatuated with the New 2021 E-450 4 matic it just so happens to be the Motor Trend car of the year. Very nice exterior styling. Fantastic interior. all the latest technology and a great interior. The strait V-6 with turbo is smooth as silk. The optional Air Body control suspension makes for a fantastic smooth ride.
Used
2021 Mercedes-Benz E-Class
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Good Experience.
Good Experience. Good Service. Helpful Representatives. Able to answer all my questions. Assisted in transferring to Arizona Carmax.
Love my Car
The vehicle meets all of my needs. I special ordered the vehicle with the color and leather interior I prefer. It arrived exactly the way I wanted.
Used
2021 Mercedes-Benz E-Class 4MATIC
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The CarShop employees are the best!
The CarShop employees are the best! Again I needed help right away, this time with a passenger side mirror being almost pulled off. Morgan, the customer service tech & his manager Bill had a mechanic take a look to see what could be done & because the mirror was not totally pulled off & the wires were intact they were able to glue the mirror back onto the mirror perch mount & never even charged me. I will surely use them again. Thank you for your help & kindness CarShop
Used
2021 Mercedes-Benz E-Class 4MATIC
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I had an incredible new car buying experience at Briggs
I had an incredible new car buying experience at Briggs of Fort Scott. I couldn’t find the vehicle I wanted locally, so I traveled 450 miles to Fort Scott, Kansas. The dealership was not “paved with gold tiles” like some of the large dealerships near my home. Instead, I found a small-town dealership offering a golden experience. Even with the travel expenses included, the vehicle was less expensive than it would be if I was able to buy it locally. It was also, by far, the fastest buying process I have ever experienced, from the time I showed up to the time I was driving away with my new car. I had a great experience with the people in both sales and finance. Thank you, Steven, Brad, and Grant, for providing me with incredible service! I strongly recommend Briggs if you live in Kansas or even if you live in another part of the country like me.
Used
2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain
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Car was no longer available but dealer was responsive and
Car was no longer available but dealer was responsive and professional. They always have a great selection of cars.
Used
2021 Mercedes-Benz E-Class 4MATIC
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Best experience I have ever had buying a car.
Best experience I have ever had buying a car. Kriss Stepp was my sales person and he was very knowledgeable and courteous. I will never go any other place.
Used
2021 Mercedes-Benz E-Class 4MATIC
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Jonathan was great thank you for helping me purchase my
Jonathan was great thank you for helping me purchase my Cadillac jeep wrangler you were great
Used
2021 Mercedes-Benz E-Class 4MATIC
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Brought my ‘24 GLE in for a check engine light and a rear
Brought my ‘24 GLE in for a check engine light and a rear window washer blockage. Service tech found exhaust baffle blocked due to icing, heated and greased with great success. Tech also found washer fluid line blocked and frozen. This problem was also corrected. Tech performed a complete vehicle inspection as well. All service work was accomplished with no charge. The dealership also provided me with a brand new 2026 GLC courtesy car for the day. Five Star ⭐️ service including my time spent with Tom O’Connor my service advisor!
Used
2021 Mercedes-Benz E-Class 4MATIC
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Sheri was excellent and accommodating to deal with since
Sheri was excellent and accommodating to deal with since we had an insurance claim to deal with to purchase our next vehicle. I would highly recommend the dealership and asking for her.
Mercedes-Benz Certified
2021 Mercedes-Benz E-Class E 450 4MATIC
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Best car buying experience I’ve ever had.
Best car buying experience I’ve ever had. Freddie was my sales guy and was wonderful
Mercedes-Benz Certified
2021 Mercedes-Benz E-Class 4MATIC
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It was a great experience from beginning to end.
It was a great experience from beginning to end. I got exactly what I wanted and it was delivered to me in perfect condition. I can’t thank them enough.
Used
2021 Mercedes-Benz E-Class 4MATIC
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I really appreciate the friendly and efficient service of
I really appreciate the friendly and efficient service of Sebastian Alexander Mejia, you provide every time with a smile and timely help. Thanks for the excellent service.
Used
2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain
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Service Sch A but hard to tell
Had service A done and tires rotated. Hard to tell if oil was changed without a dip stick to look at and the tires I guess were rotated but hard to tell with the fact the tire pressure was the same in each wheel as before rotation.
Used
2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain
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I recently bought a Tesla from Auto Trade Mark in
I recently bought a Tesla from Auto Trade Mark in Virginia, and the experience was absolutely fantastic. After a terrible encounter with a dealership in Dumfries, working with this family-owned company was a breath of fresh air. They were responsive, honest, and true to their word from start to finish. Even when an issue came up with the car shortly after the purchase, they stood by their contractual obligations and made sure everything was handled professionally. That level of integrity is rare these days. I can’t recommend these guys enough — they really care about their customers and take pride in what they do. If you’re in the market for a great used car and want to be treated right, ask for Farhan — he’s outstanding!
Used
2021 Mercedes-Benz E-Class 4MATIC
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Although my repair took 34 days, it was no fault of
Although my repair took 34 days, it was no fault of Brendan who was accommodating in every way. Parts availability issue... I was given a 2025 Discovery as alternate transportation which I much appreciated. Brendan was super apologetic towards the delay in securing my part. I'm grateful for his working with me to get most of my repair covered under warranty and also working with me on my cost to replace all 4 tires and front brakes. Thank you Brendan! I hope not to see you soon, but if I need to, I look forward to working with you!
Used
2021 Mercedes-Benz E-Class 4MATIC
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I put information about my car into Kelley Bluebook.
I put information about my car into Kelley Bluebook.com. I received an email from Luis at Autonation Ford saying they were interested in the car and explaining how the process works if we sold it to them. We went in and worked with him and sold the car to the dealership. He was friendly, helpful, and knowledgeable. The process went smoothly, just as he had indicated in the email. I appreciated that they didn?t play games and we were pleased with the process. Would recommend.
Used
2021 Mercedes-Benz E-Class 4MATIC
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I had a great experience purchasing my vehicle at Auto
I had a great experience purchasing my vehicle at Auto Giants Mitsubishi. Matt and Joel were professional, knowledgeable, and incredibly helpful throughout the entire process. They took the time to understand what I wanted, worked within my budget, and made sure I was comfortable with every decision. There was zero pressure, clear communication, and full transparency which made the buying process smooth and stress-free. They went above and beyond to get me exactly what I was looking for, and I truly felt supported from start to finish. Everything was handled efficiently, and there were no hidden surprises. I highly recommend Auto Giants Mitsubishi, especially if you’re working with Matt and Joel. This was one of the best car-buying experiences I’ve had.
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Mercedes-Benz E-Class prices by year
| Model year | Average price | Deals |
|---|---|---|
| 2026 Mercedes-Benz E-Class E 450 4MATIC | ||
| 2025 Mercedes-Benz E-Class E 450 4MATIC | $68,911 | 5 Great deals |
| 2024 Mercedes-Benz E-Class E 450 4MATIC | $64,471 | 4 Good deals |
| 2023 Mercedes-Benz E-Class E 450 4MATIC | $47,987 | 33 Great deals |
| 2022 Mercedes-Benz E-Class E 450 4MATIC | $46,342 | 12 Great deals |
| 2020 Mercedes-Benz E-Class E 450 4MATIC | $34,005 | 13 Good deals |
| 2019 Mercedes-Benz E-Class E 450 4MATIC | $29,503 | 7 Great deals |
About the 2021 Mercedes-Benz E-Class E 450 4MATIC
E 450 4MATIC shown.
- Seating
- 5
- Door count
- 4
- Drivetrain
- All Wheel Drive
- Combined MPG
- 26
- Transmission
- 9-Speed A/T
- Engine
- 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
How much does the 2021 Mercedes-Benz E-Class E 450 4MATIC cost?
The 2021 Mercedes-Benz E-Class E 450 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class E 450 4MATIC is $39,495, with pricing starting at $27,900.
What is the MPG of the 2021 Mercedes-Benz E-Class E 450 4MATIC?
The 2021 Mercedes-Benz E-Class E 450 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 26 MPG.
These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.
What are some similar vehicles and competitors of the 2021 Mercedes-Benz E-Class E 450 4MATIC?
The 2021 Mercedes-Benz E-Class E 450 4MATIC compares to and/or competes against the following vehicles:
Is the 2021 Mercedes-Benz E-Class E 450 4MATIC reliable?
The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.
66% of drivers recommend this car
- Comfort 4.6
- Interior 4.4
- Performance 4.3
- Value 4.0
- Exterior 4.4
- Reliability 3.9
E 450 (3 styles)
| Style | ||
|---|---|---|
| E 450 4MATIC Cabriolet | E 450 4MATIC All-Terrain Wagon | E 450 4MATIC Sedan |
| Inventory price | ||
| Starting at $74,450 | Starting at $67,600 | Starting at $62,000 |
| Combined MPG | ||
| 25 | 24 | 26 |
| Engine | ||
| 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) | 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) | 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) |
*Estimated payments are calculated by Cars.com and are for informational purposes only. We’ve estimated your taxes based on your provided ZIP code. These estimates do not include title, registration fees, lien fees, or any other fees that may be imposed by a governmental agency in connection with the sale and financing of the vehicle. Other taxes may apply. They do not represent a financing offer or a guarantee of credit from the seller. Actual terms vary by lender.
**Your Saved Vehicles list will be shared along with your contact information when you submit a vehicle request to a dealership. To opt out of this sharing, please view your options on Cars.com Privacy Notice.
Mercedes-Benz E-Class trims
-
Mercedes-Benz E-Class 2021 E 350
3 Great Deals out of 91 listings starting at $23,495
-
Mercedes-Benz E-Class 2021 E 350 4MATIC
62 listings starting at $20,518
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