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  • Cirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $40,782

    33,138 mi.
    Est. $724/mo

    AutoNation USA Phoenix Avondale

    4.8
    Avondale, AZ (1,462 mi)
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  • MANUFAKTUR Selenite Gray Magno 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Selenite Gray Magno 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Selenite Gray Magno 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Selenite Gray Magno 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Selenite Gray Magno 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Selenite Gray Magno 2022 Mercedes-Benz E-Class E 450

    $37,780

    53,805 mi.
    Est. $671/mo

    Honda of Grand Blanc

    4.7
    Grand Blanc, MI (217 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $41,998

    40,382 mi.
    Est. $746/mo

    CarMax Tucson

    4.8
    Tucson, AZ (1,441 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $55,998

    $1K
    18,470 mi.
    Est. $994/mo

    CarMax Columbus

    Columbus, GA (663 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $57,998

    7,241 mi.
    Est. $1,030/mo

    CarMax Killeen

    4.9
    Killeen, TX (932 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $45,998

    $1K
    13,249 mi.
    Est. $817/mo

    CarMax Gainesville

    Gainesville, FL (893 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $41,998

    42,406 mi.
    Est. $746/mo

    CarMax Savannah

    Savannah, GA (772 mi)
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  • White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $55,634

    14,433 mi.
    Est. $988/mo

    Mercedes-Benz of Creve Coeur

    4.6
    Creve Coeur, MO (267 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $45,913

    $1.2K
    14,150 mi.
    Est. $815/mo

    Euro Motorcars Germantown

    4.0
    Germantown, MD (576 mi)
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  • Rubellite Red Metallic 2022 Mercedes-Benz E-Class E 450Rubellite Red Metallic 2022 Mercedes-Benz E-Class E 450Rubellite Red Metallic 2022 Mercedes-Benz E-Class E 450Rubellite Red Metallic 2022 Mercedes-Benz E-Class E 450Rubellite Red Metallic 2022 Mercedes-Benz E-Class E 450Rubellite Red Metallic 2022 Mercedes-Benz E-Class E 450

    $58,476

    $520
    18,531 mi.
    Est. $1,038/mo

    Mercedes-Benz of Foothill Ranch

    4.8
    Lake Forest, CA (1,725 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450

    $48,274

    29,421 mi.
    Est. $857/mo

    Easterns Automotive Group of West Baltimore

    4.8
    Baltimore, MD (600 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $47,998

    $1K
    8,073 mi.
    Est. $852/mo

    CarMax Town Center

    4.2
    Kennesaw, GA (569 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $41,998

    $1K
    34,160 mi.
    Est. $746/mo

    CarMax Murrieta

    Murrieta, CA (1,705 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $56,998

    $1K
    12,615 mi.
    Est. $1,012/mo

    CarMax Pharr

    4.8
    Pharr, TX (1,238 mi)
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  • Gray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATIC

    $43,990

    47,969 mi.
    Est. $781/mo

    Certified Used Cars by Pollard

    Lubbock, TX (968 mi)
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  • PINK 2022 Mercedes-Benz E-Class E450PINK 2022 Mercedes-Benz E-Class E450PINK 2022 Mercedes-Benz E-Class E450PINK 2022 Mercedes-Benz E-Class E450PINK 2022 Mercedes-Benz E-Class E450PINK 2022 Mercedes-Benz E-Class E450

    $42,900

    $1K
    35,850 mi.
    Est. $762/mo

    PK Motors Group

    Las Vegas, NV (1,517 mi)
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  • Emerald Green Metallic 2022 Mercedes-Benz E-Class 4MATICEmerald Green Metallic 2022 Mercedes-Benz E-Class 4MATICEmerald Green Metallic 2022 Mercedes-Benz E-Class 4MATICEmerald Green Metallic 2022 Mercedes-Benz E-Class 4MATICEmerald Green Metallic 2022 Mercedes-Benz E-Class 4MATICEmerald Green Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $43,480

    33,750 mi.
    Est. $772/mo

    Aston Martin Denver

    Highlands Ranch, CO (923 mi)
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  • White 2022 Mercedes-Benz E-Class E 450 4MATICWhite 2022 Mercedes-Benz E-Class E 450 4MATICWhite 2022 Mercedes-Benz E-Class E 450 4MATICWhite 2022 Mercedes-Benz E-Class E 450 4MATICWhite 2022 Mercedes-Benz E-Class E 450 4MATICWhite 2022 Mercedes-Benz E-Class E 450 4MATIC

    $46,100

    31,600 mi.
    Est. $819/mo

    Veloce Auto Center & Leasing

    Long Beach, CA (1,728 mi)
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  • Selenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $44,522

    28,332 mi.
    Est. $791/mo

    111 Motorcars

    Franklin, TN (416 mi)
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  • Moonlight 2022 Mercedes-Benz E-Class E 450Moonlight 2022 Mercedes-Benz E-Class E 450Moonlight 2022 Mercedes-Benz E-Class E 450Moonlight 2022 Mercedes-Benz E-Class E 450Moonlight 2022 Mercedes-Benz E-Class E 450Moonlight 2022 Mercedes-Benz E-Class E 450

    $32,209

    $876
    88,899 mi.
    Est. $572/mo

    Capital City Mitsubishi

    Tallahassee, FL (811 mi)
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  • Green 2022 Mercedes-Benz E-Class E 450Green 2022 Mercedes-Benz E-Class E 450Green 2022 Mercedes-Benz E-Class E 450Green 2022 Mercedes-Benz E-Class E 450Green 2022 Mercedes-Benz E-Class E 450Green 2022 Mercedes-Benz E-Class E 450

    $54,994

    36,223 mi.
    Est. $976/mo

    Bluebonnet Ford

    New Braunfels, TX (1,027 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $47,998

    $1K
    17,427 mi.
    Est. $852/mo

    CarMax Gastonia

    3.9
    Gastonia, NC (576 mi)
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  • White 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATIC

    $38,997

    43,285 mi.
    Est. $692/mo

    Smart Ford South Boston

    3.8
    South Boston, VA (589 mi)
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  • Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450

    $57,285

    $440
    16,577 mi.
    Est. $1,017/mo

    Land Rover San Diego

    3.7
    San Diego, CA (1,724 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 450 4MATIC 3 Good deals
2025 Mercedes-Benz E-Class E 450 4MATIC $66,691 5 Great deals
2023 Mercedes-Benz E-Class E 450 4MATIC $47,731 36 Great deals
2021 Mercedes-Benz E-Class E 450 4MATIC $41,567 15 Great deals
2020 Mercedes-Benz E-Class E 450 4MATIC $34,956 10 Great deals
2019 Mercedes-Benz E-Class E 450 4MATIC $30,475 10 Great deals

About the 2022 Mercedes-Benz E-Class E 450 4MATIC

Basics

E 450 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
25
Transmission
9-Speed A/T
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2022 Mercedes-Benz E-Class E 450 4MATIC
FAQs

How much does the 2022 Mercedes-Benz E-Class E 450 4MATIC cost?

The 2022 Mercedes-Benz E-Class E 450 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class E 450 4MATIC is $45,769, with pricing starting at $30,980.

What is the MPG of the 2022 Mercedes-Benz E-Class E 450 4MATIC?

The 2022 Mercedes-Benz E-Class E 450 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 25 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Mercedes-Benz E-Class E 450 4MATIC?

The 2022 Mercedes-Benz E-Class E 450 4MATIC compares to and/or competes against the following vehicles:


Is the 2022 Mercedes-Benz E-Class E 450 4MATIC reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 450 (6 styles)

Style
E 450 4MATIC All-Terrain Wagon E 450 4MATIC Coupe E 450 RWD Coupe E 450 4MATIC Sedan E 450 RWD Cabriolet E 450 4MATIC Cabriolet
Inventory price
Starting at $68,400 Starting at $68,600 Starting at $66,100 Starting at $62,750 Starting at $73,250 Starting at $75,750
Combined MPG
24 24 25 25 25 24
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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Mercedes-Benz E-Class trims