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  • Polar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $47,154

    $200
    45,875 mi.
    Est. $886/mo

    Mercedes-Benz of Foothill Ranch

    4.8
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    Lake Forest, CA (1,725 mi)

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  • Blue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATIC

    $52,000

    45,841 mi.
    Est. $977/mo

    Jessup Auto Plaza

    4.6
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    Cathedral City, CA (1,661 mi)
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  • Selenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $41,725

    45,564 mi.
    Est. $784/mo

    Mercedes-Benz of Sarasota

    4.6
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    SARASOTA, FL (1,052 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC

    $46,900

    13,426 mi.
    Est. $882/mo

    Crown Dodge Chrysler Jeep Ram - CA

    4.1
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    Ventura, CA (1,785 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450

    $47,475

    $1K
    29,421 mi.
    Est. $892/mo

    Easterns Automotive Group of Laurel

    4.9
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    Laurel, MD (600 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $41,994

    $899
    41,795 mi.
    Est. $789/mo

    Ed Hicks Imports

    5.0
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    Corpus Christi, TX (1,123 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $43,998

    30,300 mi.
    Est. $827/mo

    CarMax Garland

    4.6
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    Garland, TX (795 mi)
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  • Mojave Silver Metallic 2022 Mercedes-Benz E-Class E 450 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 450 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 450 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 450 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 450 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC

    $42,791

    $600
    31,778 mi.
    Est. $804/mo

    Chrysler Dodge Jeep Ram of Tampa Bay

    4.5
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    Tampa, FL (1,000 mi)
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  • Grey 2022 Mercedes-Benz E-Class 4MATICGrey 2022 Mercedes-Benz E-Class 4MATICGrey 2022 Mercedes-Benz E-Class 4MATICGrey 2022 Mercedes-Benz E-Class 4MATICGrey 2022 Mercedes-Benz E-Class 4MATICGrey 2022 Mercedes-Benz E-Class 4MATIC

    $42,500

    $488
    43,817 mi.
    Est. $799/mo

    Mercedes-Benz of San Diego

    4.8
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    San Diego, CA (1,727 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $40,000

    47,357 mi.
    Est. $752/mo

    Weikert Ford

    4.7
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    Lake Wales, FL (1,023 mi)
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  • Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450

    $44,773

    29,699 mi.
    Est. $842/mo

    Land Rover Boerne

    4.7
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    Boerne, TX (1,041 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $49,995

    17,273 mi.
    Est. $940/mo

    Sandy Sansing BMW

    4.7
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    Pensacola, FL (789 mi)
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  • MANUFAKTUR Moonlight White 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Moonlight White 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Moonlight White 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Moonlight White 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Moonlight White 2022 Mercedes-Benz E-Class E 450MANUFAKTUR Moonlight White 2022 Mercedes-Benz E-Class E 450

    $60,885

    23,672 mi.
    Est. $1,144/mo

    Mercedes-Benz of Buckhead

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    Atlanta, GA (585 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $38,998

    $2K
    42,769 mi.
    Est. $733/mo

    Husker High Line

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    Lincoln, NE (474 mi)
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  • White 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATIC

    $43,597

    $166
    45,550 mi.
    Est. $819/mo

    Wyatt Johnson Hyundai

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    Clarksville, TN (368 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $48,990

    39,285 mi.
    Est. $921/mo

    Vision Motors

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    Garden Grove, CA (1,737 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450

    $41,867

    18,885 mi.
    Est. $787/mo

    Merit Auto Group

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    Jacksonville, FL (861 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATIC

    $48,500

    $1.3K
    17,542 mi.
    Est. $912/mo

    Mercedes-Benz of Chantilly

    3.6
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    Chantilly, VA (574 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATIC

    $44,997

    $5.7K
    16,140 mi.
    Est. $846/mo

    HGreg.com Houston

    3.5
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    Houston, TX (949 mi)
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  • Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 RWD CoupeObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 RWD CoupeObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 RWD CoupeObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 RWD CoupeObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 RWD CoupeObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 RWD Coupe

    $41,893

    $1K
    36,012 mi.
    Est. $787/mo

    Fletcher Jones Motorcars

    4.5
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    Newport Beach, CA (1,736 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $39,999

    48,205 mi.
    Est. $752/mo

    Mercedes-Benz of Fort Lauderdale

    4.0
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    Fort Lauderdale, FL (1,172 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450

    $47,215

    11,652 mi.
    Est. $887/mo

    Mercedes-Benz of Houston Greenway

    4.5
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    Houston, TX (946 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $35,481

    75,734 mi.
    Est. $667/mo

    Mercedes-Benz of West Chester (PA)

    4.5
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    West Chester, PA (645 mi)
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  • Diamond White 2022 Mercedes-Benz E-Class 4MATICDiamond White 2022 Mercedes-Benz E-Class 4MATICDiamond White 2022 Mercedes-Benz E-Class 4MATICDiamond White 2022 Mercedes-Benz E-Class 4MATICDiamond White 2022 Mercedes-Benz E-Class 4MATICDiamond White 2022 Mercedes-Benz E-Class 4MATIC

    $59,998

    761 mi.
    Est. $1,128/mo

    Mercedes-Benz of Wichita

    4.6
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    Wichita, KS (584 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 450 4MATIC 2 Good deals
2025 Mercedes-Benz E-Class E 450 4MATIC $64,683 11 Great deals
2024 Mercedes-Benz E-Class E 450 4MATIC $64,294 6 Great deals
2023 Mercedes-Benz E-Class E 450 4MATIC $48,620 53 Great deals
2021 Mercedes-Benz E-Class E 450 4MATIC $42,349 22 Great deals
2020 Mercedes-Benz E-Class E 450 4MATIC $33,277 9 Great deals
2019 Mercedes-Benz E-Class E 450 4MATIC $30,189 23 Great deals

About the 2022 Mercedes-Benz E-Class E 450 4MATIC

Basics

E 450 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
25
Transmission
9-Speed A/T
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2022 Mercedes-Benz E-Class E 450 4MATIC
FAQs

How much does the 2022 Mercedes-Benz E-Class E 450 4MATIC cost?

The 2022 Mercedes-Benz E-Class E 450 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class E 450 4MATIC is $45,108, with pricing starting at $32,998.

What is the MPG of the 2022 Mercedes-Benz E-Class E 450 4MATIC?

The 2022 Mercedes-Benz E-Class E 450 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 25 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Mercedes-Benz E-Class E 450 4MATIC?

The 2022 Mercedes-Benz E-Class E 450 4MATIC compares to and/or competes against the following vehicles:


Is the 2022 Mercedes-Benz E-Class E 450 4MATIC reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 450 (6 styles)

Style
E 450 4MATIC All-Terrain Wagon E 450 4MATIC Coupe E 450 RWD Coupe E 450 4MATIC Sedan E 450 RWD Cabriolet E 450 4MATIC Cabriolet
Inventory price
Starting at $68,400 Starting at $68,600 Starting at $66,100 Starting at $62,750 Starting at $73,250 Starting at $75,750
Combined MPG
24 24 25 25 25 24
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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Mercedes-Benz E-Class trims