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  • Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450

    $42,989

    $500
    31,715 mi.
    Est. $810/mo

    Mercedes-Benz of Miami

    4.4
    Miami, FL (1,181 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $38,189

    $405
    46,226 mi.
    Est. $719/mo

    Lugoff Ford

    4.2
    Lugoff, SC (651 mi)
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  • Mojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $43,790

    $180
    25,823 mi.
    Est. $825/mo

    Mercedes-Benz of Lafayette

    Lafayette, LA (847 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $44,887

    23,780 mi.
    Est. $846/mo

    Motor Werks Cadillac

    4.8
    Barrington, IL (32 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450

    $41,153

    35,051 mi.
    Est. $775/mo

    AutoNation Ford St. Petersburg

    4.4
    St Petersburg, FL (1,013 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $33,487

    45,304 mi.
    Est. $631/mo

    The Sharpest Rides

    4.4
    Englewood, CO (920 mi)
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  • Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450

    $57,693

    $604
    15,723 mi.
    Est. $1,087/mo

    Mercedes-Benz of Raleigh

    4.7
    Raleigh, NC (640 mi)
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  • Rubellite Red Metallic 2022 Mercedes-Benz E-Class 4MATICRubellite Red Metallic 2022 Mercedes-Benz E-Class 4MATICRubellite Red Metallic 2022 Mercedes-Benz E-Class 4MATICRubellite Red Metallic 2022 Mercedes-Benz E-Class 4MATICRubellite Red Metallic 2022 Mercedes-Benz E-Class 4MATICRubellite Red Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $43,349

    $440
    29,401 mi.
    Est. $817/mo

    BMW MINI of Annapolis

    4.6
    Annapolis, MD (619 mi)
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  • White 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATIC

    $42,297

    $300
    39,415 mi.
    Est. $797/mo

    Mercedes-Benz of Newton

    4.0
    Newton, NJ (670 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450

    $38,274

    $4.1K
    47,886 mi.
    Est. $721/mo

    Mercedes-Benz of Naples

    4.9
    Naples, FL (1,138 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450

    $44,312

    27,794 mi.
    Est. $835/mo

    DallasLeaseReturns.com

    5.0
    Dallas, TX (797 mi)
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  • Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450

    $43,599

    75,510 mi.
    Est. $821/mo

    Mercedes-Benz of Valencia

    4.2
    Santa Clarita, CA (1,746 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC

    $38,579

    $500
    37,738 mi.
    Est. $727/mo

    Ferguson Superstore

    4.9
    Broken Arrow, OK (594 mi)
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  • Graphite Gray Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $42,971

    $1.5K
    29,558 mi.
    Est. $810/mo

    Courtesy Ford - Portland

    4.5
    Portland, OR (1,748 mi)
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  • Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 450Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 450Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 450Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 450Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 450Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 450

    $53,993

    $500
    43,593 mi.
    Est. $1,017/mo

    Mercedes-Benz of Ft. Pierce

    4.9
    Fort Pierce, FL (1,084 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450

    $41,995

    $2K
    41,313 mi.
    Est. $791/mo

    Accurate Automotive of Jacksonville

    4.9
    Jacksonville, FL (873 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450

    $33,989

    69,062 mi.
    Est. $640/mo

    AutoNation Lincoln Orange Park

    4.5
    Jacksonville, FL (871 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450Polar White 2022 Mercedes-Benz E-Class E 450

    $47,271

    25,912 mi.
    Est. $891/mo

    Rainbow Mitsubishi North

    4.9
    Covington, LA (802 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC

    $41,995

    $5K
    34,616 mi.
    Est. $791/mo

    Payless Car Sales - Anchorage

    4.1
    Anchorage, AK (2,849 mi)
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  • Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450

    $31,998

    $524
    65,942 mi.
    Est. $603/mo

    Land Rover West Houston

    4.8
    Katy, TX (950 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450Black 2022 Mercedes-Benz E-Class E 450

    $33,989

    69,062 mi.
    Est. $640/mo

    AutoNation Ford Orange Park

    4.6
    Jacksonville, FL (871 mi)
    Check Availability

  • Polar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATICPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC

    $43,204

    26,718 mi.
    Est. $814/mo

    Mercedes-Benz of St. Charles

    4.7
    Saint Charles, IL (37 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $48,998

    29,713 mi.
    Est. $923/mo

    CarMax Reno

    4.6
    Reno, NV (1,683 mi)
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  • Diamond White 2022 Mercedes-Benz E-Class E 450 4MATICDiamond White 2022 Mercedes-Benz E-Class E 450 4MATICDiamond White 2022 Mercedes-Benz E-Class E 450 4MATICDiamond White 2022 Mercedes-Benz E-Class E 450 4MATICDiamond White 2022 Mercedes-Benz E-Class E 450 4MATICDiamond White 2022 Mercedes-Benz E-Class E 450 4MATIC

    $53,369

    24,193 mi.
    Est. $1,005/mo

    Mercedes-Benz of San Juan

    4.9
    San Juan, TX (1,238 mi)
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  • Gray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-Class

    $54,998

    12,220 mi.
    Est. $1,036/mo

    CarMax San Gabriel Valley/Duarte

    4.5
    Duarte, CA (1,726 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $39,998

    32,625 mi.
    Est. $754/mo

    CarMax Stockton

    4.8
    Stockton, CA (1,790 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $45,806

    49,473 mi.
    Est. $863/mo

    Mercedes-Benz of Foothill Ranch

    4.8
    Lake Forest, CA (1,725 mi)
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  • Gray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATIC

    $36,430

    $1K
    51,142 mi.
    Est. $686/mo

    Lia Toyota of Wilbraham

    4.4
    Wilbraham, MA (778 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $39,998

    37,147 mi.
    Est. $754/mo

    CarMax Tampa

    4.2
    Tampa, FL (997 mi)
    Check Availability

Mercedes-Benz E-Class prices by year

Model year Average price Deals
2027 Mercedes-Benz E-Class E 450 4MATIC 6 Good deals
2026 Mercedes-Benz E-Class E 450 4MATIC 8 Good deals
2025 Mercedes-Benz E-Class E 450 4MATIC $63,313 15 Great deals
2024 Mercedes-Benz E-Class E 450 4MATIC $62,348 6 Great deals
2023 Mercedes-Benz E-Class E 450 4MATIC $45,436 64 Great deals
2021 Mercedes-Benz E-Class E 450 4MATIC $38,504 7 Great deals
2020 Mercedes-Benz E-Class E 450 4MATIC $33,934 17 Great deals
2019 Mercedes-Benz E-Class E 450 4MATIC $27,527 8 Great deals

About the 2022 Mercedes-Benz E-Class E 450 4MATIC

Basics

E 450 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
25
Transmission
9-Speed A/T
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2022 Mercedes-Benz E-Class E 450 4MATIC
FAQs

How much does the 2022 Mercedes-Benz E-Class E 450 4MATIC cost?

The 2022 Mercedes-Benz E-Class E 450 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class E 450 4MATIC is $42,347, with pricing starting at $25,495.

What is the MPG of the 2022 Mercedes-Benz E-Class E 450 4MATIC?

The 2022 Mercedes-Benz E-Class E 450 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 25 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Mercedes-Benz E-Class E 450 4MATIC?

The 2022 Mercedes-Benz E-Class E 450 4MATIC compares to and/or competes against the following vehicles:


Is the 2022 Mercedes-Benz E-Class E 450 4MATIC reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 450 (6 styles)

Style
E 450 4MATIC All-Terrain Wagon E 450 4MATIC Coupe E 450 RWD Coupe E 450 4MATIC Sedan E 450 RWD Cabriolet E 450 4MATIC Cabriolet
Inventory price
Starting at $68,400 Starting at $68,600 Starting at $66,100 Starting at $62,750 Starting at $73,250 Starting at $75,750
Combined MPG
24 24 25 25 25 24
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)

2022 Mercedes-Benz E-Class trims