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  • Polar White 2021 Mercedes-Benz E-Class E 350 4MATICPolar White 2021 Mercedes-Benz E-Class E 350 4MATICPolar White 2021 Mercedes-Benz E-Class E 350 4MATIC

    $32,164

    58,993 mi.
    Est. $571/mo

    Johnson Hyundai of Wake Forest

    4.5
    Wake Forest, NC (638 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $33,197

    49,740 mi.
    Est. $589/mo

    Johnson Ford of Burlington

    4.5
    Burlington, NJ (678 mi)
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  • Selenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $33,898

    $2.1K
    31,422 mi.
    Est. $602/mo

    Mercedes-Benz of Fort Lauderdale

    4.1
    Fort Lauderdale, FL (1,172 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATIC

    $33,000

    49,652 mi.
    Est. $586/mo

    Peters Chevrolet

    4.4
    Longview, TX (753 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $39,025

    29,129 mi.
    Est. $693/mo

    Mercedes-Benz of Buffalo

    4.8
    Williamsville, NY (463 mi)
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  • Graphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $35,885

    38,737 mi.
    Est. $637/mo

    D-Patrick Motoplex

    4.5
    Evansville, IN (270 mi)
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  • Obsidian Black 2021 Mercedes-Benz E-Class 4MATICObsidian Black 2021 Mercedes-Benz E-Class 4MATICObsidian Black 2021 Mercedes-Benz E-Class 4MATICObsidian Black 2021 Mercedes-Benz E-Class 4MATICObsidian Black 2021 Mercedes-Benz E-Class 4MATICObsidian Black 2021 Mercedes-Benz E-Class 4MATIC

    $32,680

    40,132 mi.
    Est. $580/mo

    Porsche Englewood

    4.7
    Englewood, NJ (711 mi)
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  • Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $32,687

    25,056 mi.
    Est. $580/mo

    Fred Anderson Subaru

    4.8
    Asheville, NC (515 mi)
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  • Silver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-Class

    $33,998

    27,458 mi.
    Est. $604/mo

    CarMax Lithia Springs

    4.7
    Lithia Springs, GA (584 mi)
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  • White 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATIC

    $34,900

    90,054 mi.
    Est. $620/mo

    Car2Sell

    4.1
    Hillside, NJ (701 mi)
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  • designo Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATIC

    $32,529

    $370
    24,045 mi.
    Est. $578/mo

    Volkswagen of Streetsboro

    4.6
    Streetsboro, OH (328 mi)
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  • Silver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATIC

    $31,995

    56,180 mi.
    Est. $568/mo

    Fellini Auto Sales & Service of PITTSBURGH

    PITTSBURGH, PA (411 mi)
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  • Graphite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $33,198

    $700
    53,851 mi.
    Est. $589/mo

    Karma DFW Plano

    Plano, TX (791 mi)
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  • Gray 2021 Mercedes-Benz E-Class E 350 4MATICGray 2021 Mercedes-Benz E-Class E 350 4MATICGray 2021 Mercedes-Benz E-Class E 350 4MATICGray 2021 Mercedes-Benz E-Class E 350 4MATICGray 2021 Mercedes-Benz E-Class E 350 4MATICGray 2021 Mercedes-Benz E-Class E 350 4MATIC

    $36,578

    47,143 mi.
    Est. $649/mo

    The Car Store

    Salisbury, MD (681 mi)
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  • designo Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATIC

    $34,600

    43,500 mi.
    Est. $614/mo

    Mercedes-Benz Of Oklahoma City

    4.7
    Oklahoma City, OK (685 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $28,981

    $1K
    58,301 mi.
    Est. $515/mo

    Mercedes-Benz of Houston Greenway

    4.5
    Houston, TX (946 mi)
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  • Silver 2021 Mercedes-Benz E-Class E 350 4MATICSilver 2021 Mercedes-Benz E-Class E 350 4MATICSilver 2021 Mercedes-Benz E-Class E 350 4MATICSilver 2021 Mercedes-Benz E-Class E 350 4MATICSilver 2021 Mercedes-Benz E-Class E 350 4MATICSilver 2021 Mercedes-Benz E-Class E 350 4MATIC

    $35,936

    $2.5K
    31,803 mi.
    Est. $638/mo

    Mercedes-Benz of North Haven

    4.2
    North Haven, CT (764 mi)
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  • Silver Grey 2021 Mercedes-Benz E-Class 4MATICSilver Grey 2021 Mercedes-Benz E-Class 4MATICSilver Grey 2021 Mercedes-Benz E-Class 4MATICSilver Grey 2021 Mercedes-Benz E-Class 4MATICSilver Grey 2021 Mercedes-Benz E-Class 4MATICSilver Grey 2021 Mercedes-Benz E-Class 4MATIC

    $29,349

    $1K
    53,429 mi.
    Est. $521/mo

    Autos of Chicago

    4.3
    Arlington Heights, IL (23 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATIC

    $19,599

    138,696 mi.
    Est. $348/mo

    PK Auto Sales

    4.2
    Stafford, VA (590 mi)
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  • Gray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATIC

    $34,000

    54,986 mi.
    Est. $604/mo

    Mercedes-Benz of Annapolis

    4.9
    Annapolis, MD (620 mi)
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  • Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $24,484

    $1K
    88,412 mi.
    Est. $435/mo

    DCH Montclair Acura

    4.5
    Verona, NJ (699 mi)
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  • Gray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $37,995

    24,448 mi.
    Est. $675/mo

    Ray Catena Mercedes Benz Freehold

    4.9
    Freehold, NJ (703 mi)
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  • Polar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATIC

    $28,495

    24,835 mi.
    Est. $506/mo

    Victory Mitsubishi

    3.3
    Bronx, NY (719 mi)
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  • White 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATIC

    $28,995

    47,889 mi.
    Est. $515/mo

    Suburban Chevrolet Cadillac of Ann Arbor

    4.3
    Ann Arbor, MI (199 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 350 4MATIC 39 Great deals
2025 Mercedes-Benz E-Class E 350 4MATIC $57,330 11 Great deals
2024 Mercedes-Benz E-Class E 350 4MATIC $54,160 26 Great deals
2023 Mercedes-Benz E-Class E 350 4MATIC $42,058 9 Great deals
2022 Mercedes-Benz E-Class E 350 4MATIC $36,580 9 Great deals
2020 Mercedes-Benz E-Class E 350 4MATIC $26,916 12 Great deals
2016 Mercedes-Benz E-Class E 350 4MATIC $16,328 11 Great deals
2015 Mercedes-Benz E-Class E 350 4MATIC $14,164 5 Good deals
2014 Mercedes-Benz E-Class E 350 4MATIC $12,588 13 Great deals

About the 2021 Mercedes-Benz E-Class E 350 4MATIC

Basics

E 350 shown (base trim).

Seating
5
Door count
4
Drivetrain
Rear-wheel drive
Combined MPG
25
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Mercedes-Benz E-Class E 350 4MATIC
FAQs

How much does the 2021 Mercedes-Benz E-Class E 350 4MATIC cost?

The 2021 Mercedes-Benz E-Class E 350 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class E 350 4MATIC is $30,876, with pricing starting at $19,599.

What is the MPG of the 2021 Mercedes-Benz E-Class E 350 4MATIC?

The 2021 Mercedes-Benz E-Class E 350 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 25 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz E-Class E 350 4MATIC?

The 2021 Mercedes-Benz E-Class E 350 4MATIC compares to and/or competes against the following vehicles:


Is the 2021 Mercedes-Benz E-Class E 350 4MATIC reliable?

The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.

Is the 2021 Mercedes-Benz E-Class E 350 4MATIC a good sedan?

Below are the Cars.com consumer ratings for the 2021 Mercedes-Benz E-Class.

(9 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Ratings (9 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Trims

E 350 (2 styles)

Style
E 350 RWD Sedan E 350 4MATIC Sedan
Inventory price
Starting at $54,250 Starting at $56,750
Combined MPG
25 25
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel) 255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)

E 450 (6 styles)

Style
E 450 4MATIC Coupe E 450 RWD Coupe E 450 4MATIC Sedan E 450 4MATIC Cabriolet E 450 4MATIC All-Terrain Wagon E 450 RWD Cabriolet
Inventory price
Starting at $67,450 Starting at $64,950 Starting at $62,000 Starting at $74,450 Starting at $67,600 Starting at $71,950
Combined MPG
25 26 26 25 24 25
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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Mercedes-Benz E-Class trims