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  • Black 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATIC

    $27,499

    46,407 mi.
    Est. $518/mo

    Westchester Motors

    Yonkers, NY (717 mi)
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  • Polar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATIC

    $32,786

    30,451 mi.
    Est. $618/mo

    North Orlando Mitsubishi

    4.3
    Orlando, FL (985 mi)
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  • Cirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $29,111

    $1K
    40,410 mi.
    Est. $548/mo

    Shottenkirk Toyota of Weatherford

    4.8
    Weatherford, TX (838 mi)
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  • Silver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATIC

    $22,329

    85,515 mi.
    Est. $421/mo

    CarsIndex - Horsham

    4.7
    Horsham, PA (663 mi)
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  • Lunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $28,745

    44,714 mi.
    Est. $542/mo

    AutoGiant USA

    3.6
    Indianapolis, IN (162 mi)
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  • designo Diamond White Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $33,848

    54,768 mi.
    Est. $638/mo

    Viti, Inc.

    4.9
    Tiverton, RI (847 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $31,676

    39,484 mi.
    Est. $597/mo

    Star Motor Sales

    4.5
    Downers Grove, IL (21 mi)
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  • Cirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $33,190

    29,341 mi.
    Est. $625/mo

    AutoLenders Toms River

    4.8
    Toms River, NJ (716 mi)
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  • BLACK 2021 Mercedes-Benz E-Class 4MATICBLACK 2021 Mercedes-Benz E-Class 4MATICBLACK 2021 Mercedes-Benz E-Class 4MATICBLACK 2021 Mercedes-Benz E-Class 4MATICBLACK 2021 Mercedes-Benz E-Class 4MATICBLACK 2021 Mercedes-Benz E-Class 4MATIC

    $33,338

    37,648 mi.
    Est. $628/mo

    Conway Imports

    4.2
    Streamwood, IL (29 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $28,895

    50,120 mi.
    Est. $544/mo

    Unique Auto Mall

    4.7
    South Amboy, NJ (701 mi)
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  • Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $27,795

    $520
    65,839 mi.
    Est. $524/mo

    Frankfort Auto Haus

    4.9
    Frankfort, IL (27 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATIC

    $30,987

    $1K
    54,977 mi.
    Est. $584/mo

    Rocky Mountain Auto Brokers Inc.

    4.0
    Colorado Springs, CO (921 mi)
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  • Cirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $28,086

    72,450 mi.
    Est. $529/mo

    Mercedes-Benz of Easton

    4.9
    Columbus, OH (277 mi)
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  • Cavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $27,198

    52,875 mi.
    Est. $512/mo

    Auto Boutique of Columbus

    4.8
    Columbus, OH (273 mi)
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  • Silver Metallic 2021 Mercedes-Benz E-Class 4MATICSilver Metallic 2021 Mercedes-Benz E-Class 4MATICSilver Metallic 2021 Mercedes-Benz E-Class 4MATICSilver Metallic 2021 Mercedes-Benz E-Class 4MATICSilver Metallic 2021 Mercedes-Benz E-Class 4MATICSilver Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $37,590

    $100
    15,738 mi.
    Est. $708/mo

    Mercedes-Benz of Owings Mills

    4.9
    Owings Mills, MD (595 mi)
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  • Not Specified 2021 Mercedes-Benz E-Class 4MATICNot Specified 2021 Mercedes-Benz E-Class 4MATICNot Specified 2021 Mercedes-Benz E-Class 4MATICNot Specified 2021 Mercedes-Benz E-Class 4MATICNot Specified 2021 Mercedes-Benz E-Class 4MATICNot Specified 2021 Mercedes-Benz E-Class 4MATIC

    $27,985

    64,130 mi.
    Est. $527/mo

    Alpha Luxury Motors

    3.7
    Downers Grove, IL (20 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $28,950

    42,546 mi.
    Est. $545/mo

    Easterns Automotive Group of Temple Hills

    4.9
    Temple Hills, MD (601 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $23,774

    68,160 mi.
    Est. $448/mo

    CarGet Motors

    4.1
    Woodbridge, VA (591 mi)
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  • Lunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $33,385

    41,216 mi.
    Est. $629/mo

    Viti, Inc.

    4.9
    Tiverton, RI (847 mi)
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  • White 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATIC

    $29,095

    $500
    51,893 mi.
    Est. $548/mo

    Cars Land

    3.9
    Tempe, AZ (1,444 mi)
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  • WHITE 2021 Mercedes-Benz E-Class E 350 4MATICWHITE 2021 Mercedes-Benz E-Class E 350 4MATICWHITE 2021 Mercedes-Benz E-Class E 350 4MATICWHITE 2021 Mercedes-Benz E-Class E 350 4MATICWHITE 2021 Mercedes-Benz E-Class E 350 4MATICWHITE 2021 Mercedes-Benz E-Class E 350 4MATIC

    $29,975

    36,346 mi.
    Est. $565/mo

    Clare Auto Sales

    Clare, MI (198 mi)
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  • Silver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATIC

    $33,999

    10,912 mi.
    Est. $641/mo

    Autopia Motorcars Inc

    4.1
    Union, NJ (699 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATIC

    $29,000

    $1K
    49,652 mi.
    Est. $546/mo

    Peters Chevrolet

    4.5
    Longview, TX (753 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATIC

    $27,499

    46,407 mi.
    Est. $518/mo

    Westchester Motors

    Yonkers, NY (717 mi)
    Check Availability
  • Silver 2021 Mercedes-Benz E-Class 4MATICSilver 2021 Mercedes-Benz E-Class 4MATIC

    $25,779

    55,033 mi.
    Est. $486/mo

    Easterns Automotive Group of Sterling

    4.8
    Sterling, VA (571 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 350 4MATIC 80 Great deals
2025 Mercedes-Benz E-Class E 350 4MATIC $50,848 7 Great deals
2024 Mercedes-Benz E-Class E 350 4MATIC $50,597 38 Great deals
2023 Mercedes-Benz E-Class E 350 4MATIC $40,222 46 Great deals
2022 Mercedes-Benz E-Class E 350 4MATIC $34,069 6 Great deals
2020 Mercedes-Benz E-Class E 350 4MATIC $25,123 21 Great deals
2016 Mercedes-Benz E-Class E 350 4MATIC $15,338 11 Great deals
2015 Mercedes-Benz E-Class E 350 4MATIC $13,300 8 Great deals
2014 Mercedes-Benz E-Class E 350 4MATIC $12,335 32 Great deals

About the 2021 Mercedes-Benz E-Class E 350 4MATIC

Basics

E 350 shown (base trim).

Seating
5
Door count
4
Drivetrain
Rear-wheel drive
Combined MPG
25
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Mercedes-Benz E-Class E 350 4MATIC
FAQs

How much does the 2021 Mercedes-Benz E-Class E 350 4MATIC cost?

The 2021 Mercedes-Benz E-Class E 350 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class E 350 4MATIC is $29,469, with pricing starting at $22,329.

What is the MPG of the 2021 Mercedes-Benz E-Class E 350 4MATIC?

The 2021 Mercedes-Benz E-Class E 350 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 25 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz E-Class E 350 4MATIC?

The 2021 Mercedes-Benz E-Class E 350 4MATIC compares to and/or competes against the following vehicles:


Is the 2021 Mercedes-Benz E-Class E 350 4MATIC reliable?

The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.

Is the 2021 Mercedes-Benz E-Class E 350 4MATIC a good sedan?

Below are the Cars.com consumer ratings for the 2021 Mercedes-Benz E-Class.

(9 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Ratings (9 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Trims

E 350 (2 styles)

Style
E 350 RWD Sedan E 350 4MATIC Sedan
Inventory price
Starting at $54,250 Starting at $56,750
Combined MPG
25 25
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel) 255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)

E 450 (6 styles)

Style
E 450 4MATIC Coupe E 450 RWD Coupe E 450 4MATIC Sedan E 450 4MATIC Cabriolet E 450 4MATIC All-Terrain Wagon E 450 RWD Cabriolet
Inventory price
Starting at $67,450 Starting at $64,950 Starting at $62,000 Starting at $74,450 Starting at $67,600 Starting at $71,950
Combined MPG
25 26 26 25 24 25
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)

2021 Mercedes-Benz E-Class trims