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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $32,141

    58,301 mi.
    Est. $604/mo

    Mercedes-Benz of Houston Greenway

    4.5
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    Houston, TX (946 mi)

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  • Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $33,991

    $1K
    31,099 mi.
    Est. $639/mo

    Porsche Naples

    4.9
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    Naples, FL (1,138 mi)

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  • Cirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $36,198

    34,207 mi.
    Est. $680/mo

    AutoNation Toyota Thornton Road

    4.6
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    Lithia Springs, GA (585 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATIC

    $25,677

    105,356 mi.
    Est. $483/mo

    Ira Ford Auburn

    4.8
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    Auburn, MA (810 mi)
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  • designo Diamond White Metallic 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $36,395

    $100
    27,637 mi.
    Est. $684/mo

    Mercedes-Benz of Naples

    4.8
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    Naples, FL (1,138 mi)
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  • White 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATIC

    $29,995

    47,889 mi.
    Est. $564/mo

    Suburban Chevrolet Cadillac of Ann Arbor

    4.3
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    Ann Arbor, MI (199 mi)
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  • Polar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATIC

    $36,450

    37,839 mi.
    Est. $685/mo

    Select Auto Imports

    5.0
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    Alexandria, VA (593 mi)
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  • designo Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATICdesigno Diamond White 2021 Mercedes-Benz E-Class E 350 4MATIC

    $40,400

    19,500 mi.
    Est. $759/mo

    Mercedes-Benz of Portsmouth

    4.5
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    Greenland, NH (860 mi)
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  • designo Cardinal Red Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red Metallic 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $27,999

    85,357 mi.
    Est. $526/mo

    Billion Auto - Chevrolet

    4.3
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    Sioux Falls, SD (478 mi)
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  • Polar White 2021 Mercedes-Benz E-Class E 350 4MATICPolar White 2021 Mercedes-Benz E-Class E 350 4MATICPolar White 2021 Mercedes-Benz E-Class E 350 4MATICPolar White 2021 Mercedes-Benz E-Class E 350 4MATICPolar White 2021 Mercedes-Benz E-Class E 350 4MATICPolar White 2021 Mercedes-Benz E-Class E 350 4MATIC

    $34,284

    $1.5K
    22,759 mi.
    Est. $644/mo

    Transitowne Dodge Chrysler Jeep RAM of West Seneca

    4.4
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    Elma, NY (462 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATIC

    $28,798

    $2.2K
    45,628 mi.
    Est. $541/mo

    BMW of Lenox

    4.6
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    Lenox, MA (737 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATICBlack 2021 Mercedes-Benz E-Class E 350 4MATIC

    $33,000

    49,652 mi.
    Est. $620/mo

    Peters Chevrolet

    4.4
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    Longview, TX (753 mi)
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  • White 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATIC

    $33,777

    77,531 mi.
    Est. $635/mo

    Mercedes-Benz of Abilene

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    Abilene, TX (934 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350 4MATIC®Black 2021 Mercedes-Benz E-Class E 350 4MATIC®Black 2021 Mercedes-Benz E-Class E 350 4MATIC®Black 2021 Mercedes-Benz E-Class E 350 4MATIC®Black 2021 Mercedes-Benz E-Class E 350 4MATIC®Black 2021 Mercedes-Benz E-Class E 350 4MATIC®

    $31,998

    85,368 mi.
    Est. $601/mo

    Widrick Auto Sales

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    Watertown, NY (610 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $38,980

    26,645 mi.
    Est. $733/mo

    Mercedes-Benz of Alexandria

    3.5
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    Alexandria, VA (593 mi)
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  • White 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATICWhite 2021 Mercedes-Benz E-Class E 350 4MATIC

    $28,799

    $200
    55,456 mi.
    Est. $541/mo

    Performance Mitsubishi (FL)

    4.0
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    Delray Beach, FL (1,148 mi)
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  • designo Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATICdesigno Cardinal Red 2021 Mercedes-Benz E-Class 4MATIC

    $33,999

    $250
    24,052 mi.
    Est. $639/mo

    Volkswagen of Streetsboro

    4.6
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    Streetsboro, OH (328 mi)
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  • Graphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $29,984

    38,949 mi.
    Est. $564/mo

    RBM of Atlanta

    4.5
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    Atlanta, GA (576 mi)
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  • Graphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $29,255

    $330
    48,073 mi.
    Est. $550/mo

    Mercedes-Benz of Ann Arbor

    4.5
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    Ann Arbor, MI (198 mi)
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  • Blue 2021 Mercedes-Benz E-Class E 350 4MATICBlue 2021 Mercedes-Benz E-Class E 350 4MATICBlue 2021 Mercedes-Benz E-Class E 350 4MATICBlue 2021 Mercedes-Benz E-Class E 350 4MATICBlue 2021 Mercedes-Benz E-Class E 350 4MATICBlue 2021 Mercedes-Benz E-Class E 350 4MATIC

    $32,400

    $500
    35,411 mi.
    Est. $609/mo

    Haus of Imports

    4.3
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    Lemont, IL (20 mi)
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  • Cirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $34,500

    $500
    48,451 mi.
    Est. $648/mo

    Mercedes-Benz of Catonsville

    4.3
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    Baltimore, MD (598 mi)
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  • Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $36,299

    $199
    25,056 mi.
    Est. $682/mo

    Fred Anderson Subaru

    4.7
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    Asheville, NC (515 mi)
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  • Gray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATICGray Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $36,980

    43,667 mi.
    Est. $695/mo

    Mercedes-Benz of Nanuet

    4.9
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    Nanuet, NY (708 mi)
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  • Gray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 350 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 350 4MATIC

    $37,894

    6,705 mi.
    Est. $712/mo

    RBM of Atlanta

    4.5
    Check Availability
    Atlanta, GA (576 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 350 4MATIC 37 Great deals
2025 Mercedes-Benz E-Class E 350 4MATIC $57,212 13 Great deals
2024 Mercedes-Benz E-Class E 350 4MATIC $53,474 33 Great deals
2023 Mercedes-Benz E-Class E 350 4MATIC $42,728 23 Great deals
2022 Mercedes-Benz E-Class E 350 4MATIC $35,968 13 Great deals
2020 Mercedes-Benz E-Class E 350 4MATIC $26,560 14 Great deals
2016 Mercedes-Benz E-Class E 350 4MATIC $16,626 23 Great deals
2015 Mercedes-Benz E-Class E 350 4MATIC $13,901 11 Great deals
2014 Mercedes-Benz E-Class E 350 4MATIC $13,036 47 Great deals

About the 2021 Mercedes-Benz E-Class E 350 4MATIC

Basics

E 350 shown (base trim).

Seating
5
Door count
4
Drivetrain
Rear-wheel drive
Combined MPG
25
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Mercedes-Benz E-Class E 350 4MATIC
FAQs

How much does the 2021 Mercedes-Benz E-Class E 350 4MATIC cost?

The 2021 Mercedes-Benz E-Class E 350 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class E 350 4MATIC is $31,534, with pricing starting at $23,995.

What is the MPG of the 2021 Mercedes-Benz E-Class E 350 4MATIC?

The 2021 Mercedes-Benz E-Class E 350 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 25 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz E-Class E 350 4MATIC?

The 2021 Mercedes-Benz E-Class E 350 4MATIC compares to and/or competes against the following vehicles:


Is the 2021 Mercedes-Benz E-Class E 350 4MATIC reliable?

The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.

Is the 2021 Mercedes-Benz E-Class E 350 4MATIC a good sedan?

Below are the Cars.com consumer ratings for the 2021 Mercedes-Benz E-Class.

(9 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Ratings (9 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Trims

E 350 (2 styles)

Style
E 350 RWD Sedan E 350 4MATIC Sedan
Inventory price
Starting at $54,250 Starting at $56,750
Combined MPG
25 25
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel) 255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)

E 450 (6 styles)

Style
E 450 4MATIC Coupe E 450 RWD Coupe E 450 4MATIC Sedan E 450 4MATIC Cabriolet E 450 4MATIC All-Terrain Wagon E 450 RWD Cabriolet
Inventory price
Starting at $67,450 Starting at $64,950 Starting at $62,000 Starting at $74,450 Starting at $67,600 Starting at $71,950
Combined MPG
25 26 26 25 24 25
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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Mercedes-Benz E-Class trims