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  • Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350

    $25,990

    $300
    52,745 mi.
    Est. $489/mo

    North Miami Mitsubishi

    4.4
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    Miami, FL (1,180 mi)

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  • Selenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $29,900

    50,422 mi.
    Est. $562/mo

    Guaranteed Motor Cars

    3.0
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    palos hills, IL (25 mi)

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  • Silver Metallic 2021 Mercedes-Benz E-Class E 350Silver Metallic 2021 Mercedes-Benz E-Class E 350Silver Metallic 2021 Mercedes-Benz E-Class E 350Silver Metallic 2021 Mercedes-Benz E-Class E 350Silver Metallic 2021 Mercedes-Benz E-Class E 350Silver Metallic 2021 Mercedes-Benz E-Class E 350

    $30,475

    $474
    40,549 mi.
    Est. $573/mo

    Tamiami Hyundai

    4.6
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    Naples, FL (1,132 mi)
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  • Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 350Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 350Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 350Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 350Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 350Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 350

    $25,998

    $1.9K
    66,489 mi.
    Est. $489/mo

    HGreg.com Orlando

    4.5
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    Orlando, FL (994 mi)
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  • Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350

    $30,820

    58,113 mi.
    Est. $579/mo

    House of Imports

    4.6
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    Buena Park, CA (1,736 mi)
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  • Cavansite Blue Metallic 2021 Mercedes-Benz E-Class E 350Cavansite Blue Metallic 2021 Mercedes-Benz E-Class E 350Cavansite Blue Metallic 2021 Mercedes-Benz E-Class E 350Cavansite Blue Metallic 2021 Mercedes-Benz E-Class E 350Cavansite Blue Metallic 2021 Mercedes-Benz E-Class E 350Cavansite Blue Metallic 2021 Mercedes-Benz E-Class E 350

    $34,039

    20,226 mi.
    Est. $640/mo

    Gettel Kia of Bradenton

    4.4
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    Bradenton, FL (1,039 mi)
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  • Black 2021 Mercedes-Benz E-Class E 350Black 2021 Mercedes-Benz E-Class E 350Black 2021 Mercedes-Benz E-Class E 350Black 2021 Mercedes-Benz E-Class E 350Black 2021 Mercedes-Benz E-Class E 350Black 2021 Mercedes-Benz E-Class E 350

    $29,985

    60,322 mi.
    Est. $564/mo

    Mercedes-Benz of Wesley Chapel

    4.2
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    Wesley Chapel, FL (992 mi)
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  • Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350Polar White 2021 Mercedes-Benz E-Class E 350

    $28,229

    $1.5K
    58,299 mi.
    Est. $531/mo

    Mercedes-Benz of Buckhead

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    Atlanta, GA (585 mi)

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  • White 2021 Mercedes-Benz E-Class E 350White 2021 Mercedes-Benz E-Class E 350White 2021 Mercedes-Benz E-Class E 350White 2021 Mercedes-Benz E-Class E 350White 2021 Mercedes-Benz E-Class E 350White 2021 Mercedes-Benz E-Class E 350

    $29,290

    32,029 mi.
    Est. $551/mo

    Lorenzo Nissan Ft Lauderdale

    4.6
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    Fort Lauderdale, FL (1,171 mi)
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  • Cirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2021 Mercedes-Benz E-Class E 350

    $32,881

    54,647 mi.
    Est. $618/mo

    Euro Motorcars Bethesda

    4.6
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    Bethesda, MD (589 mi)
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  • Black 2021 Mercedes-Benz E-Class RWD SedanBlack 2021 Mercedes-Benz E-Class RWD SedanBlack 2021 Mercedes-Benz E-Class RWD SedanBlack 2021 Mercedes-Benz E-Class RWD SedanBlack 2021 Mercedes-Benz E-Class RWD SedanBlack 2021 Mercedes-Benz E-Class RWD Sedan

    $32,215

    55,957 mi.
    Est. $606/mo

    Apple Lease Returns

    5.0
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    Austin, TX (971 mi)
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  • designo Diamond White Metallic 2021 Mercedes-Benz E-Class E 350designo Diamond White Metallic 2021 Mercedes-Benz E-Class E 350designo Diamond White Metallic 2021 Mercedes-Benz E-Class E 350designo Diamond White Metallic 2021 Mercedes-Benz E-Class E 350designo Diamond White Metallic 2021 Mercedes-Benz E-Class E 350designo Diamond White Metallic 2021 Mercedes-Benz E-Class E 350

    $30,253

    $536
    42,538 mi.
    Est. $569/mo

    Porsche South Orlando

    4.7
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    Orlando, FL (989 mi)
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  • Polar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATIC

    $33,697

    $300
    41,739 mi.
    Est. $633/mo

    Lexus of Mobile

    4.8
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    Mobile, AL (777 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $32,725

    $483
    57,742 mi.
    Est. $615/mo

    Mercedes-Benz of Springfield

    4.9
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    Chicopee, MA (774 mi)

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  • Blue 2021 Mercedes-Benz E-ClassBlue 2021 Mercedes-Benz E-ClassBlue 2021 Mercedes-Benz E-ClassBlue 2021 Mercedes-Benz E-ClassBlue 2021 Mercedes-Benz E-ClassBlue 2021 Mercedes-Benz E-Class

    $32,998

    33,103 mi.
    Est. $620/mo

    CarMax Hulen Mall

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    Fort Worth, TX (832 mi)
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  • Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350

    $33,840

    $100
    15,020 mi.
    Est. $636/mo

    Tropical Chevrolet

    4.1
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    Miami, FL (1,186 mi)
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  • BLACK 2021 Mercedes-Benz E-Class E350BLACK 2021 Mercedes-Benz E-Class E350BLACK 2021 Mercedes-Benz E-Class E350BLACK 2021 Mercedes-Benz E-Class E350BLACK 2021 Mercedes-Benz E-Class E350BLACK 2021 Mercedes-Benz E-Class E350

    $28,995

    61,724 mi.
    Est. $545/mo

    City Auto Sales, LLC Memphis

    4.4
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    Memphis, TN (479 mi)
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  • Lunar Blue 2021 Mercedes-Benz E-Class E 350Lunar Blue 2021 Mercedes-Benz E-Class E 350Lunar Blue 2021 Mercedes-Benz E-Class E 350Lunar Blue 2021 Mercedes-Benz E-Class E 350Lunar Blue 2021 Mercedes-Benz E-Class E 350Lunar Blue 2021 Mercedes-Benz E-Class E 350

    $34,990

    27,126 mi.
    Est. $658/mo

    Porsche Jacksonville

    4.9
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    Jacksonville, FL (869 mi)
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  • Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350Gray 2021 Mercedes-Benz E-Class E 350

    $31,699

    23,753 mi.
    Est. $596/mo

    LA City Cars

    4.0
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    Inglewood, CA (1,751 mi)
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  • Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 350

    $30,220

    51,568 mi.
    Est. $568/mo

    AutoNation Ford Katy

    4.4
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    Katy, TX (950 mi)

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  • Gray 2021 Mercedes-Benz E-Class RWD SedanGray 2021 Mercedes-Benz E-Class RWD SedanGray 2021 Mercedes-Benz E-Class RWD SedanGray 2021 Mercedes-Benz E-Class RWD SedanGray 2021 Mercedes-Benz E-Class RWD SedanGray 2021 Mercedes-Benz E-Class RWD Sedan

    $28,995

    86,166 mi.
    Est. $545/mo

    Car Gro

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    Los Angeles, CA (1,741 mi)
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  • White 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATIC

    $36,850

    22,126 mi.
    Est. $693/mo

    International Autohaus

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    Bellingham, WA (1,741 mi)
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  • Obsidian Black 2021 Mercedes-Benz E-Class E 350Obsidian Black 2021 Mercedes-Benz E-Class E 350Obsidian Black 2021 Mercedes-Benz E-Class E 350Obsidian Black 2021 Mercedes-Benz E-Class E 350Obsidian Black 2021 Mercedes-Benz E-Class E 350Obsidian Black 2021 Mercedes-Benz E-Class E 350

    $27,880

    $115
    78,821 mi.
    Est. $524/mo

    Volvo Cars Hilton Head

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    Bluffton, SC (762 mi)
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  • Graphite Gray 2021 Mercedes-Benz E-Class E 350Graphite Gray 2021 Mercedes-Benz E-Class E 350Graphite Gray 2021 Mercedes-Benz E-Class E 350Graphite Gray 2021 Mercedes-Benz E-Class E 350Graphite Gray 2021 Mercedes-Benz E-Class E 350Graphite Gray 2021 Mercedes-Benz E-Class E 350

    $29,880

    66,506 mi.
    Est. $562/mo

    Jaguar Land Rover Portland

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    Portland, OR (1,754 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2025 Mercedes-Benz E-Class E 350 $55,619 20 Great deals
2023 Mercedes-Benz E-Class E 350 $41,096 15 Great deals
2022 Mercedes-Benz E-Class E 350 $35,760 34 Great deals
2020 Mercedes-Benz E-Class E 350 $24,267 8 Great deals
2016 Mercedes-Benz E-Class E 350 $14,633 12 Great deals
2015 Mercedes-Benz E-Class E 350 $14,898 11 Great deals
2014 Mercedes-Benz E-Class E 350 $13,247 52 Great deals
2013 Mercedes-Benz E-Class E 350 $11,607 16 Great deals
2012 Mercedes-Benz E-Class E 350 $11,830 10 Great deals

About the 2021 Mercedes-Benz E-Class E 350

Basics

E 350 shown.

Seating
5
Door count
4
Drivetrain
Rear Wheel Drive
Combined MPG
25
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Mercedes-Benz E-Class E 350
FAQs

How much does the 2021 Mercedes-Benz E-Class E 350 cost?

The 2021 Mercedes-Benz E-Class E 350 price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class E 350 is $31,141, with pricing starting at $22,999.

What is the MPG of the 2021 Mercedes-Benz E-Class E 350?

The 2021 Mercedes-Benz E-Class E 350 offers up to 22 MPG in city driving and 31 MPG on the highway for a combined rating of 25 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz E-Class E 350?

The 2021 Mercedes-Benz E-Class E 350 compares to and/or competes against the following vehicles:


Is the 2021 Mercedes-Benz E-Class E 350 reliable?

The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.

Ratings (9 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Trims

E 350 (2 styles)

Style
E 350 RWD Sedan E 350 4MATIC Sedan
Inventory price
Starting at $54,250 Starting at $56,750
Combined MPG
25 25
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel) 255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
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Mercedes-Benz E-Class trims