2022
Mercedes-Benz GLS 450

Photo & video gallery






























The good & the bad
Available cars near you
-
9 mi away
-
$46,300 $488 price drop57 mi away
-
$61,596 $1,203 price drop65 mi away
-
$51,99869 mi away
-
$54,700 $1,300 price drop88 mi away
-
89 mi away
Factory warranties
New car program benefits
Certified Pre-Owned program benefits
Compare similar vehicles
-
2022Mercedes-Benz GLS 450Starts at$77,85018 City / 24 HwyMPG6Seat capacityIntercooled Turbo Gas/Electric I-6EngineAll-wheel driveDrivetrain
Compare -
2021Mercedes-Benz GLS 580Starts at$98,85016 City / 21 HwyMPG6Seat capacityTwin Turbo Gas/Electric V-8EngineAll-wheel driveDrivetrain
Compare -
2023BMW X7Starts at$77,85021 City / 25 HwyMPG6Seat capacityTwin Turbo Gas/Electric V-8EngineAll-wheel DriveDrivetrain
Compare -
2023Mercedes-Benz GLS 450Starts at$81,80018 City / 23 HwyMPG6Seat capacityIntercooled Turbo Gas/Electric I-6EngineAll-wheel driveDrivetrain
Compare
Most recent
-
I have a 2022 GLS 450 with lots of features.
I have a 2022 GLS 450 with lots of features...except reliability.This car has had 14 recalls. I had a terrifying experience of backing out of my driveway, the information screen going blank, the cars engine shut off, AND the brakes stopped working. We live on a steep driveway, and have a row of trees that stopped me...or I would- Does not recommend this car
-
Very happy with my purchase from RBM Alpharetta.
Very happy with my purchase from RBM Alpharetta. The car has a very comfortable interior with all the features available. Handles well in town and on long drives. Good acceleration for such a big vehicle. Love the contemporary exterior.- Does recommend this car
Latest news from cars.com

105,000 Mercedes-Benz GLE, GLS SUVs Recalled for Transmission Issue
Mercedes Adds 70,000 GLE, GLS SUVs to Detaching Window Trim Recall
Nearly 60,000 Mercedes SUVs Recalled for Seatback Lock Failure
Mercedes-Benz dealers near you
FAQ
What trim levels are available for the 2022 Mercedes-Benz GLS 450?
The 2022 Mercedes-Benz GLS 450 is available in 1 trim level:
- GLS 450 (1 style)
What is the MPG of the 2022 Mercedes-Benz GLS 450?
The 2022 Mercedes-Benz GLS 450 offers up to 18 MPG in city driving and 24 MPG on the highway. These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on vehicle options, trim level, driving conditions, driving habits, vehicle maintenance, and other factors.
What are some similar vehicles and competitors of the 2022 Mercedes-Benz GLS 450?
The 2022 Mercedes-Benz GLS 450 compares to and/or competes against the following vehicles:
Is the 2022 Mercedes-Benz GLS 450 reliable?
The 2022 Mercedes-Benz GLS 450 has an average reliability rating of 3.0 out of 5 according to cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 Mercedes-Benz GLS 450 owners.
Is the 2022 Mercedes-Benz GLS 450 a good SUV?
Below are the cars.com consumers ratings for the 2022 Mercedes-Benz GLS 450. 50.0% of drivers recommend this vehicle.
- Comfort: 4.0
- Interior: 4.0
- Performance: 3.0
- Value: 3.0
- Exterior: 4.5
- Reliability: 3.0
Mercedes-Benz GLS 450 history
-
2025 Mercedes-Benz GLS 450 -
2024 Mercedes-Benz GLS 450 -
2023 Mercedes-Benz GLS 450 -
2022 Mercedes-Benz GLS 450 -
2021 Mercedes-Benz GLS 450 -
2020 Mercedes-Benz GLS 450 -
2019 Mercedes-Benz GLS 450 -
2018 Mercedes-Benz GLS 450