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  • Polar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATIC

    $38,020

    40,323 mi.
    Est. $700/mo

    Mercedes-Benz of Easton

    4.9
    Check Availability
    Columbus, OH (9 mi)
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  • Silver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATIC

    $43,800

    $2.5K
    31,282 mi.
    Est. $806/mo

    Toy Barn

    4.2
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    Dublin, OH (12 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATIC

    $33,387

    56,797 mi.
    Est. $615/mo

    Crown Eurocars of Dublin

    5.0
    Dublin, OH (13 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATIC

    $39,977

    $494
    54,041 mi.
    Est. $736/mo

    Crown Eurocars of Dublin

    5.0
    Dublin, OH (13 mi)
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  • Gray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-Class

    $35,998

    $1K
    39,661 mi.
    Est. $663/mo

    CarMax Augusta

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    $399 delivery to Columbus, OH (9 mi)
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  • Red 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-Class

    $37,998

    26,815 mi.
    Est. $700/mo

    CarMax Birmingham

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    $499 delivery to Columbus, OH (9 mi)
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  • Mojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATIC

    $41,997

    13,521 mi.
    Est. $773/mo

    Mercedes-Benz of Indianapolis

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    Indianapolis, IN (165 mi)
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  • Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350

    $36,950

    30,276 mi.
    Est. $680/mo

    Fishers Imports NW

    4.6
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    Indianapolis, IN (172 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $41,880

    $1K
    12,893 mi.
    Est. $771/mo

    Mercedes-Benz of Pittsburgh

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    Pittsburgh, PA (165 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $31,799

    $900
    26,006 mi.
    Est. $586/mo

    North Coast Mitsubishi West Cleveland

    4.6
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    Cleveland, OH (122 mi)
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  • WHITE 2022 Mercedes-Benz E-Class 4MATICWHITE 2022 Mercedes-Benz E-Class 4MATICWHITE 2022 Mercedes-Benz E-Class 4MATICWHITE 2022 Mercedes-Benz E-Class 4MATICWHITE 2022 Mercedes-Benz E-Class 4MATICWHITE 2022 Mercedes-Benz E-Class 4MATIC

    $36,799

    60,077 mi.
    Est. $678/mo

    Empire Auto Collection

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    Warren, MI (173 mi)
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  • GREY 2022 Mercedes-Benz E-Class 4MATICGREY 2022 Mercedes-Benz E-Class 4MATICGREY 2022 Mercedes-Benz E-Class 4MATICGREY 2022 Mercedes-Benz E-Class 4MATICGREY 2022 Mercedes-Benz E-Class 4MATICGREY 2022 Mercedes-Benz E-Class 4MATIC

    $34,990

    39,621 mi.
    Est. $644/mo

    Empire Auto Collection

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    Warren, MI (173 mi)
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  • Polar White 2022 Mercedes-Benz E-ClassPolar White 2022 Mercedes-Benz E-ClassPolar White 2022 Mercedes-Benz E-Class

    $40,991

    27,857 mi.
    Est. $755/mo

    Bud Smail Motorcars, LTD

    4.9
    Greensburg, PA (188 mi)
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  • Cirrus Silver 2022 Mercedes-Benz E-Class E 350Cirrus Silver 2022 Mercedes-Benz E-Class E 350Cirrus Silver 2022 Mercedes-Benz E-Class E 350Cirrus Silver 2022 Mercedes-Benz E-Class E 350Cirrus Silver 2022 Mercedes-Benz E-Class E 350Cirrus Silver 2022 Mercedes-Benz E-Class E 350

    $35,000

    $500
    26,513 mi.
    Est. $644/mo

    Lebanon Ford

    4.8
    Check Availability
    Lebanon, OH (73 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class $74,861 30 Great deals
2025 Mercedes-Benz E-Class $62,386 45 Great deals
2024 Mercedes-Benz E-Class $55,675 39 Good deals
2023 Mercedes-Benz E-Class $43,210 40 Great deals
2021 Mercedes-Benz E-Class $31,578 8 Great deals
2020 Mercedes-Benz E-Class $25,861 14 Great deals
2019 Mercedes-Benz E-Class $23,320 29 Great deals
2018 Mercedes-Benz E-Class $20,478 23 Great deals
2017 Mercedes-Benz E-Class $17,966 21 Great deals

About the 2022 Mercedes-Benz E-Class

Basics

E 350 shown (base trim).

Seating
5
Door count
4
Drivetrain
Rear-wheel drive
Combined MPG
26
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Mercedes-Benz E-Class
FAQs

How much does the 2022 Mercedes-Benz E-Class cost?

The 2022 Mercedes-Benz E-Class price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class is $38,306, with pricing starting at $25,000.

What is the MPG of the 2022 Mercedes-Benz E-Class?

The 2022 Mercedes-Benz E-Class offers up to 23 MPG in city driving and 31 MPG on the highway for a combined rating of 26 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2022 Mercedes-Benz E-Class reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Is the 2022 Mercedes-Benz E-Class a good sedan?

Below are the Cars.com consumer ratings for the 2022 Mercedes-Benz E-Class.

(3 reviews)
Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 350 (2 styles)

Style
E 350 4MATIC Sedan E 350 RWD Sedan
Inventory price
Starting at $57,450 Starting at $54,950
Combined MPG
24 26
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel) 255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)

E 450 (6 styles)

Style
E 450 4MATIC Sedan E 450 4MATIC All-Terrain Wagon E 450 4MATIC Coupe E 450 RWD Coupe E 450 RWD Cabriolet E 450 4MATIC Cabriolet
Inventory price
Starting at $62,750 Starting at $68,400 Starting at $68,600 Starting at $66,100 Starting at $73,250 Starting at $75,750
Combined MPG
25 24 24 25 25 24
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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