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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $37,665

    19,979 mi.
    Est. $669/mo

    Northstar Kia

    4.5
    Woodside, NY (716 mi)
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  • White 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATIC

    $35,121

    $3.5K
    34,009 mi.
    Est. $624/mo

    Bill Kay Chevrolet

    4.6
    Lisle, IL (23 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATIC

    $37,617

    $771
    48,253 mi.
    Est. $668/mo

    Mercedes-Benz of Easton

    4.9
    Columbus, OH (277 mi)
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  • Nautical Blue 2022 Mercedes-Benz E-Class 4MATICNautical Blue 2022 Mercedes-Benz E-Class 4MATICNautical Blue 2022 Mercedes-Benz E-Class 4MATICNautical Blue 2022 Mercedes-Benz E-Class 4MATICNautical Blue 2022 Mercedes-Benz E-Class 4MATICNautical Blue 2022 Mercedes-Benz E-Class 4MATIC

    $39,990

    $1K
    41,469 mi.
    Est. $710/mo

    Mercedes-Benz of Arlington

    4.7
    Arlington, VA (592 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $42,815

    29,452 mi.
    Est. $760/mo

    Mercedes-Benz of Tysons Corner

    4.6
    Vienna, VA (584 mi)
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  • White 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATIC

    $38,009

    40,909 mi.
    Est. $675/mo

    International Autos

    4.2
    West Allis, WI (81 mi)
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  • Gray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATIC

    $28,995

    69,298 mi.
    Est. $515/mo

    Auto House of Bloomington

    4.2
    Bloomington, IL (121 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $36,097

    $200
    56,148 mi.
    Est. $641/mo

    Mercedes-Benz of Newton

    4.2
    Newton, NJ (670 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $34,998

    $1K
    43,959 mi.
    Est. $621/mo

    CarMax West 104th Ave

    4.3
    Federal Heights, CO (917 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $34,998

    $1K
    50,513 mi.
    Est. $621/mo

    CarMax Rivergate

    4.7
    Nashville, TN (389 mi)
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  • Gray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATIC

    $37,890

    $560
    23,149 mi.
    Est. $673/mo

    Sunrise Chevrolet

    4.0
    Queens, NY (721 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATIC

    $38,844

    37,001 mi.
    Est. $690/mo

    Genesis of Columbus

    Columbus, OH (276 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $43,932

    34,412 mi.
    Est. $780/mo

    RBM of Alpharetta

    5.0
    Alpharetta, GA (567 mi)
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  • Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATIC

    $36,998

    $2.4K
    23,174 mi.
    Est. $657/mo

    Coggin Honda Jacksonville

    4.7
    Jacksonville, FL (868 mi)
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  • MANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class 4MATIC

    $37,925

    38,652 mi.
    Est. $673/mo

    Mercedes-Benz of Buffalo

    4.8
    Williamsville, NY (463 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $32,687

    58,051 mi.
    Est. $580/mo

    Porsche Owings Mills

    5.0
    Owings Mills, MD (593 mi)
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  • MANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $38,089

    39,497 mi.
    Est. $676/mo

    CarShop Cranberry

    4.7
    Cranberry Twp, PA (399 mi)
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  • 2022 Mercedes-Benz E-Class E 350 4MATIC2022 Mercedes-Benz E-Class E 350 4MATIC2022 Mercedes-Benz E-Class E 350 4MATIC2022 Mercedes-Benz E-Class E 350 4MATIC2022 Mercedes-Benz E-Class E 350 4MATIC2022 Mercedes-Benz E-Class E 350 4MATIC

    $41,989

    24,441 mi.
    Est. $746/mo

    Mercedes-Benz of North Haven

    4.2
    North Haven, CT (764 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $38,689

    $400
    28,034 mi.
    Est. $687/mo

    CarShop - Robinson Township

    4.8
    Pittsburgh, PA (401 mi)
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  • Graphite Gray Metallic 2022 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class E 350 4MATICGraphite Gray Metallic 2022 Mercedes-Benz E-Class E 350 4MATIC

    $36,576

    56,784 mi.
    Est. $649/mo

    Grubbs Nissan of Tulsa

    3.4
    Tulsa, OK (595 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $38,217

    44,812 mi.
    Est. $679/mo

    Mercedes-Benz of Springfield

    4.9
    Chicopee, MA (774 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATIC

    $33,888

    $102
    27,114 mi.
    Est. $602/mo

    Quakertown Mitsubishi

    4.6
    Quakertown, PA (647 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $36,789

    $1.2K
    29,450 mi.
    Est. $653/mo

    BMW of Freehold

    4.8
    Freehold, NJ (704 mi)
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  • Graphite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2022 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $44,784

    14,435 mi.
    Est. $795/mo

    Mercedes-Benz of Morristown

    4.9
    Morristown, NJ (687 mi)
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  • Cirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $31,500

    35,173 mi.
    Est. $559/mo

    Prestige Auto Brokers

    Grand Prairie, TX (812 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 350 4MATIC 39 Great deals
2025 Mercedes-Benz E-Class E 350 4MATIC $57,330 11 Great deals
2024 Mercedes-Benz E-Class E 350 4MATIC $54,160 26 Great deals
2023 Mercedes-Benz E-Class E 350 4MATIC $42,058 9 Great deals
2021 Mercedes-Benz E-Class E 350 4MATIC $31,568 8 Great deals
2020 Mercedes-Benz E-Class E 350 4MATIC $26,948 13 Great deals
2016 Mercedes-Benz E-Class E 350 4MATIC $16,353 11 Great deals
2015 Mercedes-Benz E-Class E 350 4MATIC $14,164 5 Good deals
2014 Mercedes-Benz E-Class E 350 4MATIC $12,587 13 Great deals

About the 2022 Mercedes-Benz E-Class E 350 4MATIC

Basics

E 350 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
24
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Mercedes-Benz E-Class E 350 4MATIC
FAQs

How much does the 2022 Mercedes-Benz E-Class E 350 4MATIC cost?

The 2022 Mercedes-Benz E-Class E 350 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class E 350 4MATIC is $35,726, with pricing starting at $27,220.

What is the MPG of the 2022 Mercedes-Benz E-Class E 350 4MATIC?

The 2022 Mercedes-Benz E-Class E 350 4MATIC offers up to 21 MPG in city driving and 29 MPG on the highway for a combined rating of 24 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Mercedes-Benz E-Class E 350 4MATIC?

The 2022 Mercedes-Benz E-Class E 350 4MATIC compares to and/or competes against the following vehicles:


Is the 2022 Mercedes-Benz E-Class E 350 4MATIC reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 350 (1 style)

Style
E 350 4MATIC Sedan
Inventory price
Starting at $57,450
Combined MPG
24
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
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Mercedes-Benz E-Class trims