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  • Polar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATIC

    $28,900

    $1K
    76,750 mi.
    Est. $543/mo

    Mercedes-Benz of Wilmington

    3.7
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    Wilmington, DE (646 mi)

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  • White 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATIC

    $38,989

    34,009 mi.
    Est. $733/mo

    Bill Kay Chevrolet

    4.6
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    Lisle, IL (23 mi)

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  • Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATIC

    $39,720

    $253
    23,174 mi.
    Est. $747/mo

    Coggin Honda Jacksonville

    4.7
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    Jacksonville, FL (868 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $34,500

    $500
    60,647 mi.
    Est. $648/mo

    Mercedes-Benz of Catonsville

    4.3
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    Baltimore, MD (598 mi)
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  • Mojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $37,978

    22,818 mi.
    Est. $714/mo

    Performance Lexus Northern Kentucky

    4.6
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    Fort Wright, KY (254 mi)
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  • White 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATIC

    $33,498

    62,700 mi.
    Est. $630/mo

    Carvibe Houston

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    Houston, TX (949 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATIC

    $32,499

    75,007 mi.
    Est. $611/mo

    America's Xtreme Auto

    3.9
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    Houston, TX (944 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $37,048

    $400
    56,147 mi.
    Est. $696/mo

    Mercedes-Benz of Newton

    4.3
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    Newton, NJ (670 mi)

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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $39,984

    40,254 mi.
    Est. $752/mo

    RBM of Alpharetta

    5.0
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    Alpharetta, GA (567 mi)
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  • Red 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-ClassRed 2022 Mercedes-Benz E-Class

    $37,998

    $1K
    30,380 mi.
    Est. $714/mo

    CarMax Wilmington

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    Wilmington, NC (749 mi)
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  • Gray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATIC

    $40,998

    36,775 mi.
    Est. $771/mo

    The Highline Group

    4.5
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    Lowell, MA (833 mi)
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  • Cirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $31,500

    35,173 mi.
    Est. $592/mo

    Prestige Auto Brokers

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    Grand Prairie, TX (812 mi)
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  • Graphite Gray 2022 Mercedes-Benz E-Class 4MATICGraphite Gray 2022 Mercedes-Benz E-Class 4MATICGraphite Gray 2022 Mercedes-Benz E-Class 4MATICGraphite Gray 2022 Mercedes-Benz E-Class 4MATICGraphite Gray 2022 Mercedes-Benz E-Class 4MATICGraphite Gray 2022 Mercedes-Benz E-Class 4MATIC

    $36,880

    46,118 mi.
    Est. $693/mo

    Mercedes-Benz of Pittsburgh

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    Pittsburgh, PA (412 mi)
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  • MANUFAKTUR Cardinal Red 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Cardinal Red 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Cardinal Red 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Cardinal Red 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Cardinal Red 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Cardinal Red 2022 Mercedes-Benz E-Class 4MATIC

    $36,398

    34,675 mi.
    Est. $684/mo

    Mercedes-Benz of Hunt Valley

    4.6
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    Cockeysville, MD (600 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $34,777

    48,257 mi.
    Est. $654/mo

    European Auto Expo

    3.9
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    Lodi, NJ (706 mi)
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  • Obsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $35,342

    $189
    37,301 mi.
    Est. $664/mo

    BMW of Sarasota

    4.7
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    Sarasota, FL (1,051 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATIC

    $34,990

    $1K
    27,114 mi.
    Est. $658/mo

    Quakertown Mitsubishi

    4.5
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    Quakertown, PA (647 mi)
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  • Silver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATIC

    $32,995

    $2.7K
    48,503 mi.
    Est. $620/mo

    Maserati of Wilmington Pike

    4.3
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    Chadds Ford, PA (648 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $37,197

    $401
    29,435 mi.
    Est. $699/mo

    CarShop Glen Mills

    4.8
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    Glen Mills, PA (647 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $28,936

    $663
    65,827 mi.
    Est. $544/mo

    BMW of Ramsey

    4.3
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    Ramsey, NJ (701 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $37,594

    43,439 mi.
    Est. $707/mo

    Sears Imported Autos

    4.9
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    Minnetonka, MN (362 mi)
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  • Obsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $42,995

    21,879 mi.
    Est. $808/mo

    Mercedes-Benz of Arlington

    4.7
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    Arlington, VA (592 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $37,490

    19,979 mi.
    Est. $705/mo

    Northstar Kia

    4.5
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    Woodside, NY (716 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATIC

    $30,991

    70,752 mi.
    Est. $583/mo

    Watertown Mitsubishi

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    Watertown, CT (750 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $28,999

    $300
    26,006 mi.
    Est. $545/mo

    North Coast Mitsubishi West Cleveland

    4.6
    Check Availability
    Cleveland, OH (307 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 350 4MATIC 37 Great deals
2025 Mercedes-Benz E-Class E 350 4MATIC $57,280 13 Great deals
2024 Mercedes-Benz E-Class E 350 4MATIC $53,415 33 Great deals
2023 Mercedes-Benz E-Class E 350 4MATIC $42,748 23 Great deals
2021 Mercedes-Benz E-Class E 350 4MATIC $32,134 18 Great deals
2020 Mercedes-Benz E-Class E 350 4MATIC $26,560 14 Great deals
2016 Mercedes-Benz E-Class E 350 4MATIC $16,626 23 Great deals
2015 Mercedes-Benz E-Class E 350 4MATIC $13,901 11 Great deals
2014 Mercedes-Benz E-Class E 350 4MATIC $13,035 47 Great deals

About the 2022 Mercedes-Benz E-Class E 350 4MATIC

Basics

E 350 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
24
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Mercedes-Benz E-Class E 350 4MATIC
FAQs

How much does the 2022 Mercedes-Benz E-Class E 350 4MATIC cost?

The 2022 Mercedes-Benz E-Class E 350 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class E 350 4MATIC is $34,912, with pricing starting at $28,900.

What is the MPG of the 2022 Mercedes-Benz E-Class E 350 4MATIC?

The 2022 Mercedes-Benz E-Class E 350 4MATIC offers up to 21 MPG in city driving and 29 MPG on the highway for a combined rating of 24 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Mercedes-Benz E-Class E 350 4MATIC?

The 2022 Mercedes-Benz E-Class E 350 4MATIC compares to and/or competes against the following vehicles:


Is the 2022 Mercedes-Benz E-Class E 350 4MATIC reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 350 (1 style)

Style
E 350 4MATIC Sedan
Inventory price
Starting at $57,450
Combined MPG
24
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
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Mercedes-Benz E-Class trims