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  • MANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $40,376

    29,254 mi.
    Est. $761/mo

    Mercedes-Benz of Hoffman Estates

    4.6
    Hoffman Estates, IL (27 mi)
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  • Mojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATICMojave Silver Metallic 2022 Mercedes-Benz E-Class E 350 4MATIC

    $34,412

    $1K
    33,214 mi.
    Est. $648/mo

    Mac Haik Madison Chevrolet

    4.9
    Madison, MS (661 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATIC

    $37,698

    52,211 mi.
    Est. $710/mo

    BMW West Palm Beach

    4.9
    West Palm Beach, FL (1,133 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATIC

    $35,067

    $1.5K
    26,303 mi.
    Est. $661/mo

    Genesis of Suitland

    4.9
    Suitland, MD (602 mi)
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  • Silver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $31,126

    $100
    55,259 mi.
    Est. $586/mo

    Genesis of Plano

    4.2
    PLANO, TX (791 mi)
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  • MANUFAKTUR Selenite Grey Magno 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Selenite Grey Magno 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Selenite Grey Magno 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Selenite Grey Magno 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Selenite Grey Magno 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Selenite Grey Magno 2022 Mercedes-Benz E-Class 4MATIC

    $31,153

    $1K
    55,261 mi.
    Est. $587/mo

    Lexus of Orlando

    4.8
    Orlando, FL (990 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $37,998

    16,614 mi.
    Est. $716/mo

    CarMax Albany

    4.5
    Colonie, NY (707 mi)
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  • Silver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATICSilver 2022 Mercedes-Benz E-Class 4MATIC

    $36,998

    $645
    21,906 mi.
    Est. $697/mo

    Gravity Motor Cars

    Marietta, GA (575 mi)
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  • Polar White - 149 2022 Mercedes-Benz E-Class 4MATICPolar White - 149 2022 Mercedes-Benz E-Class 4MATICPolar White - 149 2022 Mercedes-Benz E-Class 4MATICPolar White - 149 2022 Mercedes-Benz E-Class 4MATICPolar White - 149 2022 Mercedes-Benz E-Class 4MATICPolar White - 149 2022 Mercedes-Benz E-Class 4MATIC

    $27,490

    67,460 mi.
    Est. $518/mo

    AutoProved

    3.5
    Allentown, PA (639 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $33,998

    53,141 mi.
    Est. $640/mo

    CarMax Oklahoma City

    4.8
    Oklahoma City, OK (685 mi)
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  • Gray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATICGray 2022 Mercedes-Benz E-Class E 350 4MATIC

    $34,607

    60,010 mi.
    Est. $652/mo

    Queen City Ford

    4.2
    Cincinnati, OH (250 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $29,524

    47,795 mi.
    Est. $556/mo

    Huntley Ford

    4.7
    Huntley, IL (45 mi)
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  • MANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $40,376

    29,254 mi.
    Est. $761/mo

    Mercedes-Benz of Hoffman Estates

    4.6
    Hoffman Estates, IL (27 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $29,987

    $500
    48,674 mi.
    Est. $565/mo

    Principle BMW of San Antonio

    4.6
    San Antonio, TX (1,047 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATICPolar White 2022 Mercedes-Benz E-Class E 350 4MATIC

    $40,428

    20,358 mi.
    Est. $762/mo

    Mercedes-Benz Of Henderson

    4.6
    Henderson, NV (1,519 mi)
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  • Cirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $36,299

    $450
    44,633 mi.
    Est. $684/mo

    Auto Collection of Murfreesboro

    Murfreesboro, TN (423 mi)
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  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $30,450

    $290
    27,555 mi.
    Est. $574/mo

    Honesdale Chrysler Dodge Jeep RAM

    4.9
    Honesdale, PA (639 mi)
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  • White 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATIC

    $31,900

    64,145 mi.
    Est. $601/mo

    Lowery Brothers Motors

    4.5
    Boaz, AL (538 mi)
    Check Availability
  • Black 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATICBlack 2022 Mercedes-Benz E-Class E 350 4MATIC

    $30,000

    $995
    55,930 mi.
    Est. $565/mo

    NOVA Autohaus

    Stafford, VA (590 mi)
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  • White 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATICWhite 2022 Mercedes-Benz E-Class 4MATIC

    $31,499

    $496
    54,718 mi.
    Est. $593/mo

    European Motors

    Plano, TX (792 mi)
    Check Availability
  • Gray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATICGray 2022 Mercedes-Benz E-Class 4MATIC

    $37,113

    30,288 mi.
    Est. $699/mo

    Carroll Cadillac of North Orlando

    3.3
    Sanford, FL (970 mi)
    Check Availability
  • Polar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATICPolar White 2022 Mercedes-Benz E-Class 4MATIC

    $33,875

    47,783 mi.
    Est. $638/mo

    Gravity Autos Sandy Springs

    3.1
    Sandy Springs, GA (576 mi)
    Check Availability
  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATICNautical Blue Metallic 2022 Mercedes-Benz E-Class E 350 4MATIC

    $37,790

    46,875 mi.
    Est. $712/mo

    Mercedes-Benz of Knoxville

    3.3
    Knoxville, TN (454 mi)
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  • White 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATICWhite 2022 Mercedes-Benz E-Class E 350 4MATIC

    $31,759

    $1K
    22,677 mi.
    Est. $598/mo

    Westchester Motors

    Yonkers, NY (717 mi)
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  • Black 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATICBlack 2022 Mercedes-Benz E-Class 4MATIC

    $35,998

    25,527 mi.
    Est. $678/mo

    Hi Line Motors

    2.7
    Plano, TX (791 mi)
    Check Availability

Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 350 4MATIC 80 Great deals
2025 Mercedes-Benz E-Class E 350 4MATIC $51,124 7 Great deals
2024 Mercedes-Benz E-Class E 350 4MATIC $50,538 41 Great deals
2023 Mercedes-Benz E-Class E 350 4MATIC $40,222 45 Great deals
2021 Mercedes-Benz E-Class E 350 4MATIC $30,043 14 Great deals
2020 Mercedes-Benz E-Class E 350 4MATIC $24,993 21 Great deals
2016 Mercedes-Benz E-Class E 350 4MATIC $15,338 12 Great deals
2015 Mercedes-Benz E-Class E 350 4MATIC $13,300 8 Great deals
2014 Mercedes-Benz E-Class E 350 4MATIC $12,333 32 Great deals

About the 2022 Mercedes-Benz E-Class E 350 4MATIC

Basics

E 350 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
24
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Mercedes-Benz E-Class E 350 4MATIC
FAQs

How much does the 2022 Mercedes-Benz E-Class E 350 4MATIC cost?

The 2022 Mercedes-Benz E-Class E 350 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class E 350 4MATIC is $33,182, with pricing starting at $27,490.

What is the MPG of the 2022 Mercedes-Benz E-Class E 350 4MATIC?

The 2022 Mercedes-Benz E-Class E 350 4MATIC offers up to 21 MPG in city driving and 29 MPG on the highway for a combined rating of 24 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Mercedes-Benz E-Class E 350 4MATIC?

The 2022 Mercedes-Benz E-Class E 350 4MATIC compares to and/or competes against the following vehicles:


Is the 2022 Mercedes-Benz E-Class E 350 4MATIC reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 350 (1 style)

Style
E 350 4MATIC Sedan
Inventory price
Starting at $57,450
Combined MPG
24
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)

2022 Mercedes-Benz E-Class trims