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  • Graphite Grey Met 2022 Mercedes-Benz E-Class E 350Graphite Grey Met 2022 Mercedes-Benz E-Class E 350Graphite Grey Met 2022 Mercedes-Benz E-Class E 350Graphite Grey Met 2022 Mercedes-Benz E-Class E 350Graphite Grey Met 2022 Mercedes-Benz E-Class E 350Graphite Grey Met 2022 Mercedes-Benz E-Class E 350

    $40,491

    39,622 mi.
    Est. $761/mo

    Mercedes-Benz of St. Charles

    4.6
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    Saint Charles, IL (37 mi)

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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $28,987

    $200
    59,458 mi.
    Est. $545/mo

    Mazda of Vacaville

    3.8
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    Vacaville, CA (1,817 mi)

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  • Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350

    $32,660

    41,453 mi.
    Est. $614/mo

    House of Imports

    4.6
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    Buena Park, CA (1,736 mi)
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  • Diamond 2022 Mercedes-Benz E-Class E 350Diamond 2022 Mercedes-Benz E-Class E 350Diamond 2022 Mercedes-Benz E-Class E 350Diamond 2022 Mercedes-Benz E-Class E 350Diamond 2022 Mercedes-Benz E-Class E 350Diamond 2022 Mercedes-Benz E-Class E 350

    $34,747

    $342
    51,406 mi.
    Est. $653/mo

    Mercedes-Benz of West Covina

    4.5
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    West Covina, CA (1,724 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $36,242

    $651
    28,062 mi.
    Est. $681/mo

    Mercedes-Benz of Laguna Niguel

    4.8
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    Laguna Niguel, CA (1,730 mi)
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  • Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 350Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 350Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 350Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 350Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 350Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 350

    $36,999

    $2K
    38,011 mi.
    Est. $695/mo

    Mercedes-Benz of Gainesville

    4.7
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    Gainesville, FL (894 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $35,950

    $5K
    29,632 mi.
    Est. $676/mo

    Mercedes-Benz of Coral Gables

    4.9
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    Coral Gables, FL (1,192 mi)
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  • Obsidian Black 2022 Mercedes-Benz E-Class E 350Obsidian Black 2022 Mercedes-Benz E-Class E 350Obsidian Black 2022 Mercedes-Benz E-Class E 350Obsidian Black 2022 Mercedes-Benz E-Class E 350Obsidian Black 2022 Mercedes-Benz E-Class E 350Obsidian Black 2022 Mercedes-Benz E-Class E 350

    $34,997

    $1.5K
    18,869 mi.
    Est. $658/mo

    Camelback Subaru

    4.5
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    Phoenix, AZ (1,449 mi)

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  • Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350

    $37,495

    $1.4K
    16,529 mi.
    Est. $705/mo

    Mercedes-Benz of Arlington

    4.7
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    Arlington, VA (592 mi)
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  • White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350

    $33,850

    $109
    30,386 mi.
    Est. $636/mo

    Mazda of Palm Beach

    4.6
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    North Palm Beach, FL (1,127 mi)
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  • Silver 2022 Mercedes-Benz E-Class E 350Silver 2022 Mercedes-Benz E-Class E 350Silver 2022 Mercedes-Benz E-Class E 350Silver 2022 Mercedes-Benz E-Class E 350Silver 2022 Mercedes-Benz E-Class E 350Silver 2022 Mercedes-Benz E-Class E 350

    $32,987

    45,210 mi.
    Est. $620/mo

    Bell Road Mitsubishi

    4.4
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    Phoenix, AZ (1,444 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $32,989

    $1.6K
    36,792 mi.
    Est. $620/mo

    BMW of Tallahassee

    4.9
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    Tallahassee, FL (811 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350

    $35,895

    $1K
    15,442 mi.
    Est. $675/mo

    Pedder Hyundai of Poway

    4.8
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    Poway, CA (1,717 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350

    $41,286

    12,189 mi.
    Est. $776/mo

    Mercedes-Benz of Lafayette

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    Lafayette, LA (847 mi)

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  • Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350

    $30,140

    64,084 mi.
    Est. $567/mo

    Rountree Moore Nissan

    4.2
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    Lake City, FL (854 mi)
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  • Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350

    $39,091

    $500
    12,608 mi.
    Est. $735/mo

    Metro Ford

    4.9
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    Miami, FL (1,186 mi)
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  • Silver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-Class

    $31,998

    $1K
    40,079 mi.
    Est. $601/mo

    CarMax Hulen Mall

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    Fort Worth, TX (832 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $33,976

    $3.6K
    51,856 mi.
    Est. $639/mo

    Porsche Sacramento

    4.9
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    Sacramento, CA (1,784 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350

    $36,911

    38,554 mi.
    Est. $694/mo

    AutoNation USA Austin

    4.1
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    Austin, TX (967 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $37,998

    17,218 mi.
    Est. $714/mo

    CarMax Scottsdale

    4.5
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    Scottsdale, AZ (1,437 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $38,998

    11,385 mi.
    Est. $733/mo

    CarMax Arlington/Ft. Worth

    4.7
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    Fort Worth, TX (819 mi)
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  • Blue 2022 Mercedes-Benz E-ClassBlue 2022 Mercedes-Benz E-ClassBlue 2022 Mercedes-Benz E-ClassBlue 2022 Mercedes-Benz E-ClassBlue 2022 Mercedes-Benz E-ClassBlue 2022 Mercedes-Benz E-Class

    $33,998

    $3K
    37,887 mi.
    Est. $639/mo

    CarMax Escondido

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    Escondido, CA (1,714 mi)
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  • Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350Gray 2022 Mercedes-Benz E-Class E 350

    $36,000

    30,276 mi.
    Est. $677/mo

    Fishers Imports NW

    4.6
    Check Availability
    Indianapolis, IN (154 mi)
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  • Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350

    $39,491

    15,628 mi.
    Est. $742/mo

    El Paso Honda

    4.5
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    El Paso, TX (1,244 mi)
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  • Silver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-Class

    $37,998

    $2K
    7,529 mi.
    Est. $714/mo

    CarMax Centennial

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    Las Vegas, NV (1,524 mi)
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  • Gray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-ClassGray 2022 Mercedes-Benz E-Class

    $33,998

    39,661 mi.
    Est. $639/mo

    CarMax Savannah

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    Savannah, GA (772 mi)
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  • White 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-ClassWhite 2022 Mercedes-Benz E-Class

    $34,998

    48,259 mi.
    Est. $658/mo

    CarMax Fresno

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    Fresno, CA (1,743 mi)
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  • Silver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-Class

    $34,998

    24,820 mi.
    Est. $658/mo

    CarMax Jacksonville West

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    Jacksonville, FL (871 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2025 Mercedes-Benz E-Class E 350 $55,603 19 Great deals
2023 Mercedes-Benz E-Class E 350 $41,096 15 Great deals
2021 Mercedes-Benz E-Class E 350 $31,457 18 Great deals
2020 Mercedes-Benz E-Class E 350 $24,349 8 Great deals
2016 Mercedes-Benz E-Class E 350 $14,546 12 Great deals
2015 Mercedes-Benz E-Class E 350 $14,898 11 Great deals
2014 Mercedes-Benz E-Class E 350 $13,228 51 Great deals
2013 Mercedes-Benz E-Class E 350 $11,607 16 Great deals
2012 Mercedes-Benz E-Class E 350 $11,708 10 Great deals

About the 2022 Mercedes-Benz E-Class E 350

Basics

E 350 shown.

Seating
5
Door count
4
Drivetrain
Rear Wheel Drive
Combined MPG
26
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Mercedes-Benz E-Class E 350
FAQs

How much does the 2022 Mercedes-Benz E-Class E 350 cost?

The 2022 Mercedes-Benz E-Class E 350 price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class E 350 is $35,023, with pricing starting at $25,477.

What is the MPG of the 2022 Mercedes-Benz E-Class E 350?

The 2022 Mercedes-Benz E-Class E 350 offers up to 23 MPG in city driving and 31 MPG on the highway for a combined rating of 26 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Mercedes-Benz E-Class E 350?

The 2022 Mercedes-Benz E-Class E 350 compares to and/or competes against the following vehicles:


Is the 2022 Mercedes-Benz E-Class E 350 reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 350 (1 style)

Style
E 350 RWD Sedan
Inventory price
Starting at $54,950
Combined MPG
26
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
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Mercedes-Benz E-Class trims