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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $37,576

    $230
    21,708 mi.
    Est. $667/mo

    Mercedes-Benz of Foothill Ranch

    4.8
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    Lake Forest, CA (1,725 mi)

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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $38,697

    $782
    14,542 mi.
    Est. $687/mo

    Lake Charles Toyota

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    Lake Charles, LA (865 mi)

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  • MANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class E 350MANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class E 350MANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class E 350MANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class E 350MANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class E 350MANUFAKTUR Diamond White 2022 Mercedes-Benz E-Class E 350

    $40,208

    28,390 mi.
    Est. $714/mo

    Mercedes-Benz of Georgetown

    4.8
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    Austin, TX (986 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $35,962

    $942
    29,003 mi.
    Est. $639/mo

    Mercedes-Benz of Wesley Chapel

    4.2
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    Wesley Chapel, FL (992 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350

    $35,798

    $200
    41,274 mi.
    Est. $636/mo

    Mercedes-Benz of The Woodlands

    5.0
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    The Woodlands, TX (917 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350

    $40,492

    8,163 mi.
    Est. $719/mo

    Mercedes-Benz of Coconut Creek

    4.3
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    Coral Springs, FL (1,158 mi)
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  • 2022 Mercedes-Benz E-Class E 3502022 Mercedes-Benz E-Class E 3502022 Mercedes-Benz E-Class E 3502022 Mercedes-Benz E-Class E 3502022 Mercedes-Benz E-Class E 3502022 Mercedes-Benz E-Class E 350

    $36,522

    $397
    42,423 mi.
    Est. $648/mo

    Covert Hutto

    4.0
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    Hutto, TX (958 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350

    $37,489

    27,820 mi.
    Est. $666/mo

    Mercedes-Benz of Miami

    4.3
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    Miami, FL (1,181 mi)

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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $35,987

    $4.5K
    27,369 mi.
    Est. $639/mo

    Mercedes-Benz Of Henderson

    4.6
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    Henderson, NV (1,519 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350

    $36,484

    35,537 mi.
    Est. $648/mo

    Audi South Orlando

    4.7
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    Orlando, FL (989 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $35,943

    $990
    27,861 mi.
    Est. $638/mo

    Brickell Buick & GMC

    4.4
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    Miami, FL (1,192 mi)
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  • Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350Polar White 2022 Mercedes-Benz E-Class E 350

    $29,334

    64,084 mi.
    Est. $521/mo

    Rountree Moore Nissan

    4.3
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    Lake City, FL (854 mi)
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  • Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350Graphite Gray 2022 Mercedes-Benz E-Class E 350

    $37,219

    $372
    12,608 mi.
    Est. $661/mo

    Metro Ford

    4.9
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    Miami, FL (1,186 mi)
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  • White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350White 2022 Mercedes-Benz E-Class E 350

    $34,576

    $607
    30,386 mi.
    Est. $614/mo

    Mazda of Palm Beach

    4.6
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    North Palm Beach, FL (1,127 mi)
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  • Graphite Gray Metallic 2022 Mercedes-Benz E-Class E 350Graphite Gray Metallic 2022 Mercedes-Benz E-Class E 350Graphite Gray Metallic 2022 Mercedes-Benz E-Class E 350Graphite Gray Metallic 2022 Mercedes-Benz E-Class E 350Graphite Gray Metallic 2022 Mercedes-Benz E-Class E 350Graphite Gray Metallic 2022 Mercedes-Benz E-Class E 350

    $34,850

    $440
    39,284 mi.
    Est. $619/mo

    Mullinax Ford of Mobile

    4.7
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    Mobile, AL (775 mi)
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  • Silver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATICSilver Metallic 2022 Mercedes-Benz E-Class 4MATIC

    $39,900

    31,357 mi.
    Est. $708/mo

    Mercedes-Benz Manhattan Inc.

    4.6
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    New York, NY (712 mi)
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  • Nautical Blue 2022 Mercedes-Benz E-Class E 350Nautical Blue 2022 Mercedes-Benz E-Class E 350Nautical Blue 2022 Mercedes-Benz E-Class E 350Nautical Blue 2022 Mercedes-Benz E-Class E 350Nautical Blue 2022 Mercedes-Benz E-Class E 350Nautical Blue 2022 Mercedes-Benz E-Class E 350

    $35,080

    $500
    12,465 mi.
    Est. $623/mo

    Volkswagen of Oakland

    4.8
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    Oakland, CA (1,846 mi)
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  • Blue 2022 Mercedes-Benz E-Class E 350Blue 2022 Mercedes-Benz E-Class E 350Blue 2022 Mercedes-Benz E-Class E 350Blue 2022 Mercedes-Benz E-Class E 350Blue 2022 Mercedes-Benz E-Class E 350Blue 2022 Mercedes-Benz E-Class E 350

    $32,698

    58,990 mi.
    Est. $581/mo

    Mark Mazda

    4.6
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    Scottsdale, AZ (1,441 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $31,988

    $632
    55,273 mi.
    Est. $568/mo

    Team Gillman Volkswagen of Kingwood

    4.3
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    Houston, TX (922 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $35,998

    24,982 mi.
    Est. $639/mo

    CarMax Canoga Park

    4.5
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    Canoga Park, CA (1,755 mi)
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  • Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 350

    $29,999

    $1.5K
    52,463 mi.
    Est. $533/mo

    Vista Motors

    4.2
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    Ontario, CA (1,713 mi)
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  • Silver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-ClassSilver 2022 Mercedes-Benz E-Class

    $37,998

    18,360 mi.
    Est. $675/mo

    CarMax Raleigh

    4.1
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    Raleigh, NC (633 mi)
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  • Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350Cirrus Silver Metallic 2022 Mercedes-Benz E-Class E 350

    $36,689

    30,913 mi.
    Est. $651/mo

    Mercedes-Benz of Stockton

    4.9
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    Stockton, CA (1,795 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $38,998

    17,204 mi.
    Est. $692/mo

    CarMax Jacksonville

    4.3
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    Jacksonville, FL (869 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $37,158

    $1.8K
    29,641 mi.
    Est. $660/mo

    St Pete Mitsubishi

    4.5
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    Seminole, FL (1,009 mi)
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  • Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350Black 2022 Mercedes-Benz E-Class E 350

    $40,077

    $203
    18,029 mi.
    Est. $712/mo

    Cadillac Lakeland

    4.7
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    Lakeland, FL (1,013 mi)
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  • Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350Nautical Blue Metallic 2022 Mercedes-Benz E-Class E 350

    $44,988

    2,869 mi.
    Est. $799/mo

    Sullivan Auto Trading

    4.6
    Check Availability
    Norfolk, VA (702 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2025 Mercedes-Benz E-Class E 350 $55,747 17 Great deals
2023 Mercedes-Benz E-Class E 350 $41,357 7 Great deals
2021 Mercedes-Benz E-Class E 350 $31,803 15 Great deals
2020 Mercedes-Benz E-Class E 350 $24,737 5 Great deals
2016 Mercedes-Benz E-Class E 350 $15,255 5 Great deals
2015 Mercedes-Benz E-Class E 350 $13,526 10 Good deals
2014 Mercedes-Benz E-Class E 350 $13,147 19 Great deals
2013 Mercedes-Benz E-Class E 350 $11,726 11 Good deals

About the 2022 Mercedes-Benz E-Class E 350

Basics

E 350 shown.

Seating
5
Door count
4
Drivetrain
Rear Wheel Drive
Combined MPG
26
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Mercedes-Benz E-Class E 350
FAQs

How much does the 2022 Mercedes-Benz E-Class E 350 cost?

The 2022 Mercedes-Benz E-Class E 350 price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class E 350 is $34,950, with pricing starting at $24,982.

What is the MPG of the 2022 Mercedes-Benz E-Class E 350?

The 2022 Mercedes-Benz E-Class E 350 offers up to 23 MPG in city driving and 31 MPG on the highway for a combined rating of 26 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Mercedes-Benz E-Class E 350?

The 2022 Mercedes-Benz E-Class E 350 compares to and/or competes against the following vehicles:


Is the 2022 Mercedes-Benz E-Class E 350 reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 350 (1 style)

Style
E 350 RWD Sedan
Inventory price
Starting at $54,950
Combined MPG
26
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
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Mercedes-Benz E-Class trims