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  • Obsidian 2021 Lexus RX 350 F SPORT AppearanceObsidian 2021 Lexus RX 350 F SPORT AppearanceObsidian 2021 Lexus RX 350 F SPORT AppearanceObsidian 2021 Lexus RX 350 F SPORT AppearanceObsidian 2021 Lexus RX 350 F SPORT AppearanceObsidian 2021 Lexus RX 350 F SPORT Appearance

    $30,494

    $505
    101,490 mi.
    Est. $530/mo

    Van Horn Ford of Oconomowoc

    4.7
    Check Availability
    Oconomowoc, WI (26 mi)

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  • White 2021 Lexus RX 350White 2021 Lexus RX 350White 2021 Lexus RX 350White 2021 Lexus RX 350White 2021 Lexus RX 350White 2021 Lexus RX 350

    $47,998

    12,908 mi.
    Est. $834/mo

    CarMax Grand Rapids (Kentwood)

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    $149 delivery to Milwaukee, WI (7 mi)
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  • Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350

    $40,998

    37,655 mi.
    Est. $712/mo

    CarMax Town Center

    4.2
    Check Availability
    $799 delivery to Milwaukee, WI (7 mi)
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  • Ultra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT Appearance

    $43,875

    $501
    22,513 mi.
    Est. $762/mo

    AutoNation Toyota Libertyville

    4.7
    Check Availability
    Libertyville, IL (56 mi)
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  • Black 2021 Lexus RX 350 F SPORT HandlingBlack 2021 Lexus RX 350 F SPORT HandlingBlack 2021 Lexus RX 350 F SPORT HandlingBlack 2021 Lexus RX 350 F SPORT HandlingBlack 2021 Lexus RX 350 F SPORT HandlingBlack 2021 Lexus RX 350 F SPORT Handling

    $43,408

    $1K
    36,743 mi.
    Est. $754/mo

    Woodfield Lexus

    4.8
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    Schaumburg, IL (71 mi)
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  • Matador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 Base

    $35,956

    61,665 mi.
    Est. $625/mo

    Driven Auto of Dundee

    4.0
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    East Dundee, IL (70 mi)
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  • Ultra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT Appearance

    $34,388

    51,725 mi.
    Est. $598/mo

    Car Smart of Madison

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    Madison, WI (70 mi)
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  • $45,372

    29,420 mi.
    Est. $788/mo

    Fields Lexus Glenview

    4.8
    Check Availability
    Glenview, IL (69 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $65,004

About the 2021 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Lexus RX 350
FAQs

How much does the 2021 Lexus RX 350 cost?

The 2021 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 RX 350 is $37,121, with pricing starting at $26,675.

What is the MPG of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2021 Lexus RX 350 reliable?

The 2021 Lexus RX 350 has an average reliability rating of 4.8 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 RX 350 owners.

Is the 2021 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2021 Lexus RX 350.

(63 reviews)
Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Ratings (63 reviews)

88% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Trims

RX 350 (2 styles)

Style
RX 350 AWD RX 350 FWD
Inventory price
Starting at $46,620 Starting at $45,220
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $48,700 Starting at $50,100
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling AWD RX 350 F SPORT Handling FWD
Inventory price
Starting at $52,500 Starting at $51,100
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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