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  • Eminent White Pearl 2021 Lexus RX 350 Base

    $43,990

    10,900 mi.
    Est. $762/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (11 mi)

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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $41,610

    20,030 mi.
    Est. $720/mo

    Sun Toyota

    4.7
    Check Availability
    Holiday, FL (15 mi)
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  • Caviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 Base

    $34,676

    $483
    42,230 mi.
    Est. $600/mo

    Karl Flammer Ford

    4.8
    Check Availability
    Tarpon Springs, FL (14 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $35,135

    $500
    52,857 mi.
    Est. $608/mo

    Chevrolet of Wesley Chapel

    4.6
    Check Availability
    Wesley Chapel, FL (11 mi)
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  • Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350

    $38,998

    35,387 mi.
    Est. $675/mo

    CarMax Tampa

    3.9
    Check Availability
    Tampa, FL (7 mi)
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  • Atomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 Premium

    $39,293

    $400
    52,448 mi.
    Est. $680/mo

    Lexus of Wesley Chapel

    4.9
    Check Availability
    Wesley Chapel, FL (11 mi)
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  • Nebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 Base

    $39,506

    $579
    43,897 mi.
    Est. $684/mo

    AutoNation Chevrolet South Clearwater

    4.4
    Check Availability
    Clearwater, FL (22 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $34,562

    69,256 mi.
    Est. $598/mo

    Sun Toyota

    4.7
    Check Availability
    Holiday, FL (15 mi)
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  • Ultra White 2021 Lexus RX 350 F SPORT Handling

    $41,459

    51,619 mi.
    Est. $718/mo

    Mercedes-Benz of Wesley Chapel

    4.2
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    Wesley Chapel, FL (9 mi)
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  • Moonbeam Beige Metallic 2021 Lexus RX 350 Premium

    $41,193

    35,991 mi.
    Est. $713/mo

    Lexus of Wesley Chapel

    4.9
    Check Availability
    Wesley Chapel, FL (11 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 Base

    $45,145

    12,406 mi.
    Est. $782/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (11 mi)
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  • Blue 2021 Lexus RX 350 L LuxuryBlue 2021 Lexus RX 350 L LuxuryBlue 2021 Lexus RX 350 L LuxuryBlue 2021 Lexus RX 350 L LuxuryBlue 2021 Lexus RX 350 L LuxuryBlue 2021 Lexus RX 350 L Luxury

    $52,998

    15,409 mi.
    Est. $918/mo

    CarMax Boynton Beach

    4.3
    Check Availability
    Free delivery to Tampa, FL (7 mi)
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  • White 2021 Lexus RX 350 F SPORT AppearanceWhite 2021 Lexus RX 350 F SPORT AppearanceWhite 2021 Lexus RX 350 F SPORT Appearance

    $41,915

    51,506 mi.
    Est. $726/mo

    Mossy of Picayune

    4.8
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    Free delivery from Picayune, MS (461 mi)
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  • Green Pearl 2021 Lexus RX 350 BaseGreen Pearl 2021 Lexus RX 350 BaseGreen Pearl 2021 Lexus RX 350 BaseGreen Pearl 2021 Lexus RX 350 BaseGreen Pearl 2021 Lexus RX 350 BaseGreen Pearl 2021 Lexus RX 350 Base

    $36,636

    $440
    52,828 mi.
    Est. $634/mo

    Kia of Leesburg

    4.5
    Check Availability
    Leesburg, FL (64 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $37,091

    31,277 mi.
    Est. $642/mo

    Audi Lakeland

    4.8
    Check Availability
    Lakeland, FL (34 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $32,993

    73,757 mi.
    Est. $571/mo

    Mazda Lakeland

    4.7
    Check Availability
    Lakeland, FL (40 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $28,526

    $763
    105,929 mi.
    Est. $494/mo

    Greenway Kia West

    4.3
    Check Availability
    Orlando, FL (73 mi)
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  • Ultra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT Handling

    $38,801

    $772
    58,729 mi.
    Est. $672/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (62 mi)
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  • Nebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 Base

    $37,082

    $439
    57,572 mi.
    Est. $642/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (62 mi)
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  • Atomic Silver 2021 Lexus RX 350 F SPORT HandlingAtomic Silver 2021 Lexus RX 350 F SPORT HandlingAtomic Silver 2021 Lexus RX 350 F SPORT HandlingAtomic Silver 2021 Lexus RX 350 F SPORT HandlingAtomic Silver 2021 Lexus RX 350 F SPORT HandlingAtomic Silver 2021 Lexus RX 350 F SPORT Handling

    $34,701

    $1K
    98,378 mi.
    Est. $601/mo

    Lexus of Orlando

    Check Availability
    Orlando, FL (69 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $42,190

    34,887 mi.
    Est. $730/mo

    Lexus of Orlando

    Check Availability
    Orlando, FL (69 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $32,083

    $1.2K
    83,534 mi.
    Est. $555/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (62 mi)
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  • Nightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 Base

    $37,201

    66,990 mi.
    Est. $644/mo

    Lexus of Orlando

    Check Availability
    Orlando, FL (69 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 Base

    $42,993

    33,945 mi.
    Est. $744/mo

    Mercedes-Benz of Sarasota

    4.5
    Check Availability
    SARASOTA, FL (62 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $64,195 1 Good deal
2025 Lexus RX 350 $54,584 7 Good deals
2024 Lexus RX 350 $50,379 27 Good deals
2023 Lexus RX 350 $47,392 7 Great deals
2022 Lexus RX 350 $38,949 5 Good deals
2020 Lexus RX 350 $34,696 6 Good deals

About the 2021 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Lexus RX 350
FAQs

How much does the 2021 Lexus RX 350 cost?

The 2021 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 RX 350 is $37,222, with pricing starting at $26,675.

What is the MPG of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 compares to and/or competes against the following vehicles:


Is the 2021 Lexus RX 350 reliable?

The 2021 Lexus RX 350 has an average reliability rating of 4.8 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 RX 350 owners.

Is the 2021 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2021 Lexus RX 350.

(63 reviews)
Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Ratings (63 reviews)

88% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Trims

RX 350 (2 styles)

Style
RX 350 AWD RX 350 FWD
Inventory price
Starting at $46,620 Starting at $45,220
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $48,700 Starting at $50,100
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling AWD RX 350 F SPORT Handling FWD
Inventory price
Starting at $52,500 Starting at $51,100
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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