Skip to main content
Best match Lowest price Highest price Lowest mileage Highest mileage Nearest location Best deal Newest year Oldest year Newest listed Oldest listed
Skip to Filters
  • Silver 2022 Lexus RX 350 F SPORT HandlingSilver 2022 Lexus RX 350 F SPORT HandlingSilver 2022 Lexus RX 350 F SPORT HandlingSilver 2022 Lexus RX 350 F SPORT HandlingSilver 2022 Lexus RX 350 F SPORT HandlingSilver 2022 Lexus RX 350 F SPORT Handling

    $45,808

    50,143 mi.
    Est. $786/mo

    Mercedes-Benz of West Chester Ohio

    Check Availability
    West Chester Township, OH (10 mi)
    Quick view
  • Gray Pearl 2022 Lexus RX 350 F SPORT HandlingGray Pearl 2022 Lexus RX 350 F SPORT HandlingGray Pearl 2022 Lexus RX 350 F SPORT HandlingGray Pearl 2022 Lexus RX 350 F SPORT HandlingGray Pearl 2022 Lexus RX 350 F SPORT HandlingGray Pearl 2022 Lexus RX 350 F SPORT Handling

    $50,298

    22,692 mi.
    Est. $863/mo

    Performance Lexus Northern Kentucky

    4.6
    Check Availability
    Fort Wright, KY (27 mi)
    Quick view
  • Grecian Water 2022 Lexus RX 350 F SPORT HandlingGrecian Water 2022 Lexus RX 350 F SPORT HandlingGrecian Water 2022 Lexus RX 350 F SPORT HandlingGrecian Water 2022 Lexus RX 350 F SPORT HandlingGrecian Water 2022 Lexus RX 350 F SPORT HandlingGrecian Water 2022 Lexus RX 350 F SPORT Handling

    $42,495

    61,865 mi.
    Est. $729/mo

    Joseph Toyota of Cincinnati

    4.4
    Check Availability
    Cincinnati, OH (19 mi)
    Quick view
  • Mica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 Base

    $45,671

    $440
    23,032 mi.
    Est. $783/mo

    Lexus of Dayton

    4.2
    Check Availability
    Dayton, OH (16 mi)
    Quick view
  • Caviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT Handling

    $49,834

    18,348 mi.
    Est. $855/mo

    Kernersville Chrysler Dodge Jeep RAM

    4.3
    Check Availability
    $1,584 delivery from Kernersville, NC (331 mi)
    Quick view
  • Silver 2022 Lexus RX 350 LSilver 2022 Lexus RX 350 LSilver 2022 Lexus RX 350 LSilver 2022 Lexus RX 350 LSilver 2022 Lexus RX 350 LSilver 2022 Lexus RX 350 L

    $39,998

    46,268 mi.
    Est. $686/mo

    CarMax Charlottesville

    Check Availability
    $349 delivery to Cincinnati, OH (13 mi)
    Quick view
  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $35,399

    $551
    76,338 mi.
    Est. $607/mo

    Lockhart Cadillac Fishers

    4.1
    Check Availability
    Fishers, IN (94 mi)
    Quick view
  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $41,560

    $759
    55,998 mi.
    Est. $713/mo

    Audi Dublin

    Check Availability
    Dublin, OH (80 mi)
    Quick view
  • Nightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 Base

    $41,750

    $1.2K
    61,045 mi.
    Est. $716/mo

    Tom Wood Lexus

    4.9
    Check Availability
    Indianapolis, IN (97 mi)
    Quick view
  • White Pearl 2022 Lexus RX 350 BaseWhite Pearl 2022 Lexus RX 350 BaseWhite Pearl 2022 Lexus RX 350 BaseWhite Pearl 2022 Lexus RX 350 BaseWhite Pearl 2022 Lexus RX 350 BaseWhite Pearl 2022 Lexus RX 350 Base

    $47,219

    14,413 mi.
    Est. $810/mo

    Neil Huffman Chevy GMC Nissan of Frankfo

    4.0
    Check Availability
    Frankfort, KY (91 mi)
    Quick view
  • Atomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT Handling

    $47,842

    45,233 mi.
    Est. $821/mo

    Germain Lexus of Easton

    4.8
    Check Availability
    Columbus, OH (89 mi)
    Quick view
  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $45,112

    $322
    38,573 mi.
    Est. $774/mo

    Neil Huffman Honda of Frankfort

    3.4
    Check Availability
    Frankfort, KY (91 mi)
    Quick view
  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $36,017

    $144
    64,268 mi.
    Est. $618/mo

    Genesis of Carmel

    3.1
    Check Availability
    INDIANAPOLIS, IN (97 mi)
    Quick view
  • White 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT AppearanceWhite 2022 Lexus RX 350 F SPORT Appearance

    $39,991

    48,409 mi.
    Est. $686/mo

    The Auto Loft

    Check Availability
    Columbus, OH (87 mi)
    Quick view
  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $37,791

    58,943 mi.
    Est. $648/mo

    Drive Direct

    4.3
    Check Availability
    Columbus, OH (87 mi)
    Quick view

Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $63,864 1 Good deal
2023 Lexus RX 350 $46,283 12 Good deals

About the 2022 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350
FAQs

How much does the 2022 Lexus RX 350 cost?

The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $41,377, with pricing starting at $27,447.

What is the MPG of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2022 Lexus RX 350 reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Is the 2022 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.

(13 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $49,400 Starting at $50,800
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling FWD RX 350 F SPORT Handling AWD
Inventory price
Starting at $51,800 Starting at $53,200
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Skip to Listings
Best match Lowest price Highest price Lowest mileage Highest mileage Nearest location Best deal Newest year Oldest year Newest listed Oldest listed