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  • Blue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATIC

    $51,141

    43,256 mi.
    Est. $949/mo

    Rallye Motors

    4.8
    Check Availability
    Roslyn, NY (20 mi)
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  • Green 2021 Mercedes-Benz E-Class E 450 4MATICGreen 2021 Mercedes-Benz E-Class E 450 4MATICGreen 2021 Mercedes-Benz E-Class E 450 4MATICGreen 2021 Mercedes-Benz E-Class E 450 4MATICGreen 2021 Mercedes-Benz E-Class E 450 4MATICGreen 2021 Mercedes-Benz E-Class E 450 4MATIC

    $33,794

    $3K
    40,903 mi.
    Est. $627/mo

    Car Revolution of Avenel

    3.2
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    Avenel, NJ (19 mi)
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  • Gray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATIC

    $42,411

    $288
    61,386 mi.
    Est. $787/mo

    Luxury Motor Cars

    1.4
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    Hillside, NJ (15 mi)
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  • White 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATIC

    $29,495

    56,211 mi.
    Est. $547/mo

    South Shore Mitsubishi

    3.2
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    Freeport, NY (21 mi)
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  • White 2021 Mercedes-Benz E-ClassWhite 2021 Mercedes-Benz E-ClassWhite 2021 Mercedes-Benz E-ClassWhite 2021 Mercedes-Benz E-ClassWhite 2021 Mercedes-Benz E-ClassWhite 2021 Mercedes-Benz E-Class

    $41,998

    $2K
    37,277 mi.
    Est. $780/mo

    CarMax Laurel

    3.4
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    $149 delivery to East Meadow, NY (22 mi)
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  • Red 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATIC

    $42,598

    75,680 mi.
    Est. $791/mo

    Maserati of Naperville

    3.6
    Check Availability
    $1,486 delivery from Naperville, IL (743 mi)
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  • Black 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATIC

    $40,198

    $496
    35,728 mi.
    Est. $746/mo

    Mercedes-Benz of Cherry Hill

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    Cherry Hill, NJ (76 mi)
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  • Graphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $39,985

    50,978 mi.
    Est. $742/mo

    Mercedes-Benz of Arlington

    4.7
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    Arlington, VA (208 mi)
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  • Graphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $39,791

    41,533 mi.
    Est. $739/mo

    Euro Motorcars Germantown

    4.1
    Check Availability
    Germantown, MD (203 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 450 4MATIC
2023 Mercedes-Benz E-Class E 450 4MATIC $47,975 15 Great deals

About the 2021 Mercedes-Benz E-Class E 450 4MATIC

Basics

E 450 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
26
Transmission
9-Speed A/T
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2021 Mercedes-Benz E-Class E 450 4MATIC
FAQs

How much does the 2021 Mercedes-Benz E-Class E 450 4MATIC cost?

The 2021 Mercedes-Benz E-Class E 450 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class E 450 4MATIC is $40,690, with pricing starting at $29,495.

What is the MPG of the 2021 Mercedes-Benz E-Class E 450 4MATIC?

The 2021 Mercedes-Benz E-Class E 450 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 26 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2021 Mercedes-Benz E-Class E 450 4MATIC reliable?

The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.

Ratings (9 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Trims

E 450 (3 styles)

Style
E 450 4MATIC Sedan E 450 4MATIC Cabriolet E 450 4MATIC All-Terrain Wagon
Inventory price
Starting at $62,000 Starting at $74,450 Starting at $67,600
Combined MPG
26 25 24
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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