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  • Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainLunar Blue Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainLunar Blue Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $46,990

    30,296 mi.
    Est. $883/mo

    Unlimited Motors

    4.5
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    Westfield, IN (148 mi)

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  • Red 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATIC

    $42,598

    $1.5K
    75,680 mi.
    Est. $801/mo

    Maserati of Naperville

    3.7
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    Naperville, IL (30 mi)

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  • Gray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATIC

    $39,664

    86,880 mi.
    Est. $746/mo

    ALM Gwinnett

    4.5
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    Duluth, GA (579 mi)
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  • Graphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $39,990

    $1.7K
    72,767 mi.
    Est. $752/mo

    Discovery Auto Center, LLC

    4.3
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    Tampa, FL (1,000 mi)
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  • Polar White 2021 Mercedes-Benz E-Class E 450Polar White 2021 Mercedes-Benz E-Class E 450Polar White 2021 Mercedes-Benz E-Class E 450Polar White 2021 Mercedes-Benz E-Class E 450Polar White 2021 Mercedes-Benz E-Class E 450Polar White 2021 Mercedes-Benz E-Class E 450

    $49,728

    $267
    43,644 mi.
    Est. $935/mo

    Land Rover Jacksonville

    4.7
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    Jacksonville, FL (869 mi)
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  • Graphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC

    $38,991

    70,700 mi.
    Est. $733/mo

    Mercedes-Benz of Beaumont

    4.5
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    Beaumont, TX (894 mi)
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  • Polar White 2021 Mercedes-Benz E-ClassPolar White 2021 Mercedes-Benz E-ClassPolar White 2021 Mercedes-Benz E-Class

    $45,981

    65,004 mi.
    Est. $864/mo

    Mercedes-Benz At Quirk Auto Park

    Bangor, ME (969 mi)
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  • Selenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC

    $48,081

    24,309 mi.
    Est. $904/mo

    Genesis of Downers Grove

    4.3
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    Downers Grove, IL (22 mi)
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  • BLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $42,000

    58,785 mi.
    Est. $789/mo

    Jacobs Mitsubishi

    4.0
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    New Port Richey, FL (981 mi)
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  • Cirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $37,680

    78,482 mi.
    Est. $708/mo

    Noblesville Imports

    4.8
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    Noblesville, IN (157 mi)
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  • Lunar Blue Metallic 2021 Mercedes-Benz E-Class E 63 AMG 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 63 AMG 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 63 AMG 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 63 AMG 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 63 AMG 4MATICLunar Blue Metallic 2021 Mercedes-Benz E-Class E 63 AMG 4MATIC

    $111,899

    21,065 mi.
    Est. $2,103/mo

    Blackdog Performance Cars

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    Lincolnshire, IL (26 mi)
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  • Gray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-Class

    $52,998

    31,606 mi.
    Est. $996/mo

    CarMax Texas Stadium (Irving)

    4.3
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    Irving, TX (805 mi)
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  • Polar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $44,706

    64,660 mi.
    Est. $840/mo

    Mercedes-Benz of Foothill Ranch

    4.8
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    Lake Forest, CA (1,725 mi)
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  • Obsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $44,620

    62,691 mi.
    Est. $839/mo

    McCarthy Blue Springs Hyundai

    3.1
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    Blue Springs, MO (402 mi)
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  • Black 2021 Mercedes-Benz E-Class E 63 AMG 4MATICBlack 2021 Mercedes-Benz E-Class E 63 AMG 4MATICBlack 2021 Mercedes-Benz E-Class E 63 AMG 4MATICBlack 2021 Mercedes-Benz E-Class E 63 AMG 4MATICBlack 2021 Mercedes-Benz E-Class E 63 AMG 4MATICBlack 2021 Mercedes-Benz E-Class E 63 AMG 4MATIC

    $97,999

    $1.9K
    35,196 mi.
    Est. $1,842/mo

    Gravity Autos Hollywood

    1.3
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    Hollywood, FL (1,176 mi)
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  • Obsidian Black Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $48,500

    $1K
    47,330 mi.
    Est. $912/mo

    USI Motors

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    Knoxville, TN (455 mi)
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  • Champagne 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $49,005

    64,014 mi.
    Est. $921/mo

    Northside Imports LLC

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    Pittsburgh, PA (405 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class $87,039 7 Good deals
2025 Mercedes-Benz E-Class $74,786 8 Great deals
2023 Mercedes-Benz E-Class $71,326 7 Great deals

About the 2021 Mercedes-Benz E-Class

Basics

E 350 shown (base trim).

Seating
5
Door count
4
Drivetrain
Rear-wheel drive
Combined MPG
25
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Mercedes-Benz E-Class
FAQs

How much does the 2021 Mercedes-Benz E-Class cost?

The 2021 Mercedes-Benz E-Class price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class is $36,103, with pricing starting at $22,999.

What is the MPG of the 2021 Mercedes-Benz E-Class?

The 2021 Mercedes-Benz E-Class offers up to 22 MPG in city driving and 31 MPG on the highway for a combined rating of 25 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2021 Mercedes-Benz E-Class reliable?

The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.

Is the 2021 Mercedes-Benz E-Class a good sedan?

Below are the Cars.com consumer ratings for the 2021 Mercedes-Benz E-Class.

(9 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Ratings (9 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Trims

E 350 (2 styles)

Style
E 350 RWD Sedan E 350 4MATIC Sedan
Inventory price
Starting at $54,250 Starting at $56,750
Combined MPG
25 25
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel) 255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)

E 450 (6 styles)

Style
E 450 4MATIC Coupe E 450 RWD Coupe E 450 4MATIC Sedan E 450 4MATIC Cabriolet E 450 4MATIC All-Terrain Wagon E 450 RWD Cabriolet
Inventory price
Starting at $67,450 Starting at $64,950 Starting at $62,000 Starting at $74,450 Starting at $67,600 Starting at $71,950
Combined MPG
25 26 26 25 24 25
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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