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  • Beige Metallic 2021 Lexus RX 350 BaseBeige Metallic 2021 Lexus RX 350 BaseBeige Metallic 2021 Lexus RX 350 BaseBeige Metallic 2021 Lexus RX 350 BaseBeige Metallic 2021 Lexus RX 350 BaseBeige Metallic 2021 Lexus RX 350 Base

    $34,412

    71,634 mi.
    Est. $625/mo

    Coconut Point Honda

    1.8
    Check Availability
    Estero, FL (16 mi)

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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $36,494

    46,277 mi.
    Est. $663/mo

    Mercedes-Benz of Bonita Springs

    4.9
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    Bonita Springs, FL (22 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $40,978

    $1K
    21,186 mi.
    Est. $744/mo

    Germain Lexus of Naples

    4.9
    Check Availability
    Naples, FL (23 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $35,888

    54,244 mi.
    Est. $652/mo

    Germain Lexus of Naples

    4.9
    Check Availability
    Naples, FL (23 mi)
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  • Gray Pearl 2021 Lexus RX 350 BaseGray Pearl 2021 Lexus RX 350 BaseGray Pearl 2021 Lexus RX 350 BaseGray Pearl 2021 Lexus RX 350 BaseGray Pearl 2021 Lexus RX 350 BaseGray Pearl 2021 Lexus RX 350 Base

    $34,597

    57,232 mi.
    Est. $628/mo

    Hyundai of Fort Myers

    4.3
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    Fort Myers, FL (11 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $38,888

    33,003 mi.
    Est. $706/mo

    Germain Lexus of Naples

    4.9
    Check Availability
    Naples, FL (23 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $45,698

    $300
    25,025 mi.
    Est. $830/mo

    Germain Lexus of Naples

    4.9
    Check Availability
    Naples, FL (23 mi)
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  • Nori Green Pearl 2021 Lexus RX 350 BaseNori Green Pearl 2021 Lexus RX 350 BaseNori Green Pearl 2021 Lexus RX 350 BaseNori Green Pearl 2021 Lexus RX 350 BaseNori Green Pearl 2021 Lexus RX 350 BaseNori Green Pearl 2021 Lexus RX 350 Base

    $39,998

    32,568 mi.
    Est. $726/mo

    Germain Lexus of Naples

    4.9
    Check Availability
    Naples, FL (23 mi)
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  • Nebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 Base

    $43,593

    24,423 mi.
    Est. $792/mo

    Lexus of Fort Myers

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    Fort Myers, FL (10 mi)
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  • $42,993

    28,036 mi.
    Est. $781/mo

    Lexus of Fort Myers

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    Fort Myers, FL (10 mi)
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  • Nightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 Base

    $35,964

    $525
    36,660 mi.
    Est. $653/mo

    Lexus of Palm Beach

    4.8
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    Free delivery from West Palm Beach, FL (118 mi)
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  • Gray 2021 Lexus RX 350Gray 2021 Lexus RX 350Gray 2021 Lexus RX 350Gray 2021 Lexus RX 350Gray 2021 Lexus RX 350Gray 2021 Lexus RX 350

    $38,998

    38,535 mi.
    Est. $708/mo

    CarMax Myrtle Beach

    4.7
    Check Availability
    $499 delivery to Fort Myers, FL (12 mi)
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  • Nebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 Base

    $36,778

    50,359 mi.
    Est. $668/mo

    Pompano Honda

    4.8
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    Pompano Beach, FL (121 mi)
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  • Ultra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT AppearanceUltra White 2021 Lexus RX 350 F SPORT Appearance

    $34,484

    53,685 mi.
    Est. $626/mo

    AutoNation Ford Margate

    4.7
    Check Availability
    Margate, FL (115 mi)
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  • Nebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 Base

    $36,498

    49,445 mi.
    Est. $663/mo

    AutoNation Toyota Weston

    4.7
    Check Availability
    Davie, FL (108 mi)
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  • Moonbeam Beige Metallic 2021 Lexus RX 350 BaseMoonbeam Beige Metallic 2021 Lexus RX 350 BaseMoonbeam Beige Metallic 2021 Lexus RX 350 BaseMoonbeam Beige Metallic 2021 Lexus RX 350 BaseMoonbeam Beige Metallic 2021 Lexus RX 350 BaseMoonbeam Beige Metallic 2021 Lexus RX 350 Base

    $37,691

    35,141 mi.
    Est. $684/mo

    King Hyundai

    4.4
    Check Availability
    Deerfield Beach, FL (121 mi)
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  • Obsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 Base

    $30,877

    70,263 mi.
    Est. $561/mo

    Toyota of Clermont

    4.9
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    Clermont, FL (140 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $22,500

    122,222 mi.
    Est. $409/mo

    Jacobs Mitsubishi Wesley Chapel

    4.5
    Check Availability
    Wesley Chapel, FL (118 mi)
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  • Ultra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT Handling

    $40,984

    58,729 mi.
    Est. $744/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (57 mi)
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  • Nebula Gray Pearl 2021 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2021 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2021 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2021 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2021 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2021 Lexus RX 350 F SPORT Handling

    $40,011

    58,646 mi.
    Est. $726/mo

    Lexus of Orlando

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    Orlando, FL (138 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $41,990

    31,271 mi.
    Est. $762/mo

    Audi Lakeland

    4.7
    Check Availability
    Lakeland, FL (106 mi)
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  • Caviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 Base

    $30,722

    $289
    84,754 mi.
    Est. $558/mo

    Lexus of Orlando

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    Orlando, FL (138 mi)
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  • Caviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 Base

    $36,173

    $863
    42,230 mi.
    Est. $657/mo

    Karl Flammer Ford

    4.8
    Check Availability
    Tarpon Springs, FL (120 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $38,031

    30,318 mi.
    Est. $691/mo

    AutoLenders Palm Harbor

    4.8
    Check Availability
    Palm Harbor, FL (114 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $59,824 4 Good deals
2025 Lexus RX 350 $54,135 14 Good deals
2024 Lexus RX 350 $52,277 6 Great deals
2023 Lexus RX 350 $48,058 21 Good deals
2022 Lexus RX 350 $43,120 7 Good deals

About the 2021 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Lexus RX 350
FAQs

How much does the 2021 Lexus RX 350 cost?

The 2021 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 RX 350 is $36,735, with pricing starting at $22,500.

What is the MPG of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 compares to and/or competes against the following vehicles:


Is the 2021 Lexus RX 350 reliable?

The 2021 Lexus RX 350 has an average reliability rating of 4.8 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 RX 350 owners.

Is the 2021 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2021 Lexus RX 350.

(63 reviews)
Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Ratings (63 reviews)

88% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Trims

RX 350 (2 styles)

Style
RX 350 AWD RX 350 FWD
Inventory price
Starting at $46,620 Starting at $45,220
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $48,700 Starting at $50,100
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling AWD RX 350 F SPORT Handling FWD
Inventory price
Starting at $52,500 Starting at $51,100
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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