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  • Satin Cashmere Metallic 2017 Lexus RX 350 BaseSatin Cashmere Metallic 2017 Lexus RX 350 BaseSatin Cashmere Metallic 2017 Lexus RX 350 BaseSatin Cashmere Metallic 2017 Lexus RX 350 BaseSatin Cashmere Metallic 2017 Lexus RX 350 BaseSatin Cashmere Metallic 2017 Lexus RX 350 Base

    $24,919

    $666
    92,837 mi.
    Est. $429/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (23 mi)

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  • Caviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 Base

    $34,676

    $483
    42,230 mi.
    Est. $598/mo

    Karl Flammer Ford

    4.8
    Check Availability
    Tarpon Springs, FL (25 mi)

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  • Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350Blue 2021 Lexus RX 350

    $38,998

    35,387 mi.
    Est. $672/mo

    CarMax Tampa

    3.9
    Check Availability
    Tampa, FL (29 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $44,229

    $916
    12,406 mi.
    Est. $762/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (23 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $41,610

    20,030 mi.
    Est. $717/mo

    Sun Toyota

    4.7
    Check Availability
    Holiday, FL (29 mi)
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  • Nebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 Base

    $39,281

    $225
    43,897 mi.
    Est. $677/mo

    AutoNation Chevrolet South Clearwater

    4.4
    Check Availability
    Clearwater, FL (9 mi)
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  • Nori Green Pearl 2021 Lexus RX 350 Base

    $35,891

    $594
    62,112 mi.
    Est. $618/mo

    Lexus of Clearwater

    4.8
    Check Availability
    Clearwater, FL (16 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 Base

    $40,849

    43,673 mi.
    Est. $704/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (23 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 Base

    $39,255

    53,935 mi.
    Est. $676/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (23 mi)
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  • $41,459

    51,619 mi.
    Est. $714/mo

    Lexus of Tampa Bay

    4.5
    Check Availability
    Tampa, FL (23 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 Base

    $34,562

    69,256 mi.
    Est. $596/mo

    Sun Toyota

    4.7
    Check Availability
    Holiday, FL (29 mi)
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  • White 2021 Lexus RX 350 F SPORT AppearanceWhite 2021 Lexus RX 350 F SPORT AppearanceWhite 2021 Lexus RX 350 F SPORT AppearanceWhite 2021 Lexus RX 350 F SPORT AppearanceWhite 2021 Lexus RX 350 F SPORT AppearanceWhite 2021 Lexus RX 350 F SPORT Appearance

    $41,915

    51,525 mi.
    Est. $722/mo

    Mossy of Picayune

    4.8
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    Free delivery from Picayune, MS (455 mi)
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  • Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350

    $34,998

    72,632 mi.
    Est. $603/mo

    CarMax Dothan

    Check Availability
    $199 delivery to Clearwater, FL (10 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $38,323

    43,775 mi.
    Est. $660/mo

    Jaguar Land Rover Sarasota

    4.6
    Check Availability
    Sarasota, FL (42 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $34,835

    $300
    52,857 mi.
    Est. $600/mo

    Chevrolet of Wesley Chapel

    4.6
    Check Availability
    Wesley Chapel, FL (40 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $41,264

    $1.7K
    33,945 mi.
    Est. $711/mo

    Mercedes-Benz of Sarasota

    4.5
    Check Availability
    SARASOTA, FL (42 mi)
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  • Ultra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT Handling

    $38,083

    $1.4K
    58,729 mi.
    Est. $656/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (42 mi)
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  • Atomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 Premium

    $38,944

    $349
    52,448 mi.
    Est. $671/mo

    Lexus of Wesley Chapel

    4.9
    Check Availability
    Wesley Chapel, FL (41 mi)
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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $31,526

    $557
    83,534 mi.
    Est. $543/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (42 mi)
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  • Nebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 BaseNebula Gray Pearl 2021 Lexus RX 350 Base

    $36,526

    $556
    57,572 mi.
    Est. $629/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (42 mi)
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  • Moonbeam Beige Metallic 2021 Lexus RX 350 PremiumMoonbeam Beige Metallic 2021 Lexus RX 350 PremiumMoonbeam Beige Metallic 2021 Lexus RX 350 PremiumMoonbeam Beige Metallic 2021 Lexus RX 350 PremiumMoonbeam Beige Metallic 2021 Lexus RX 350 PremiumMoonbeam Beige Metallic 2021 Lexus RX 350 Premium

    $41,193

    35,992 mi.
    Est. $710/mo

    Lexus of Wesley Chapel

    4.9
    Check Availability
    Wesley Chapel, FL (41 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $64,578 1 Good deal
2024 Lexus RX 350 $49,138 18 Good deals
2023 Lexus RX 350 $47,043 8 Great deals

About the 2021 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Lexus RX 350
FAQs

How much does the 2021 Lexus RX 350 cost?

The 2021 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 RX 350 is $37,034, with pricing starting at $26,525.

What is the MPG of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 compares to and/or competes against the following vehicles:


  • Toyota Highlander
  • Lexus RX 350h
  • Lexus RX 350L
  • Genesis GV70
  • Acura RDX
  • Acura MDX

Is the 2021 Lexus RX 350 reliable?

The 2021 Lexus RX 350 has an average reliability rating of 4.8 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 RX 350 owners.

Is the 2021 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2021 Lexus RX 350.

(63 reviews)
Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Ratings (63 reviews)

88% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Trims

RX 350 (2 styles)

Style
RX 350 AWD RX 350 FWD
Inventory price
Starting at $46,620 Starting at $45,220
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $48,700 Starting at $50,100
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling AWD RX 350 F SPORT Handling FWD
Inventory price
Starting at $52,500 Starting at $51,100
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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