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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $38,499

    $398
    33,916 mi.
    Est. $696/mo

    Naples Chrysler Dodge Jeep Ram

    4.6
    Check Availability
    Naples, FL (7 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $47,993

    58,609 mi.
    Est. $867/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (28 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $46,993

    38,208 mi.
    Est. $849/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (28 mi)
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  • Atomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT Handling

    $42,993

    63,269 mi.
    Est. $777/mo

    Lexus of Fort Myers

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    Fort Myers, FL (28 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $42,388

    $600
    17,657 mi.
    Est. $766/mo

    Germain Lexus of Naples

    4.9
    Check Availability
    Naples, FL (11 mi)
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  • Ultra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT Handling

    $47,493

    $500
    33,373 mi.
    Est. $858/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (28 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $44,993

    $500
    32,340 mi.
    Est. $813/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (28 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $41,478

    $1.5K
    48,298 mi.
    Est. $750/mo

    Germain Lexus of Naples

    4.9
    Check Availability
    Naples, FL (11 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $44,593

    $400
    42,680 mi.
    Est. $806/mo

    Lexus of Fort Myers

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    Fort Myers, FL (28 mi)
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  • Caviar 2022 Lexus RX 350 Base

    $47,993

    32,250 mi.
    Est. $867/mo

    Lexus of Fort Myers

    Check Availability
    Fort Myers, FL (28 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $44,998

    23,835 mi.
    Est. $813/mo

    Lexus of Palm Beach

    4.8
    Check Availability
    Free delivery from West Palm Beach, FL (111 mi)
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  • Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350

    $39,998

    50,181 mi.
    Est. $723/mo

    CarMax Kenner

    Check Availability
    $299 delivery to Naples, FL (3 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $39,079

    40,732 mi.
    Est. $706/mo

    Honda of Fort Myers

    4.2
    Check Availability
    Fort Myers, FL (32 mi)
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  • Gray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 Base

    $35,139

    60,854 mi.
    Est. $635/mo

    Bella Nissan of Venice

    4.8
    Check Availability
    Venice, FL (77 mi)
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  • Green Pearl 2022 Lexus RX 350 BaseGreen Pearl 2022 Lexus RX 350 BaseGreen Pearl 2022 Lexus RX 350 BaseGreen Pearl 2022 Lexus RX 350 BaseGreen Pearl 2022 Lexus RX 350 BaseGreen Pearl 2022 Lexus RX 350 Base

    $41,488

    39,528 mi.
    Est. $750/mo

    Bomnin Chevrolet Dadeland

    4.8
    Check Availability
    Miami, FL (98 mi)
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  • Blue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 LBlue 2022 Lexus RX 350 L

    $40,998

    36,761 mi.
    Est. $741/mo

    CarMax Miami (International Mall)

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    Doral, FL (93 mi)
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  • Mica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 BaseMica 2022 Lexus RX 350 Base

    $44,552

    45,385 mi.
    Est. $805/mo

    Lexus of Sarasota

    4.7
    Check Availability
    Sarasota, FL (89 mi)
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  • Ultra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT Handling

    $38,488

    49,435 mi.
    Est. $696/mo

    Bomnin Chevrolet West Kendall

    4.9
    Check Availability
    Miami, FL (95 mi)
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  • Red 2022 Lexus RX 350Red 2022 Lexus RX 350Red 2022 Lexus RX 350Red 2022 Lexus RX 350Red 2022 Lexus RX 350Red 2022 Lexus RX 350

    $32,998

    $5K
    58,441 mi.
    Est. $596/mo

    CarMax Ft. Lauderdale

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    Davie, FL (97 mi)
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  • Caviar 2022 Lexus RX 350 Base

    $32,942

    92,573 mi.
    Est. $595/mo

    AutoNation USA Fort Myers

    4.4
    Check Availability
    Fort Myers, FL (32 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $59,824 4 Good deals
2025 Lexus RX 350 $54,856 12 Good deals
2024 Lexus RX 350 $52,228 5 Great deals
2023 Lexus RX 350 $48,302 17 Good deals

About the 2022 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350
FAQs

How much does the 2022 Lexus RX 350 cost?

The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $41,239, with pricing starting at $27,790.

What is the MPG of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 compares to and/or competes against the following vehicles:


Is the 2022 Lexus RX 350 reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Is the 2022 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.

(13 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $49,400 Starting at $50,800
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling FWD RX 350 F SPORT Handling AWD
Inventory price
Starting at $51,800 Starting at $53,200
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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