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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $43,220

    33,122 mi.
    Est. $798/mo

    Lexus Clear Lake

    4.8
    Check Availability
    Friendswood, TX (8 mi)
    Quick view
  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $41,220

    56,989 mi.
    Est. $761/mo

    Lexus Clear Lake

    4.8
    Check Availability
    Friendswood, TX (8 mi)
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  • Red 2022 Lexus RX 350Red 2022 Lexus RX 350Red 2022 Lexus RX 350Red 2022 Lexus RX 350Red 2022 Lexus RX 350Red 2022 Lexus RX 350

    $41,998

    36,021 mi.
    Est. $775/mo

    CarMax North Houston

    4.6
    Check Availability
    Houston, TX (29 mi)
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  • Nightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 Base

    $41,991

    26,002 mi.
    Est. $775/mo

    ABZ Motors

    4.3
    Check Availability
    Houston, TX (24 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $34,806

    97,795 mi.
    Est. $642/mo

    Group 1 Toyota Southwest Houston

    4.2
    Check Availability
    Houston, TX (24 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $39,220

    66,666 mi.
    Est. $724/mo

    Lexus Clear Lake

    4.8
    Check Availability
    Friendswood, TX (8 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $31,220

    $500
    84,811 mi.
    Est. $576/mo

    Auto Boutique Texas

    3.6
    Check Availability
    Alvin, TX (8 mi)
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  • $45,220

    21,226 mi.
    Est. $835/mo

    Lexus Clear Lake

    4.8
    Check Availability
    Friendswood, TX (8 mi)
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  • $40,220

    72,630 mi.
    Est. $742/mo

    Lexus Clear Lake

    4.8
    Check Availability
    Friendswood, TX (8 mi)
    Quick view
  • Ultra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT Handling

    $47,116

    35,115 mi.
    Est. $870/mo

    BMW of Arlington

    4.6
    Check Availability
    $399 delivery from Arlington, TX (244 mi)

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  • White 2022 Lexus RX 350White 2022 Lexus RX 350White 2022 Lexus RX 350White 2022 Lexus RX 350White 2022 Lexus RX 350White 2022 Lexus RX 350

    $43,998

    $1K
    27,001 mi.
    Est. $812/mo

    CarMax Fort Bend

    4.4
    Check Availability
    Free delivery to Houston, TX (6 mi)

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  • Nori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 Base

    $33,737

    $739
    85,374 mi.
    Est. $623/mo

    Mercedes-Benz of Houston North

    4.5
    Check Availability
    Houston, TX (30 mi)
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  • Black 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT Handling

    $30,221

    $2K
    104,719 mi.
    Est. $558/mo

    BMW of West Houston

    4.8
    Check Availability
    Katy, TX (37 mi)
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  • Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350

    $31,998

    96,232 mi.
    Est. $591/mo

    CarMax Cy-Fair

    4.4
    Check Availability
    Houston, TX (33 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $42,885

    43,293 mi.
    Est. $791/mo

    THIScar

    4.7
    Check Availability
    Tomball, TX (39 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $42,325

    38,900 mi.
    Est. $781/mo

    Shottenkirk Nissan Katy

    4.8
    Check Availability
    Katy, TX (41 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $41,810

    $171
    36,709 mi.
    Est. $772/mo

    Shottenkirk Nissan Katy

    4.8
    Check Availability
    Katy, TX (41 mi)
    Quick view
  • Matador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT HandlingMatador Red Mica 2022 Lexus RX 350 F SPORT Handling

    $48,296

    $604
    25,535 mi.
    Est. $891/mo

    Northside Lexus

    4.9
    Check Availability
    Spring, TX (36 mi)
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  • Caviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT Handling

    $46,885

    $779
    38,042 mi.
    Est. $865/mo

    Northside Lexus

    4.9
    Check Availability
    Spring, TX (36 mi)
    Quick view
  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $40,495

    45,323 mi.
    Est. $747/mo

    Brookshire Hyundai

    Check Availability
    Brookshire, TX (50 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 Base

    $35,321

    94,122 mi.
    Est. $652/mo

    Northside Lexus

    4.9
    Check Availability
    Spring, TX (36 mi)
    Quick view
  • White 2022 Lexus RX 350 F SPORT Handling

    $52,400

    14,631 mi.
    Est. $967/mo

    Northside Lexus

    4.9
    Check Availability
    Spring, TX (36 mi)
    Quick view
  • Nightfall Mica 2022 Lexus RX 350 Base

    Not Priced

    110,947 mi.
    Est. $0/mo

    Northside Lexus

    4.9
    Check Availability
    Spring, TX (36 mi)
    Quick view

Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $63,379 2 Good deals
2025 Lexus RX 350 $56,187 7 Good deals
2024 Lexus RX 350 $51,851 13 Good deals
2023 Lexus RX 350 $49,472 6 Great deals
2017 Lexus RX 350 $25,572 4 Good deals

About the 2022 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350
FAQs

How much does the 2022 Lexus RX 350 cost?

The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $41,419, with pricing starting at $27,694.

What is the MPG of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2022 Lexus RX 350 reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Is the 2022 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.

(13 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $49,400 Starting at $50,800
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling FWD RX 350 F SPORT Handling AWD
Inventory price
Starting at $51,800 Starting at $53,200
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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