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  • Ultra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT Handling

    $42,325

    56,340 mi.
    Est. $781/mo

    BMW of Houston North

    4.7
    Check Availability
    Houston, TX (17 mi)

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  • Nebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT HandlingNebula Gray Pearl 2022 Lexus RX 350 F SPORT Handling

    $49,900

    22,004 mi.
    Est. $921/mo

    Northside Lexus

    4.9
    Check Availability
    Spring, TX (23 mi)
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  • Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350

    $39,998

    36,765 mi.
    Est. $738/mo

    CarMax Houston Katy Freeway

    4.6
    Check Availability
    Katy, TX (23 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $43,991

    30,620 mi.
    Est. $812/mo

    Audi North Houston

    4.6
    Check Availability
    Houston, TX (17 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $38,995

    66,666 mi.
    Est. $720/mo

    Lexus Clear Lake

    4.8
    Check Availability
    Friendswood, TX (21 mi)
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  • Caviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT HandlingCaviar 2022 Lexus RX 350 F SPORT Handling

    $41,996

    $1.8K
    39,662 mi.
    Est. $775/mo

    EchoPark Automotive Houston

    4.6
    Check Availability
    Houston, TX (7 mi)
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  • Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350Gray 2022 Lexus RX 350

    $29,998

    96,232 mi.
    Est. $554/mo

    CarMax Cy-Fair

    4.5
    Check Availability
    Houston, TX (17 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $42,201

    $293
    36,709 mi.
    Est. $779/mo

    Shottenkirk Nissan Katy

    4.8
    Check Availability
    Katy, TX (28 mi)
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  • Nori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 BaseNori Green Pearl 2022 Lexus RX 350 Base

    $35,874

    85,374 mi.
    Est. $662/mo

    Mercedes-Benz of Houston North

    4.6
    Check Availability
    Houston, TX (17 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $38,999

    $300
    22,077 mi.
    Est. $720/mo

    Group 1 Chevrolet Spring

    4.3
    Check Availability
    Houston, TX (17 mi)
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  • Black 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT HandlingBlack 2022 Lexus RX 350 F SPORT Handling

    $32,997

    $1K
    104,719 mi.
    Est. $609/mo

    BMW of West Houston

    4.8
    Check Availability
    Katy, TX (22 mi)
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  • Nightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 Base

    $43,995

    33,391 mi.
    Est. $812/mo

    Lexus of Southwest Houston

    4.8
    Check Availability
    Houston, TX (14 mi)
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  • Nightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 Base

    $39,991

    26,002 mi.
    Est. $738/mo

    ABZ Motors

    4.4
    Check Availability
    Houston, TX (13 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $41,516

    $979
    51,858 mi.
    Est. $766/mo

    Lexus of Southwest Houston

    4.8
    Check Availability
    Houston, TX (14 mi)
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  • Matador Red Mica 2022 Lexus RX 350 F SPORT Handling

    $49,600

    25,531 mi.
    Est. $915/mo

    Northside Lexus

    4.9
    Check Availability
    Spring, TX (23 mi)
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  • Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350Silver 2022 Lexus RX 350

    $39,998

    49,255 mi.
    Est. $738/mo

    CarMax Shreveport

    Check Availability
    $99 delivery to Houston, TX (11 mi)
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  • Brown 2022 Lexus RX 350Brown 2022 Lexus RX 350Brown 2022 Lexus RX 350Brown 2022 Lexus RX 350Brown 2022 Lexus RX 350Brown 2022 Lexus RX 350

    $43,998

    $3K
    25,186 mi.
    Est. $812/mo

    CarMax College Station

    4.6
    Check Availability
    Free delivery to Houston, TX (11 mi)
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  • Ultra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT Handling

    $41,813

    53,083 mi.
    Est. $772/mo

    Bryan College Station Toyota

    4.7
    Check Availability
    Bryan, TX (84 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $40,698

    50,550 mi.
    Est. $751/mo

    Lexus of Lakeway

    5.0
    Check Availability
    Lakeway, TX (160 mi)
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  • Ultra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT HandlingUltra White 2022 Lexus RX 350 F SPORT Handling

    $46,881

    31,674 mi.
    Est. $865/mo

    Shottenkirk Toyota San Antonio

    4.7
    Check Availability
    San Antonio, TX (187 mi)
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  • Nightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 Base

    $41,990

    $2K
    52,370 mi.
    Est. $775/mo

    Land Rover North Austin

    Check Availability
    Austin, TX (151 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $64,249 3 Good deals
2025 Lexus RX 350 $55,352 20 Good deals
2024 Lexus RX 350 $51,135 23 Good deals
2023 Lexus RX 350 $49,070 15 Good deals
2019 Lexus RX 350 $28,797 7 Good deals
2017 Lexus RX 350 $23,989 6 Good deals

About the 2022 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350
FAQs

How much does the 2022 Lexus RX 350 cost?

The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $41,010, with pricing starting at $26,995.

What is the MPG of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 compares to and/or competes against the following vehicles:


Is the 2022 Lexus RX 350 reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Is the 2022 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.

(13 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $49,400 Starting at $50,800
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling FWD RX 350 F SPORT Handling AWD
Inventory price
Starting at $51,800 Starting at $53,200
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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