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  • Gray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATIC

    $39,722

    $1.4K
    34,424 mi.
    Est. $748/mo

    Mossy GMC

    4.7
    New Orleans, LA (836 mi)
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  • Gray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATIC

    $39,722

    $1.4K
    34,424 mi.
    Est. $748/mo

    Mossy GMC

    4.7
    New Orleans, LA (836 mi)
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  • Hightech Silver 2021 Mercedes-Benz E-Class 4MATICHightech Silver 2021 Mercedes-Benz E-Class 4MATICHightech Silver 2021 Mercedes-Benz E-Class 4MATICHightech Silver 2021 Mercedes-Benz E-Class 4MATICHightech Silver 2021 Mercedes-Benz E-Class 4MATICHightech Silver 2021 Mercedes-Benz E-Class 4MATIC

    $36,120

    38,780 mi.
    Est. $680/mo

    Kendall Hyundai

    3.9
    Miami, FL (1,198 mi)
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  • Graphite 2021 Mercedes-Benz E-Class E 450 4MATICGraphite 2021 Mercedes-Benz E-Class E 450 4MATICGraphite 2021 Mercedes-Benz E-Class E 450 4MATICGraphite 2021 Mercedes-Benz E-Class E 450 4MATICGraphite 2021 Mercedes-Benz E-Class E 450 4MATICGraphite 2021 Mercedes-Benz E-Class E 450 4MATIC

    $42,988

    34,534 mi.
    Est. $810/mo

    Kia on Atlantic

    4.4
    Jacksonville, FL (869 mi)
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  • Black 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-Class

    $34,998

    48,508 mi.
    Est. $659/mo

    CarMax Louisville

    4.9
    Louisville, KY (276 mi)
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  • Black 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATIC

    $30,697

    78,490 mi.
    Est. $578/mo

    Route 17 Mitsubishi

    4.1
    Ramsey, NJ (701 mi)
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  • designo Diamond White Metallic 2021 Mercedes-Benz E-Class E 450 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 450 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 450 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 450 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 450 4MATICdesigno Diamond White Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC

    $39,980

    $2K
    13,254 mi.
    Est. $753/mo

    Global Belle Meade

    4.5
    Nashville, TN (402 mi)
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  • Black 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-ClassBlack 2021 Mercedes-Benz E-Class

    $47,998

    $2K
    28,195 mi.
    Est. $904/mo

    CarMax Tulsa

    4.6
    Tulsa, OK (600 mi)
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  • Patagonia Red Metallic 2021 Mercedes-Benz E-Class E 450 4MATICPatagonia Red Metallic 2021 Mercedes-Benz E-Class E 450 4MATICPatagonia Red Metallic 2021 Mercedes-Benz E-Class E 450 4MATICPatagonia Red Metallic 2021 Mercedes-Benz E-Class E 450 4MATICPatagonia Red Metallic 2021 Mercedes-Benz E-Class E 450 4MATICPatagonia Red Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC

    $39,010

    $400
    75,883 mi.
    Est. $735/mo

    Maserati of Naperville

    3.3
    Naperville, IL (30 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $33,685

    $500
    46,569 mi.
    Est. $635/mo

    DriveMax

    Manchester, CT (776 mi)
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  • White 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATIC

    $47,819

    27,422 mi.
    Est. $901/mo

    Hopper Motorplex

    Irving, TX (805 mi)
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  • Selenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Grey Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $39,900

    27,009 mi.
    Est. $752/mo

    Signature Pre-Owned

    Kearny, NJ (704 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $39,749

    31,336 mi.
    Est. $749/mo

    Auto Collection of Murfreesboro

    Murfreesboro, TN (423 mi)
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  • Gray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATIC

    $33,298

    60,393 mi.
    Est. $627/mo

    Mercedes-Benz of Billings

    Billings, MT (1,076 mi)
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  • White 2021 Mercedes-Benz E-Class E 450 4MATIC

    $42,698

    4,641 mi.
    Est. $804/mo

    Mercedes-Benz of Cherry Hill

    Cherry Hill, NJ (672 mi)
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  • Cavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATICCavansite Blue Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $36,766

    42,133 mi.
    Est. $693/mo

    Richardson Motors

    3.7
    Dubuque, IA (165 mi)
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  • Selenite Gray 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC

    $40,459

    36,090 mi.
    Est. $762/mo

    Mercedes-Benz of Milwaukee North

    4.8
    Glendale, WI (87 mi)
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  • Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGray 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $39,995

    67,123 mi.
    Est. $753/mo

    Texas Car Club

    4.5
    Houston, TX (947 mi)
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  • Polar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC

    $36,737

    $600
    82,083 mi.
    Est. $692/mo

    Mercedes-Benz of St. Paul

    4.5
    Maplewood, MN (348 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $40,790

    $1K
    43,417 mi.
    Est. $768/mo

    Mercedes-Benz of Annapolis

    4.9
    Annapolis, MD (620 mi)
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  • Gray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATIC

    $34,789

    $400
    61,745 mi.
    Est. $655/mo

    Sheehy Toyota of Laurel

    3.7
    Laurel, MD (599 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $21,781

    100,138 mi.
    Est. $410/mo

    Rt 603 Auto Mall

    4.6
    Irvington, NJ (701 mi)
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  • Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $41,155

    $1K
    49,525 mi.
    Est. $775/mo

    Jim Norton Toyota

    4.8
    Tulsa, OK (600 mi)
    Check Availability
  • Mojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMojave Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $38,898

    46,668 mi.
    Est. $733/mo

    Drive A Dream

    3.8
    Marietta, GA (572 mi)
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  • Graphite Grey Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $40,898

    55,566 mi.
    Est. $770/mo

    Riverside Ford - GA

    Macon, GA (661 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $26,215

    $1.7K
    76,994 mi.
    Est. $494/mo

    NJ Auto Xchange

    Atlantic Highlands, NJ (715 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2027 Mercedes-Benz E-Class E 450 4MATIC 6 Good deals
2026 Mercedes-Benz E-Class E 450 4MATIC 8 Good deals
2025 Mercedes-Benz E-Class E 450 4MATIC $63,313 15 Great deals
2024 Mercedes-Benz E-Class E 450 4MATIC $62,348 6 Great deals
2023 Mercedes-Benz E-Class E 450 4MATIC $45,436 64 Great deals
2022 Mercedes-Benz E-Class E 450 4MATIC $44,732 29 Great deals
2020 Mercedes-Benz E-Class E 450 4MATIC $33,934 17 Great deals
2019 Mercedes-Benz E-Class E 450 4MATIC $27,527 8 Great deals

About the 2021 Mercedes-Benz E-Class E 450 4MATIC

Basics

E 450 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
26
Transmission
9-Speed A/T
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2021 Mercedes-Benz E-Class E 450 4MATIC
FAQs

How much does the 2021 Mercedes-Benz E-Class E 450 4MATIC cost?

The 2021 Mercedes-Benz E-Class E 450 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class E 450 4MATIC is $37,784, with pricing starting at $21,781.

What is the MPG of the 2021 Mercedes-Benz E-Class E 450 4MATIC?

The 2021 Mercedes-Benz E-Class E 450 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 26 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz E-Class E 450 4MATIC?

The 2021 Mercedes-Benz E-Class E 450 4MATIC compares to and/or competes against the following vehicles:


Is the 2021 Mercedes-Benz E-Class E 450 4MATIC reliable?

The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.

Ratings (9 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Trims

E 450 (3 styles)

Style
E 450 4MATIC Sedan E 450 4MATIC Cabriolet E 450 4MATIC All-Terrain Wagon
Inventory price
Starting at $62,000 Starting at $74,450 Starting at $67,600
Combined MPG
26 25 24
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)

2021 Mercedes-Benz E-Class trims