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  • Polar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC

    $33,985

    37,271 mi.
    Est. $603/mo

    Porsche North Miami

    North Miami, FL (1,183 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $37,299

    45,854 mi.
    Est. $662/mo

    Dick Scott Motor Mall

    4.7
    Fowlerville, MI (190 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $41,894

    28,869 mi.
    Est. $744/mo

    Mercedes-Benz of Union

    4.7
    Union, NJ (697 mi)
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  • Gray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATIC

    $39,664

    86,880 mi.
    Est. $704/mo

    ALM Gwinnett

    4.4
    Duluth, GA (579 mi)
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  • GRAY 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGRAY 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGRAY 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGRAY 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGRAY 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGRAY 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $37,480

    71,767 mi.
    Est. $665/mo

    Discovery Auto Center, LLC

    4.2
    Tampa, FL (1,000 mi)
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  • Silver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-ClassSilver 2021 Mercedes-Benz E-Class

    $38,998

    35,968 mi.
    Est. $692/mo

    CarMax Salt Lake (South Jordan)

    4.4
    South Jordan, UT (1,261 mi)
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  • Selenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC

    $48,124

    24,309 mi.
    Est. $854/mo

    Genesis of Downers Grove

    4.3
    Downers Grove, IL (22 mi)
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  • Black 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATIC

    $39,698

    35,728 mi.
    Est. $705/mo

    Mercedes-Benz of Cherry Hill

    Cherry Hill, NJ (672 mi)
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  • Polar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC

    $39,220

    28,146 mi.
    Est. $696/mo

    Toyota of Midland

    4.5
    Midland, TX (1,051 mi)
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  • Polar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $47,396

    44,098 mi.
    Est. $842/mo

    Volkswagen of Rutland

    Rutland, VT (753 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $38,910

    37,759 mi.
    Est. $691/mo

    Mercedes-Benz Of Bend

    Bend, OR (1,698 mi)
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  • Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGray Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC

    $33,671

    $170
    38,742 mi.
    Est. $598/mo

    NowCar - Delivery from Miami, Fl for Orlando Fl

    Miami Lakes, FL (1,180 mi)
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  • Black 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATIC

    $33,867

    $1.7K
    61,280 mi.
    Est. $601/mo

    Mercedes-Benz of Indianapolis

    Indianapolis, IN (157 mi)
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  • White 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATICWhite 2021 Mercedes-Benz E-Class E 450 4MATIC

    $48,990

    28,388 mi.
    Est. $870/mo

    Grubbs Volvo Cars of Central Houston

    3.7
    Houston, TX (943 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $34,994

    $3.9K
    45,435 mi.
    Est. $621/mo

    Lexus of Fort Myers

    Fort Myers, FL (1,110 mi)
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  • Blue 2021 Mercedes-Benz E-Class 4MATICBlue 2021 Mercedes-Benz E-Class 4MATICBlue 2021 Mercedes-Benz E-Class 4MATICBlue 2021 Mercedes-Benz E-Class 4MATICBlue 2021 Mercedes-Benz E-Class 4MATICBlue 2021 Mercedes-Benz E-Class 4MATIC

    $30,874

    $1K
    75,084 mi.
    Est. $548/mo

    Hiley Automotive Group

    3.8
    Huntsville, AL (496 mi)
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  • Silver 2021 Mercedes-Benz E-Class E 450 4MATICSilver 2021 Mercedes-Benz E-Class E 450 4MATICSilver 2021 Mercedes-Benz E-Class E 450 4MATICSilver 2021 Mercedes-Benz E-Class E 450 4MATICSilver 2021 Mercedes-Benz E-Class E 450 4MATICSilver 2021 Mercedes-Benz E-Class E 450 4MATIC

    $40,179

    38,161 mi.
    Est. $713/mo

    Mercedes-Benz of North Haven

    4.2
    North Haven, CT (764 mi)
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  • Selenite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $35,981

    $500
    60,166 mi.
    Est. $639/mo

    Mercedes-Benz of West Chester (PA)

    4.5
    West Chester, PA (645 mi)
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  • Graphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC

    $32,388

    54,830 mi.
    Est. $575/mo

    Genesis of Monroeville

    4.3
    Monroeville, PA (424 mi)
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  • Graphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC

    $37,991

    $200
    85,321 mi.
    Est. $675/mo

    Mercedes-Benz of Beaumont

    4.5
    Beaumont, TX (894 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $43,064

    33,028 mi.
    Est. $765/mo

    Mercedes-Benz of Elmbrook

    4.9
    Waukesha, WI (85 mi)
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  • designo Selenite Grey Magno 2021 Mercedes-Benz E-Class 4MATICdesigno Selenite Grey Magno 2021 Mercedes-Benz E-Class 4MATICdesigno Selenite Grey Magno 2021 Mercedes-Benz E-Class 4MATICdesigno Selenite Grey Magno 2021 Mercedes-Benz E-Class 4MATICdesigno Selenite Grey Magno 2021 Mercedes-Benz E-Class 4MATICdesigno Selenite Grey Magno 2021 Mercedes-Benz E-Class 4MATIC

    $43,168

    $200
    15,588 mi.
    Est. $766/mo

    Mercedes-Benz of Orland Park

    4.5
    Orland Park, IL (22 mi)
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  • Obsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $42,700

    $1.1K
    62,691 mi.
    Est. $758/mo

    McCarthy Blue Springs Hyundai

    3.1
    Blue Springs, MO (402 mi)
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  • Blue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATICBlue 2021 Mercedes-Benz E-Class E 450 4MATIC

    $51,141

    43,279 mi.
    Est. $908/mo

    Rallye Motors

    4.8
    Roslyn, NY (729 mi)
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  • Red 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATIC

    $42,410

    75,680 mi.
    Est. $753/mo

    Maserati of Naperville

    3.5
    Naperville, IL (30 mi)
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  • Gray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATIC

    $43,431

    $430
    61,386 mi.
    Est. $771/mo

    Luxury Motor Cars

    1.5
    Hillside, NJ (701 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 450 4MATIC 3 Good deals
2025 Mercedes-Benz E-Class E 450 4MATIC $66,691 22 Good deals
2023 Mercedes-Benz E-Class E 450 4MATIC $47,678 35 Great deals
2022 Mercedes-Benz E-Class E 450 4MATIC $46,917 37 Great deals
2020 Mercedes-Benz E-Class E 450 4MATIC $34,973 10 Great deals
2019 Mercedes-Benz E-Class E 450 4MATIC $30,394 9 Great deals

About the 2021 Mercedes-Benz E-Class E 450 4MATIC

Basics

E 450 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
26
Transmission
9-Speed A/T
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2021 Mercedes-Benz E-Class E 450 4MATIC
FAQs

How much does the 2021 Mercedes-Benz E-Class E 450 4MATIC cost?

The 2021 Mercedes-Benz E-Class E 450 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class E 450 4MATIC is $41,097, with pricing starting at $29,495.

What is the MPG of the 2021 Mercedes-Benz E-Class E 450 4MATIC?

The 2021 Mercedes-Benz E-Class E 450 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 26 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz E-Class E 450 4MATIC?

The 2021 Mercedes-Benz E-Class E 450 4MATIC compares to and/or competes against the following vehicles:


Is the 2021 Mercedes-Benz E-Class E 450 4MATIC reliable?

The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.

Ratings (9 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Trims

E 450 (3 styles)

Style
E 450 4MATIC Sedan E 450 4MATIC Cabriolet E 450 4MATIC All-Terrain Wagon
Inventory price
Starting at $62,000 Starting at $74,450 Starting at $67,600
Combined MPG
26 25 24
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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Mercedes-Benz E-Class trims