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  • Red 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATICRed 2021 Mercedes-Benz E-Class E 450 4MATIC

    $44,098

    75,680 mi.
    Est. $829/mo

    Maserati of Naperville

    3.7
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    Naperville, IL (30 mi)

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  • Black 2021 Mercedes-Benz E-Class E 450 4MATIC

    $39,995

    $1K
    35,698 mi.
    Est. $752/mo

    Mercedes-Benz of Cherry Hill

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    Cherry Hill, NJ (672 mi)

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  • White 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATICWhite 2021 Mercedes-Benz E-Class 4MATIC

    $37,455

    $2.5K
    51,976 mi.
    Est. $704/mo

    Hanania Chrysler Dodge Jeep Ram

    4.6
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    St Augustine, FL (903 mi)
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  • Gray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATICGray 2021 Mercedes-Benz E-Class 4MATIC

    $44,988

    23,706 mi.
    Est. $846/mo

    Auto Web Expo

    4.6
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    Plano, TX (796 mi)
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  • Black 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATIC

    $43,991

    12,816 mi.
    Est. $827/mo

    Metro Ford

    4.9
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    Miami, FL (1,186 mi)
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  • Obsidian Black Metallic 2021 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2021 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2021 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2021 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2021 Mercedes-Benz E-Class 4MATICObsidian Black Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $48,788

    27,041 mi.
    Est. $917/mo

    iCars Chicago

    4.9
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    Skokie, IL (13 mi)
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  • Graphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $40,990

    $781
    72,767 mi.
    Est. $770/mo

    Discovery Auto Center, LLC

    4.2
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    Tampa, FL (1,000 mi)
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  • Gray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATIC

    $38,991

    84,520 mi.
    Est. $733/mo

    Mercedes-Benz of Beaumont

    4.5
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    Beaumont, TX (894 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $28,995

    75,261 mi.
    Est. $545/mo

    Mountain Motors, Inc

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    Santa Clarita, CA (1,746 mi)
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  • Black 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATICBlack 2021 Mercedes-Benz E-Class E 450 4MATIC

    $36,688

    61,280 mi.
    Est. $690/mo

    Mercedes-Benz of Indianapolis

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    Indianapolis, IN (157 mi)
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  • Polar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATICPolar White 2021 Mercedes-Benz E-Class E 450 4MATIC

    $37,595

    37,173 mi.
    Est. $707/mo

    Porsche North Miami

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    North Miami, FL (1,183 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $39,994

    $1K
    45,435 mi.
    Est. $752/mo

    Lexus of Fort Myers

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    Fort Myers, FL (1,110 mi)
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  • Black 2021 Mercedes-Benz E-Class E 450 4MATIC SedanBlack 2021 Mercedes-Benz E-Class E 450 4MATIC SedanBlack 2021 Mercedes-Benz E-Class E 450 4MATIC SedanBlack 2021 Mercedes-Benz E-Class E 450 4MATIC SedanBlack 2021 Mercedes-Benz E-Class E 450 4MATIC SedanBlack 2021 Mercedes-Benz E-Class E 450 4MATIC Sedan

    $36,495

    39,755 mi.
    Est. $686/mo

    Foley Motorsports

    5.0
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    Shrewsbury, MA (818 mi)
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  • Gray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATICGray 2021 Mercedes-Benz E-Class E 450 4MATIC

    $38,420

    $500
    86,880 mi.
    Est. $722/mo

    ALM Gwinnett

    4.5
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    Duluth, GA (579 mi)
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  • Gray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-ClassGray 2021 Mercedes-Benz E-Class

    $52,998

    31,606 mi.
    Est. $996/mo

    CarMax Texas Stadium (Irving)

    4.2
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    Irving, TX (805 mi)
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  • Black 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATICBlack 2021 Mercedes-Benz E-Class 4MATIC

    $42,995

    33,028 mi.
    Est. $808/mo

    Mercedes-Benz of Elmbrook

    4.9
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    Waukesha, WI (85 mi)
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  • Graphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATICGraphite Gray 2021 Mercedes-Benz E-Class E 450 4MATIC

    $33,588

    54,830 mi.
    Est. $631/mo

    Genesis of Monroeville

    4.3
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    Monroeville, PA (424 mi)
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  • Cirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATICCirrus Silver Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $50,495

    $2K
    18,124 mi.
    Est. $949/mo

    Mercedes-Benz of White Plains

    4.8
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    White Plains, NY (720 mi)
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  • Graphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $54,998

    38,884 mi.
    Est. $1,034/mo

    Mercedes-Benz of Edison

    5.0
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    Edison, NJ (696 mi)
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  • Polar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATICPolar White 2021 Mercedes-Benz E-Class 4MATIC

    $55,985

    14,502 mi.
    Est. $1,052/mo

    Mercedes-Benz of Morristown

    4.9
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    Morristown, NJ (687 mi)
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  • Graphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATICGraphite Grey Metallic 2021 Mercedes-Benz E-Class 4MATIC

    $35,085

    51,630 mi.
    Est. $659/mo

    Porsche Bellevue

    4.8
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    Bellevue, WA (1,726 mi)
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  • Cirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainCirrus Silver Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $37,693

    78,482 mi.
    Est. $709/mo

    Noblesville Imports

    4.8
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    Noblesville, IN (157 mi)
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  • Selenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATICSelenite Gray Metallic 2021 Mercedes-Benz E-Class E 450 4MATIC

    $47,992

    24,309 mi.
    Est. $902/mo

    Genesis of Downers Grove

    4.6
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    Downers Grove, IL (22 mi)
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  • BLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBLACK 2021 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $41,500

    $500
    58,785 mi.
    Est. $780/mo

    Jacobs Mitsubishi

    4.0
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    New Port Richey, FL (981 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class E 450 4MATIC 2 Good deals
2025 Mercedes-Benz E-Class E 450 4MATIC $64,894 11 Great deals
2024 Mercedes-Benz E-Class E 450 4MATIC $64,294 6 Great deals
2023 Mercedes-Benz E-Class E 450 4MATIC $48,515 53 Great deals
2022 Mercedes-Benz E-Class E 450 4MATIC $46,009 35 Great deals
2020 Mercedes-Benz E-Class E 450 4MATIC $33,253 9 Great deals
2019 Mercedes-Benz E-Class E 450 4MATIC $30,171 23 Great deals

About the 2021 Mercedes-Benz E-Class E 450 4MATIC

Basics

E 450 4MATIC shown.

Seating
5
Door count
4
Drivetrain
All Wheel Drive
Combined MPG
26
Transmission
9-Speed A/T
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2021 Mercedes-Benz E-Class E 450 4MATIC
FAQs

How much does the 2021 Mercedes-Benz E-Class E 450 4MATIC cost?

The 2021 Mercedes-Benz E-Class E 450 4MATIC price depends on several factors, including optional features, mileage, vehicle history and location. The nationwide average price for a 2021 E-Class E 450 4MATIC is $41,803, with pricing starting at $27,295.

What is the MPG of the 2021 Mercedes-Benz E-Class E 450 4MATIC?

The 2021 Mercedes-Benz E-Class E 450 4MATIC offers up to 23 MPG in city driving and 30 MPG on the highway for a combined rating of 26 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle options, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Mercedes-Benz E-Class E 450 4MATIC?

The 2021 Mercedes-Benz E-Class E 450 4MATIC compares to and/or competes against the following vehicles:


Is the 2021 Mercedes-Benz E-Class E 450 4MATIC reliable?

The 2021 Mercedes-Benz E-Class has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 E-Class owners.

Ratings (9 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.4
Performance
4.3
Value
4.0
Exterior
4.4
Reliability
3.9
Trims

E 450 (3 styles)

Style
E 450 4MATIC Sedan E 450 4MATIC Cabriolet E 450 4MATIC All-Terrain Wagon
Inventory price
Starting at $62,000 Starting at $74,450 Starting at $67,600
Combined MPG
26 25 24
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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Mercedes-Benz E-Class trims