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  • Atomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 BaseAtomic Silver 2021 Lexus RX 350 Base

    $31,689

    97,240 mi.
    Est. $561/mo

    Lexus of Birmingham

    4.9
    Check Availability
    Irondale, AL (9 mi)
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  • Caviar 2021 Lexus RX 350 Base

    $31,998

    92,432 mi.
    Est. $567/mo

    Tameron Honda

    4.1
    Check Availability
    Birmingham, AL (9 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 Base

    $35,976

    61,662 mi.
    Est. $637/mo

    Tameron Honda

    4.1
    Check Availability
    Birmingham, AL (9 mi)
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  • $38,937

    55,465 mi.
    Est. $690/mo

    Hendrick Subaru

    5.0
    Check Availability
    Hoover, AL (11 mi)
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  • Caviar 2021 Lexus RX 350 F SPORT Appearance

    $29,855

    104,348 mi.
    Est. $529/mo

    Exclusive Auto Wholesale

    4.8
    Check Availability
    Pelham, AL (15 mi)
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  • Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350

    $34,998

    72,632 mi.
    Est. $620/mo

    CarMax Dothan

    Check Availability
    $149 delivery to Hoover, AL (12 mi)
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  • Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350

    $47,998

    6,510 mi.
    Est. $850/mo

    CarMax Norcross

    3.9
    Check Availability
    Free delivery to Hoover, AL (12 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $38,389

    55,239 mi.
    Est. $680/mo

    Mercedes-Benz of Columbus

    4.8
    Check Availability
    Columbus, GA (127 mi)
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  • Celestial GF 2021 Lexus RX 350 F SPORT AppearanceCelestial GF 2021 Lexus RX 350 F SPORT AppearanceCelestial GF 2021 Lexus RX 350 F SPORT AppearanceCelestial GF 2021 Lexus RX 350 F SPORT AppearanceCelestial GF 2021 Lexus RX 350 F SPORT AppearanceCelestial GF 2021 Lexus RX 350 F SPORT Appearance

    $35,445

    $1.3K
    94,403 mi.
    Est. $628/mo

    Capital Toyota

    4.8
    Check Availability
    Chattanooga, TN (139 mi)
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  • Black 2021 Lexus RX 350 F-SPORT HandlingBlack 2021 Lexus RX 350 F-SPORT HandlingBlack 2021 Lexus RX 350 F-SPORT HandlingBlack 2021 Lexus RX 350 F-SPORT HandlingBlack 2021 Lexus RX 350 F-SPORT HandlingBlack 2021 Lexus RX 350 F-SPORT Handling

    $40,998

    51,867 mi.
    Est. $726/mo

    CarMax Town Center

    4.2
    Check Availability
    Kennesaw, GA (133 mi)
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  • Caviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 Base

    $33,260

    $336
    61,091 mi.
    Est. $589/mo

    Gravity Motor Cars

    Check Availability
    Marietta, GA (135 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $29,990

    $2.4K
    91,590 mi.
    Est. $531/mo

    Butler Lexus of South Atlanta

    4.7
    Check Availability
    Union City, GA (132 mi)
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  • Beige Metallic 2021 Lexus RX 350 350Beige Metallic 2021 Lexus RX 350 350Beige Metallic 2021 Lexus RX 350 350Beige Metallic 2021 Lexus RX 350 350Beige Metallic 2021 Lexus RX 350 350Beige Metallic 2021 Lexus RX 350 350

    $31,600

    $1.1K
    78,268 mi.
    Est. $560/mo

    Lithia Springs Ford

    4.8
    Check Availability
    Lithia Springs, GA (128 mi)
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  • Silver 2021 Lexus RX 350 BaseSilver 2021 Lexus RX 350 BaseSilver 2021 Lexus RX 350 BaseSilver 2021 Lexus RX 350 BaseSilver 2021 Lexus RX 350 BaseSilver 2021 Lexus RX 350 Base

    $35,000

    43,408 mi.
    Est. $620/mo

    1st Choice Autos

    3.4
    Check Availability
    Smyrna, GA (133 mi)
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  • $43,772

    41,578 mi.
    Est. $775/mo

    Gravity Motor Cars

    Check Availability
    Marietta, GA (135 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $62,697
2025 Lexus RX 350 $54,902 7 Good deals
2024 Lexus RX 350 $52,365 9 Good deals
2023 Lexus RX 350 $48,709 5 Great deals

About the 2021 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Lexus RX 350
FAQs

How much does the 2021 Lexus RX 350 cost?

The 2021 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 RX 350 is $37,065, with pricing starting at $26,525.

What is the MPG of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 compares to and/or competes against the following vehicles:


  • Toyota Highlander
  • Lexus RX 350h
  • Lexus RX 350L
  • Genesis GV70
  • Acura RDX
  • Acura MDX

Is the 2021 Lexus RX 350 reliable?

The 2021 Lexus RX 350 has an average reliability rating of 4.8 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 RX 350 owners.

Is the 2021 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2021 Lexus RX 350.

(63 reviews)
Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Ratings (63 reviews)

88% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Trims

RX 350 (2 styles)

Style
RX 350 AWD RX 350 FWD
Inventory price
Starting at $46,620 Starting at $45,220
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $48,700 Starting at $50,100
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling AWD RX 350 F SPORT Handling FWD
Inventory price
Starting at $52,500 Starting at $51,100
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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