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  • Ultra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT HandlingUltra White 2021 Lexus RX 350 F SPORT Handling

    $39,995

    $1K
    57,838 mi.
    Est. $683/mo

    Koons of Falls Church Ford

    3.8
    Check Availability
    Falls Church, VA (22 mi)

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  • Nebula Gray Pearl 2021 Lexus RX 350 F SPORT PerformanceNebula Gray Pearl 2021 Lexus RX 350 F SPORT PerformanceNebula Gray Pearl 2021 Lexus RX 350 F SPORT PerformanceNebula Gray Pearl 2021 Lexus RX 350 F SPORT PerformanceNebula Gray Pearl 2021 Lexus RX 350 F SPORT PerformanceNebula Gray Pearl 2021 Lexus RX 350 F SPORT Performance

    $37,995

    44,847 mi.
    Est. $649/mo

    CarVault of Chantilly

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    Chantilly, VA (7 mi)
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  • Atomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 PremiumAtomic Silver 2021 Lexus RX 350 Premium

    $45,539

    $800
    41,666 mi.
    Est. $777/mo

    Pohanka Lexus

    3.8
    Check Availability
    Chantilly, VA (9 mi)
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  • Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350Black 2021 Lexus RX 350

    $39,998

    26,191 mi.
    Est. $683/mo

    CarMax Potomac Mills

    4.3
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    Woodbridge, VA (28 mi)
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  • Nightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 BaseNightfall Mica 2021 Lexus RX 350 Base

    $38,092

    38,103 mi.
    Est. $650/mo

    Safford Mazda Sterling

    4.5
    Check Availability
    Sterling, VA (5 mi)
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  • Caviar 2021 Lexus RX 350 F SPORT AppearanceCaviar 2021 Lexus RX 350 F SPORT AppearanceCaviar 2021 Lexus RX 350 F SPORT AppearanceCaviar 2021 Lexus RX 350 F SPORT AppearanceCaviar 2021 Lexus RX 350 F SPORT AppearanceCaviar 2021 Lexus RX 350 F SPORT Appearance

    $37,489

    $400
    82,811 mi.
    Est. $640/mo

    Pohanka Lexus

    3.8
    Check Availability
    Chantilly, VA (9 mi)
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  • Obsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 BaseObsidian 2021 Lexus RX 350 Base

    $36,582

    $1.3K
    68,049 mi.
    Est. $625/mo

    Honda of Chantilly

    4.0
    Check Availability
    Chantilly, VA (8 mi)
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  • Matador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 Base

    $45,689

    $3.2K
    46,141 mi.
    Est. $780/mo

    Pohanka Lexus

    3.8
    Check Availability
    Chantilly, VA (9 mi)
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  • Mica 2021 Lexus RX 350 Base

    $43,049

    24,941 mi.
    Est. $735/mo

    Easterns Automotive Group of Sterling

    4.8
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    Sterling, VA (4 mi)
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  • Caviar 2021 Lexus RX 350 Base

    $45,889

    43,886 mi.
    Est. $783/mo

    Pohanka Lexus

    3.8
    Check Availability
    Chantilly, VA (9 mi)
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  • Caviar 2021 Lexus RX 350 LuxuryCaviar 2021 Lexus RX 350 LuxuryCaviar 2021 Lexus RX 350 LuxuryCaviar 2021 Lexus RX 350 LuxuryCaviar 2021 Lexus RX 350 LuxuryCaviar 2021 Lexus RX 350 Luxury

    $32,995

    80,593 mi.
    Est. $563/mo

    Sound Auto Wholesalers

    4.2
    Check Availability
    $878 delivery from Branford, CT (293 mi)
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  • Eminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 BaseEminent White Pearl 2021 Lexus RX 350 Base

    $33,676

    77,681 mi.
    Est. $575/mo

    Bob Johnson Used

    4.0
    Check Availability
    $425 delivery from Rochester, NY (284 mi)
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  • Matador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 BaseMatador Red Mica 2021 Lexus RX 350 Base

    $40,790

    $1.1K
    46,311 mi.
    Est. $696/mo

    DARCARS Lexus Of Silver Spring

    4.7
    Check Availability
    Silver Spring, MD (31 mi)
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  • Caviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 BaseCaviar 2021 Lexus RX 350 Base

    $35,699

    $300
    66,570 mi.
    Est. $609/mo

    DARCARS Toyota Silver Spring

    2.8
    Check Availability
    Silver Spring, MD (31 mi)
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  • $39,300

    29,935 mi.
    Est. $671/mo

    Apple Ford Lincoln

    3.9
    Check Availability
    Columbia, MD (41 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $64,762 1 Good deal
2024 Lexus RX 350 $51,291 16 Good deals
2023 Lexus RX 350 $50,015 24 Good deals
2022 Lexus RX 350 $41,615 10 Good deals

About the 2021 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Lexus RX 350
FAQs

How much does the 2021 Lexus RX 350 cost?

The 2021 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 RX 350 is $37,161, with pricing starting at $20,744.

What is the MPG of the 2021 Lexus RX 350?

The 2021 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2021 Lexus RX 350 reliable?

The 2021 Lexus RX 350 has an average reliability rating of 4.8 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 RX 350 owners.

Is the 2021 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2021 Lexus RX 350.

(63 reviews)
Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Ratings (63 reviews)

88% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.7
Interior
4.7
Performance
4.7
Value
4.6
Exterior
4.6
Reliability
4.8
Trims

RX 350 (2 styles)

Style
RX 350 AWD RX 350 FWD
Inventory price
Starting at $46,620 Starting at $45,220
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $48,700 Starting at $50,100
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling AWD RX 350 F SPORT Handling FWD
Inventory price
Starting at $52,500 Starting at $51,100
Combined MPG
22 23
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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