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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $43,113

    33,619 mi.
    Est. $788/mo

    Westside Lexus

    4.8
    Houston, TX (23 mi)
    Check Availability

  • Black 2022 Lexus RX 350 BaseBlack 2022 Lexus RX 350 BaseBlack 2022 Lexus RX 350 BaseBlack 2022 Lexus RX 350 BaseBlack 2022 Lexus RX 350 BaseBlack 2022 Lexus RX 350 Base

    $31,064

    $2.5K
    83,000 mi.
    Est. $568/mo

    Classic Buick GMC

    4.7
    Houston, TX (26 mi)
    Check Availability
  • Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350

    $37,998

    50,656 mi.
    Est. $695/mo

    CarMax Cy-Fair

    4.5
    Houston, TX (18 mi)
    Check Availability
  • Caviar 2022 Lexus RX 350 PremiumCaviar 2022 Lexus RX 350 PremiumCaviar 2022 Lexus RX 350 PremiumCaviar 2022 Lexus RX 350 PremiumCaviar 2022 Lexus RX 350 PremiumCaviar 2022 Lexus RX 350 Premium

    $36,113

    73,033 mi.
    Est. $660/mo

    Westside Lexus

    4.8
    Houston, TX (23 mi)
    Check Availability
  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $35,420

    $600
    55,771 mi.
    Est. $648/mo

    Mossy Nissan

    4.8
    Houston, TX (24 mi)
    Check Availability
  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $36,900

    $1.3K
    68,626 mi.
    Est. $675/mo

    Northside Lexus

    4.9
    Spring, TX (5 mi)
    Check Availability
  • Ultra White 2022 Lexus RX 350 F SPORT AppearanceUltra White 2022 Lexus RX 350 F SPORT AppearanceUltra White 2022 Lexus RX 350 F SPORT AppearanceUltra White 2022 Lexus RX 350 F SPORT AppearanceUltra White 2022 Lexus RX 350 F SPORT AppearanceUltra White 2022 Lexus RX 350 F SPORT Appearance

    $34,222

    $1K
    45,675 mi.
    Est. $626/mo

    HGreg.com Houston

    3.6
    Houston, TX (25 mi)
    Check Availability
  • Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350

    $39,998

    46,862 mi.
    Est. $731/mo

    CarMax North Houston

    4.6
    Houston, TX (5 mi)
    Check Availability
  • Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350

    $42,998

    39,494 mi.
    Est. $786/mo

    CarMax North Houston

    4.6
    Houston, TX (5 mi)
    Check Availability
  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $37,720

    $500
    60,827 mi.
    Est. $690/mo

    Lexus of Southwest Houston

    4.8
    Houston, TX (29 mi)
    Check Availability
  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $43,113

    33,619 mi.
    Est. $788/mo

    Westside Lexus

    4.8
    Houston, TX (23 mi)
    Check Availability
  • Atomic Silver 2022 Lexus RX 350 Base

    $38,965

    66,232 mi.
    Est. $712/mo

    Northside Lexus

    4.9
    Spring, TX (5 mi)
    Check Availability
  • Tan 2022 Lexus RX 350Tan 2022 Lexus RX 350Tan 2022 Lexus RX 350Tan 2022 Lexus RX 350Tan 2022 Lexus RX 350Tan 2022 Lexus RX 350

    $39,998

    50,520 mi.
    Est. $731/mo

    CarMax Kenner

    4.5
    $299 delivery to Houston, TX (5 mi)
    Check Availability
  • Black 2022 Lexus RX 350 F-SPORT HandlingBlack 2022 Lexus RX 350 F-SPORT HandlingBlack 2022 Lexus RX 350 F-SPORT HandlingBlack 2022 Lexus RX 350 F-SPORT HandlingBlack 2022 Lexus RX 350 F-SPORT HandlingBlack 2022 Lexus RX 350 F-SPORT Handling

    $44,998

    41,354 mi.
    Est. $823/mo

    CarMax Tulsa

    4.6
    $199 delivery to Houston, TX (5 mi)
    Check Availability
  • Gray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 BaseGray Pearl 2022 Lexus RX 350 Base

    $40,054

    53,882 mi.
    Est. $732/mo

    Big Star Chrysler Jeep Dodge Ram Fiat Clear Lake

    4.0
    Webster, TX (36 mi)
    Check Availability
  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $37,222

    63,321 mi.
    Est. $681/mo

    Group 1 Buick GMC South

    4.6
    Houston, TX (33 mi)
    Check Availability
  • Nightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 BaseNightfall Mica 2022 Lexus RX 350 Base

    $31,820

    $1.4K
    89,085 mi.
    Est. $582/mo

    Lexus Clear Lake

    4.8
    Friendswood, TX (38 mi)
    Check Availability

Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $62,027 5 Great deals
2025 Lexus RX 350 $52,275 6 Great deals
2024 Lexus RX 350 $48,186 12 Great deals
2023 Lexus RX 350 $44,477 19 Good deals
2017 Lexus RX 350 $25,556 10 Good deals

About the 2022 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350
FAQs

How much does the 2022 Lexus RX 350 cost?

The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $38,208, with pricing starting at $25,120.

What is the MPG of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 compares to and/or competes against the following vehicles:


Is the 2022 Lexus RX 350 reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Is the 2022 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.

(13 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $49,400 Starting at $50,800
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling FWD RX 350 F SPORT Handling AWD
Inventory price
Starting at $51,800 Starting at $53,200
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

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