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  • Black 2022 Mercedes-Benz S-Class S 580

    $69,413

    48,448 mi.
    Est. $1,308/mo

    Gravity Autos Jacksonville

    4.1
    Jacksonville, FL (868 mi)
    Check Availability

  • Black 2022 Mercedes-Benz S-Class S 580

    $69,413

    48,448 mi.
    Est. $1,308/mo

    Gravity Autos Jacksonville

    4.1
    Jacksonville, FL (868 mi)
    Check Availability

  • Nautical Blue Metallic 2022 Mercedes-Benz S-Class S 580Nautical Blue Metallic 2022 Mercedes-Benz S-Class S 580Nautical Blue Metallic 2022 Mercedes-Benz S-Class S 580Nautical Blue Metallic 2022 Mercedes-Benz S-Class S 580Nautical Blue Metallic 2022 Mercedes-Benz S-Class S 580Nautical Blue Metallic 2022 Mercedes-Benz S-Class S 580

    $71,917

    $2.7K
    11,836 mi.
    Est. $1,355/mo

    Loveland Ford Lincoln

    4.4
    Loveland, CO (909 mi)
    Check Availability
  • MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580

    $63,280

    $3K
    17,730 mi.
    Est. $1,192/mo

    Motor City Mini

    Southfield, MI (227 mi)
    Check Availability
  • Gray 2022 Mercedes-Benz S-Class S 580Gray 2022 Mercedes-Benz S-Class S 580Gray 2022 Mercedes-Benz S-Class S 580Gray 2022 Mercedes-Benz S-Class S 580Gray 2022 Mercedes-Benz S-Class S 580Gray 2022 Mercedes-Benz S-Class S 580

    $55,700

    $700
    46,209 mi.
    Est. $1,049/mo

    Autobahn USA Dedham

    4.4
    Dedham, MA (844 mi)
    Check Availability
  • Hightech Silver 2022 Mercedes-Benz S-ClassHightech Silver 2022 Mercedes-Benz S-ClassHightech Silver 2022 Mercedes-Benz S-Class

    $65,995

    $2K
    45,244 mi.
    Est. $1,243/mo

    New Country Motor Cars

    3.7
    Hartford, CT (770 mi)
  • Black 2022 Mercedes-Benz S-Class S 580 4MATICBlack 2022 Mercedes-Benz S-Class S 580 4MATICBlack 2022 Mercedes-Benz S-Class S 580 4MATICBlack 2022 Mercedes-Benz S-Class S 580 4MATICBlack 2022 Mercedes-Benz S-Class S 580 4MATICBlack 2022 Mercedes-Benz S-Class S 580 4MATIC

    $71,999

    10,795 mi.
    Est. $1,356/mo

    Private seller: David

    Millburn, NJ (695 mi)
    Contact Seller
  • White 2022 Mercedes-Benz S-Class S 580 4MATICWhite 2022 Mercedes-Benz S-Class S 580 4MATICWhite 2022 Mercedes-Benz S-Class S 580 4MATICWhite 2022 Mercedes-Benz S-Class S 580 4MATICWhite 2022 Mercedes-Benz S-Class S 580 4MATICWhite 2022 Mercedes-Benz S-Class S 580 4MATIC

    $78,000

    20,500 mi.
    Est. $1,469/mo

    Private seller: Vlad

    Miami, FL (1,192 mi)
    Contact Seller
  • MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580

    $74,980

    5,298 mi.
    Est. $1,413/mo

    Ultimo Motors North Shore

    3.2
    Northbrook, IL (19 mi)
    Check Availability
  • Selenite Gray Metallic 2022 Mercedes-Benz S-Class S 580Selenite Gray Metallic 2022 Mercedes-Benz S-Class S 580Selenite Gray Metallic 2022 Mercedes-Benz S-Class S 580Selenite Gray Metallic 2022 Mercedes-Benz S-Class S 580Selenite Gray Metallic 2022 Mercedes-Benz S-Class S 580Selenite Gray Metallic 2022 Mercedes-Benz S-Class S 580

    $72,890

    $2K
    29,768 mi.
    Est. $1,373/mo

    Mercedes-Benz Of Bloomfield Hills

    3.4
    Bloomfield Hills, MI (231 mi)
    Check Availability
  • Black 2022 Mercedes-Benz S-ClassBlack 2022 Mercedes-Benz S-ClassBlack 2022 Mercedes-Benz S-Class

    $57,497

    $3K
    59,705 mi.
    Est. $1,083/mo

    Flagship Motorcars of Lynnfield

    4.9
    Lynnfield, MA (852 mi)
  • Nautical Blue 2022 Mercedes-Benz S-ClassNautical Blue 2022 Mercedes-Benz S-ClassNautical Blue 2022 Mercedes-Benz S-Class

    $56,081

    43,973 mi.
    Est. $1,057/mo

    Mercedes-Benz of Los Angeles

    4.6
    Los Angeles, CA (1,744 mi)
  • Black 2022 Mercedes-Benz S-Class S 580 4MATICBlack 2022 Mercedes-Benz S-Class S 580 4MATICBlack 2022 Mercedes-Benz S-Class S 580 4MATIC

    $56,427

    $441
    70,439 mi.
    Est. $1,063/mo

    Park Place Motorcars Dallas

    4.5
    Dallas, TX (803 mi)
  • Graphite Grey Metallic 2022 Mercedes-Benz S-ClassGraphite Grey Metallic 2022 Mercedes-Benz S-ClassGraphite Grey Metallic 2022 Mercedes-Benz S-Class

    $68,639

    $1K
    41,995 mi.
    Est. $1,293/mo

    Mercedes-Benz Of Athens

    4.8
    Watkinsville, GA (596 mi)
  • MANUFAKTUR Diamond White 2022 Mercedes-Benz S-ClassMANUFAKTUR Diamond White 2022 Mercedes-Benz S-ClassMANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class

    $68,349

    27,026 mi.
    Est. $1,288/mo

    Park Place Motorcars Fort Worth

    4.8
    Fort Worth, TX (833 mi)
  • MANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz S-Class S 580 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz S-Class S 580 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz S-Class S 580 4MATIC

    $71,888

    $111
    12,904 mi.
    Est. $1,354/mo

    Mercedes-Benz of Honolulu

    Honolulu, HI (4,249 mi)
  • Obsidian Black Metallic 2022 Mercedes-Benz S-Class S 580 4MATICObsidian Black Metallic 2022 Mercedes-Benz S-Class S 580 4MATICObsidian Black Metallic 2022 Mercedes-Benz S-Class S 580 4MATIC

    $73,432

    $210
    19,708 mi.
    Est. $1,383/mo

    Mercedes-Benz of Smithtown

    4.9
    St. James, NY (754 mi)
  • Graphite Grey Metallic 2022 Mercedes-Benz S-Class S 580 4MATICGraphite Grey Metallic 2022 Mercedes-Benz S-Class S 580 4MATICGraphite Grey Metallic 2022 Mercedes-Benz S-Class S 580 4MATIC

    $73,495

    19,185 mi.
    Est. $1,385/mo

    Mercedes-Benz of College Station

    College Station, TX (916 mi)
  • Diamond White 2022 Mercedes-Benz S-ClassDiamond White 2022 Mercedes-Benz S-ClassDiamond White 2022 Mercedes-Benz S-Class

    $58,467

    58,116 mi.
    Est. $1,101/mo

    Mercedes-Benz of Oakland

    Oakland, CA (1,846 mi)
  • Diamond White 2022 Mercedes-Benz S-Class S 580 4MATICDiamond White 2022 Mercedes-Benz S-Class S 580 4MATICDiamond White 2022 Mercedes-Benz S-Class S 580 4MATIC

    $67,999

    32,638 mi.
    Est. $1,281/mo

    Mercedes-Benz Of Southampton

    Southampton, NY (791 mi)
  • Selenite Grey Metallic 2022 Mercedes-Benz S-Class S 580 4MATICSelenite Grey Metallic 2022 Mercedes-Benz S-Class S 580 4MATICSelenite Grey Metallic 2022 Mercedes-Benz S-Class S 580 4MATIC

    $74,827

    14,177 mi.
    Est. $1,410/mo

    Mercedes-Benz of Smithtown

    4.9
    St. James, NY (754 mi)
  • Silver 2022 Mercedes-Benz S-ClassSilver 2022 Mercedes-Benz S-ClassSilver 2022 Mercedes-Benz S-Class

    $59,995

    23,024 mi.
    Est. $1,130/mo

    Mercedes-Benz of Caldwell

    West Caldwell, NJ (694 mi)
  • Hightech Silver 2022 Mercedes-Benz S-Class S 580 4MATICHightech Silver 2022 Mercedes-Benz S-Class S 580 4MATICHightech Silver 2022 Mercedes-Benz S-Class S 580 4MATIC

    $70,862

    22,338 mi.
    Est. $1,335/mo

    Mercedes-Benz of Wappingers Falls

    Wappingers Falls, NY (708 mi)
  • MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 580

    $60,625

    28,201 mi.
    Est. $1,142/mo

    Texas Autos Direct

    3.9
    Mesquite, TX (798 mi)
    Check Availability
  • Blue 2022 Mercedes-Benz S-Class S 580 4MATICBlue 2022 Mercedes-Benz S-Class S 580 4MATICBlue 2022 Mercedes-Benz S-Class S 580 4MATICBlue 2022 Mercedes-Benz S-Class S 580 4MATICBlue 2022 Mercedes-Benz S-Class S 580 4MATICBlue 2022 Mercedes-Benz S-Class S 580 4MATIC

    $62,000

    33,777 mi.
    Est. $1,168/mo

    Private seller: Phoebe

    Chino Hills, CA (1,719 mi)
    Contact Seller
  • MANUFAKTUR Diamond White 2022 Mercedes-Benz S-Class S 500 4MATIC

    $55,000

    $2K
    46,031 mi.
    Est. $1,036/mo

    Open Road of Bridgewater / smart center of Bridgewater

    4.1
    Bridgewater, NJ (684 mi)

About the 2022 Mercedes-Benz S-Class

Basics

S 500 4MATIC shown (base trim).

Seating
5
Door count
4
Drivetrain
All-wheel Drive
Combined MPG
24
Transmission
9-Speed A/T
Engine
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
Side view of the 2022 Mercedes-Benz S-Class
FAQs

What is the MPG of the 2022 Mercedes-Benz S-Class?

The 2022 Mercedes-Benz S-Class offers up to 21 MPG in city driving and 30 MPG on the highway for a combined rating of 24 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2022 Mercedes-Benz S-Class reliable?

The 2022 Mercedes-Benz S-Class has an average reliability rating of 3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 S-Class owners.

Is the 2022 Mercedes-Benz S-Class a good sedan?

Below are the Cars.com consumer ratings for the 2022 Mercedes-Benz S-Class.

(4 reviews)
Rating breakdown (out of 5):
Comfort
5.0
Interior
4.0
Performance
4.5
Value
3.5
Exterior
4.2
Reliability
3.0
Ratings (4 reviews)

50% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
5.0
Interior
4.0
Performance
4.5
Value
3.5
Exterior
4.2
Reliability
3.0
Trims

S 500 (1 style)

Style
S 500 4MATIC Sedan
Inventory price
Starting at $111,100
Combined MPG
24
Engine
429.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)

S 580 (1 style)

Style
S 580 4MATIC Sedan
Inventory price
Starting at $117,700
Combined MPG
19
Engine
496.0-hp, 4.0-liter, 8 Cylinder Engine (Gasoline/Mild Electric Hybrid)