Skip to main content
Best match Lowest price Highest price Lowest mileage Highest mileage Nearest location Best deal Newest year Oldest year Newest listed Oldest listed
Skip to Filters
  • Caviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 BaseCaviar 2021 Lexus IS 350 Base

    $42,725

    $3.4K
    39,019 mi.
    Est. $789/mo

    Sewell Lexus of Dallas

    3.3
    Check Availability
    Dallas, TX (5 mi)
    Quick view
  • Silver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 BaseSilver 2021 Lexus IS 350 Base

    $34,488

    $1.1K
    78,222 mi.
    Est. $636/mo

    Autos of Dallas

    3.2
    Check Availability
    Plano, TX (16 mi)
    Quick view
  • Black 2021 Lexus IS 350 F-SportBlack 2021 Lexus IS 350 F-SportBlack 2021 Lexus IS 350 F-SportBlack 2021 Lexus IS 350 F-SportBlack 2021 Lexus IS 350 F-SportBlack 2021 Lexus IS 350 F-Sport

    $40,998

    51,042 mi.
    Est. $757/mo

    CarMax Amarillo

    4.6
    Check Availability
    $149 delivery to Irving, TX (9 mi)
    Quick view
  • White 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-SportWhite 2021 Lexus IS 350 F-Sport

    $32,998

    90,102 mi.
    Est. $609/mo

    CarMax Des Moines

    4.0
    Check Availability
    $499 delivery to Irving, TX (9 mi)
    Quick view
  • Gray 2021 Lexus IS 350 F-SportGray 2021 Lexus IS 350 F-SportGray 2021 Lexus IS 350 F-SportGray 2021 Lexus IS 350 F-SportGray 2021 Lexus IS 350 F-SportGray 2021 Lexus IS 350 F-Sport

    $38,998

    32,647 mi.
    Est. $720/mo

    CarMax Hulen Mall

    Check Availability
    Fort Worth, TX (38 mi)
    Quick view
  • Grecian Water 2021 Lexus IS 350 BaseGrecian Water 2021 Lexus IS 350 BaseGrecian Water 2021 Lexus IS 350 BaseGrecian Water 2021 Lexus IS 350 Base

    $44,680

    33,835 mi.
    Est. $825/mo

    Tom Clark Chevrolet

    Check Availability
    Denton, TX (38 mi)
    Quick view
  • $39,912

    37,125 mi.
    Est. $737/mo

    Autobahn BMW Fort Worth

    4.3
    Check Availability
    Fort Worth, TX (35 mi)
    Quick view

Lexus IS 350 prices by year

Model year Average price Deals
2026 Lexus IS 350 $56,012 1 Good deal
2025 Lexus IS 350 $48,682 9 Good deals
2024 Lexus IS 350 $45,243 7 Great deals
2023 Lexus IS 350 $45,598 8 Great deals
2022 Lexus IS 350 $41,469 5 Great deals

About the 2021 Lexus IS 350

Basics

F Sport shown (base trim).

Seating
5
Door count
4
Drivetrain
Rear-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
311.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2021 Lexus IS 350
FAQs

How much does the 2021 Lexus IS 350 cost?

The 2021 Lexus IS 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2021 IS 350 is $37,776, with pricing starting at $29,950.

What is the MPG of the 2021 Lexus IS 350?

The 2021 Lexus IS 350 offers up to 20 MPG in city driving and 28 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2021 Lexus IS 350 reliable?

The 2021 Lexus IS 350 has an average reliability rating of 5 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2021 IS 350 owners.

Is the 2021 Lexus IS 350 a good sedan?

Below are the Cars.com consumer ratings for the 2021 Lexus IS 350.

(2 reviews)
Rating breakdown (out of 5):
Comfort
5.0
Interior
4.5
Performance
5.0
Value
4.5
Exterior
5.0
Reliability
5.0
Ratings (2 reviews)

100% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
5.0
Interior
4.5
Performance
5.0
Value
4.5
Exterior
5.0
Reliability
5.0
Trims

IS 350 F SPORT (2 styles)

Style
IS 350 F SPORT RWD IS 350 F SPORT AWD
Inventory price
Starting at $42,950 Starting at $44,950
Combined MPG
23 22
Engine
311.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 311.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Skip to Listings
Best match Lowest price Highest price Lowest mileage Highest mileage Nearest location Best deal Newest year Oldest year Newest listed Oldest listed