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  • Atomic Silver 2022 Lexus RX 350 F SPORT Appearance

    $47,784

    14,776 mi.
    Est. $898/mo

    Berman Subaru of Chicago

    4.9
    Check Availability
    Chicago, IL (9 mi)

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  • Atomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT HandlingAtomic Silver 2022 Lexus RX 350 F SPORT Handling

    $43,367

    $998
    71,461 mi.
    Est. $815/mo

    McGrath Lexus Chicago

    4.8
    Check Availability
    Chicago, IL (4 mi)

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  • Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350Blue 2022 Lexus RX 350

    $48,998

    14,879 mi.
    Est. $921/mo

    CarMax Schaumburg

    4.5
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    Schaumburg, IL (25 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $41,373

    44,729 mi.
    Est. $778/mo

    Audi Westmont

    4.8
    Check Availability
    Westmont, IL (16 mi)
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  • Atomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 BaseAtomic Silver 2022 Lexus RX 350 Base

    $46,495

    $400
    42,866 mi.
    Est. $874/mo

    Lexus of Arlington

    4.7
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    Palatine, IL (29 mi)
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  • Eminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 BaseEminent White Pearl 2022 Lexus RX 350 Base

    $55,408

    23,409 mi.
    Est. $1,041/mo

    Woodfield Lexus

    4.8
    Check Availability
    Schaumburg, IL (25 mi)
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  • $45,365

    64,708 mi.
    Est. $853/mo

    McGrath Lexus Chicago

    4.8
    Check Availability
    Chicago, IL (4 mi)
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  • $46,365

    40,616 mi.
    Est. $871/mo

    McGrath Lexus of Westmont

    4.9
    Check Availability
    Westmont, IL (16 mi)
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  • $48,365

    48,254 mi.
    Est. $909/mo

    McGrath Lexus of Westmont

    4.9
    Check Availability
    Westmont, IL (16 mi)
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  • $44,900

    24,483 mi.
    Est. $844/mo

    Haus of Imports

    4.3
    Check Availability
    Lemont, IL (17 mi)
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  • Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350Black 2022 Lexus RX 350

    $37,998

    48,610 mi.
    Est. $714/mo

    CarMax Augusta

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    $499 delivery to Oak Lawn, IL (11 mi)
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  • Black 2022 Lexus RX 350 LBlack 2022 Lexus RX 350 LBlack 2022 Lexus RX 350 LBlack 2022 Lexus RX 350 LBlack 2022 Lexus RX 350 LBlack 2022 Lexus RX 350 L

    $42,998

    34,349 mi.
    Est. $808/mo

    CarMax Town Center

    Check Availability
    $599 delivery to Oak Lawn, IL (11 mi)
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  • Nebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 BaseNebula Gray Pearl 2022 Lexus RX 350 Base

    $37,988

    $964
    45,499 mi.
    Est. $714/mo

    Rod Baker Ford

    4.6
    Check Availability
    Plainfield, IL (32 mi)
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  • Caviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 BaseCaviar 2022 Lexus RX 350 Base

    $42,490

    46,330 mi.
    Est. $799/mo

    Lexus of Merrillville

    Check Availability
    Merrillville, IN (30 mi)
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  • $46,490

    29,152 mi.
    Est. $874/mo

    Lexus of Merrillville

    Check Availability
    Merrillville, IN (30 mi)
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Lexus RX 350 prices by year

Model year Average price Deals
2026 Lexus RX 350 $63,747 1 Good deal
2025 Lexus RX 350 $59,408 8 Good deals
2024 Lexus RX 350 $53,715 29 Good deals
2023 Lexus RX 350 $49,543 7 Great deals
2021 Lexus RX 350 $40,076 8 Good deals
2020 Lexus RX 350 $34,218 7 Good deals
2017 Lexus RX 350 $26,236 8 Great deals

About the 2022 Lexus RX 350

Basics

Base shown (base trim).

Seating
5
Door count
4
Drivetrain
Front-wheel drive
Combined MPG
23
Transmission
8-Speed A/T
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Lexus RX 350
FAQs

How much does the 2022 Lexus RX 350 cost?

The 2022 Lexus RX 350 price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 RX 350 is $41,101, with pricing starting at $27,790.

What is the MPG of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 offers up to 20 MPG in city driving and 27 MPG on the highway for a combined rating of 23 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

What are some similar vehicles and competitors of the 2022 Lexus RX 350?

The 2022 Lexus RX 350 compares to and/or competes against the following vehicles:


Is the 2022 Lexus RX 350 reliable?

The 2022 Lexus RX 350 has an average reliability rating of 3.9 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 RX 350 owners.

Is the 2022 Lexus RX 350 a good SUV?

Below are the Cars.com consumer ratings for the 2022 Lexus RX 350.

(13 reviews)
Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Ratings (13 reviews)

61% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
4.6
Interior
4.5
Performance
3.8
Value
3.5
Exterior
4.7
Reliability
3.9
Trims

RX 350 (2 styles)

Style
RX 350 FWD RX 350 AWD
Inventory price
Starting at $45,920 Starting at $47,320
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Appearance (2 styles)

Style
RX 350 F SPORT Appearance FWD RX 350 F SPORT Appearance AWD
Inventory price
Starting at $49,400 Starting at $50,800
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)

RX 350 F SPORT Handling (2 styles)

Style
RX 350 F SPORT Handling FWD RX 350 F SPORT Handling AWD
Inventory price
Starting at $51,800 Starting at $53,200
Combined MPG
23 22
Engine
295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel) 295.0-hp, 3.5-liter, V6 Cylinder Engine (Gasoline Fuel)
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