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  • Polar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainPolar White 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $46,962

    $192
    45,875 mi.
    Est. $883/mo

    Mercedes-Benz of Foothill Ranch

    4.8
    Check Availability
    Lake Forest, CA (1,725 mi)

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  • Black 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATIC

    $45,497

    61,459 mi.
    Est. $855/mo

    Umansky Toyota

    4.7
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    Milwaukee, WI (87 mi)
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  • Blue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATICBlue 2022 Mercedes-Benz E-Class E 450 4MATIC

    $49,500

    $2.5K
    45,841 mi.
    Est. $930/mo

    Jessup Auto Plaza

    4.6
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    Cathedral City, CA (1,661 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $50,000

    36,734 mi.
    Est. $940/mo

    Mike Ward INFINITI

    4.6
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    Highlands Ranch, CO (923 mi)
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  • Nautical Blue 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainNautical Blue 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $43,490

    $500
    48,695 mi.
    Est. $817/mo

    Unique Auto Mall

    4.7
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    South Amboy, NJ (701 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATICBlack 2022 Mercedes-Benz E-Class E 450 4MATIC

    $50,366

    25,111 mi.
    Est. $947/mo

    Kunes Honda of Sycamore

    4.3
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    Sycamore, IL (56 mi)
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  • White 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainWhite 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $50,452

    $447
    24,270 mi.
    Est. $948/mo

    BMW of Ramsey

    4.3
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    Ramsey, NJ (701 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $51,900

    37,200 mi.
    Est. $976/mo

    Mercedes-Benz Manhattan Inc.

    4.6
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    New York, NY (712 mi)
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  • Black 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainBlack 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $48,750

    43,049 mi.
    Est. $916/mo

    Grand Motorcars Kennesaw

    1.5
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    Kennesaw, GA (569 mi)
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  • Graphite Grey Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainGraphite Grey Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $54,998

    39,289 mi.
    Est. $1,034/mo

    Mercedes-Benz of Fresno

    3.0
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    Fresno, CA (1,743 mi)
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  • MANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class E 450 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class E 450 4MATICMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC

    $50,882

    27,498 mi.
    Est. $956/mo

    Mercedes-Benz Of Daytona Beach

    4.8
    Daytona Beach, FL (950 mi)
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  • Black 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-ClassBlack 2022 Mercedes-Benz E-Class

    $52,998

    21,238 mi.
    Est. $996/mo

    CarMax Ft. Myers

    3.6
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    Fort Myers, FL (1,106 mi)
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  • Obsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainObsidian Black Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $45,750

    9,997 mi.
    Est. $860/mo

    Drive A Dream

    3.8
    Check Availability
    Marietta, GA (572 mi)
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  • MANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-TerrainMANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $49,000

    22,460 mi.
    Est. $921/mo

    Drive A Dream

    3.8
    Check Availability
    Marietta, GA (572 mi)
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  • Gray 2022 Mercedes-Benz E-Class E 450 4MATICGray 2022 Mercedes-Benz E-Class E 450 4MATICGray 2022 Mercedes-Benz E-Class E 450 4MATICGray 2022 Mercedes-Benz E-Class E 450 4MATICGray 2022 Mercedes-Benz E-Class E 450 4MATICGray 2022 Mercedes-Benz E-Class E 450 4MATIC

    $43,981

    48,261 mi.
    Est. $827/mo

    Calstar Motors Inc

    4.9
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    Glendale, CA (1,740 mi)
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  • Polar White 2022 Mercedes-Benz E-Class

    $51,015

    38,992 mi.
    Est. $959/mo

    Mercedes-Benz of St Louis

    4.3
    St. Louis, MO (265 mi)
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  • Diamond 2022 Mercedes-Benz E-Class E 450 4MATIC All-Terrain

    $54,900

    23,842 mi.
    Est. $1,032/mo

    Mercedes-Benz Manhattan Inc.

    4.6
    Check Availability
    New York, NY (712 mi)
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Mercedes-Benz E-Class prices by year

Model year Average price Deals
2026 Mercedes-Benz E-Class $87,107 7 Good deals
2025 Mercedes-Benz E-Class $74,782 8 Great deals
2023 Mercedes-Benz E-Class $71,115 7 Great deals

About the 2022 Mercedes-Benz E-Class

Basics

E 350 shown (base trim).

Seating
5
Door count
4
Drivetrain
Rear-wheel drive
Combined MPG
26
Transmission
9-Speed A/T
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)
Side view of the 2022 Mercedes-Benz E-Class
FAQs

How much does the 2022 Mercedes-Benz E-Class cost?

The 2022 Mercedes-Benz E-Class price depends on several factors, including the trim level, optional features, mileage, vehicle history and location. The nationwide average price for a 2022 E-Class is $38,792, with pricing starting at $25,972.

What is the MPG of the 2022 Mercedes-Benz E-Class?

The 2022 Mercedes-Benz E-Class offers up to 23 MPG in city driving and 31 MPG on the highway for a combined rating of 26 MPG.

These figures are based on EPA mileage ratings and are for comparison purposes only. The actual mileage will vary depending on the selected vehicle trim, driving conditions, driving habits, vehicle maintenance, and other factors.

Is the 2022 Mercedes-Benz E-Class reliable?

The 2022 Mercedes-Benz E-Class has an average reliability rating of 3.3 out of 5 according to Cars.com consumers. Find real-world reliability insights within consumer reviews from 2022 E-Class owners.

Is the 2022 Mercedes-Benz E-Class a good sedan?

Below are the Cars.com consumer ratings for the 2022 Mercedes-Benz E-Class.

(3 reviews)
Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Ratings (3 reviews)

66% of drivers recommend this car

Rating breakdown (out of 5):
Comfort
3.7
Interior
3.3
Performance
4.3
Value
4.0
Exterior
4.0
Reliability
3.3
Trims

E 350 (2 styles)

Style
E 350 4MATIC Sedan E 350 RWD Sedan
Inventory price
Starting at $57,450 Starting at $54,950
Combined MPG
24 26
Engine
255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel) 255.0-hp, 2.0-liter, 4 Cylinder Engine (Gasoline Fuel)

E 450 (6 styles)

Style
E 450 4MATIC All-Terrain Wagon E 450 4MATIC Coupe E 450 RWD Coupe E 450 4MATIC Sedan E 450 RWD Cabriolet E 450 4MATIC Cabriolet
Inventory price
Starting at $68,400 Starting at $68,600 Starting at $66,100 Starting at $62,750 Starting at $73,250 Starting at $75,750
Combined MPG
24 24 25 25 25 24
Engine
362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid) 362.0-hp, 3.0-liter, Straight 6 Cylinder Engine (Gasoline/Mild Electric Hybrid)
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